Last week British scientists announced that they had created sperm cells
from embryonic stem cells for the first time.
In addition, we use our expertise to facilitate the development of functionally mature beta cells
from embryonic stem cells for cell replacement therapies of type 1 diabetes.
Not exact matches
Scientists looking
for new methods to make human tissue have successfully used cloning technology to create
embryonic stem cells from skin
cells.
The National Institutes of Health (NIH) has allowed a contract
for the dissemination of
embryonic stem cell lines approved
for US government funding to lapse, shuttering a key
stem cell bank, and doubling the price researchers pay
for samples of some human
embryonic stem cell (hESC) line...
from $ 500 per vial of frozen
cells to $ 1,000.
In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity
for embryonic stem -
cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent
stem cells» («iPS», i.e.
stem cells reprogrammed
from some
cells of a living adult).
(In many ways it is worse than when John Edwards said in 2004 that if people voted
for John Kerry, people like Christopher Reeve would get out of their wheelchairs and walk
from embryonic stem cell therapies.)
For example, ten or twenty years from now, the physician's tools may include embryonic stem cells or products obtained from cloned embryos and fetuses gestated for that purpose, making physicians who provide such treatments complicit in the life destruction required to obtain the modaliti
For example, ten or twenty years
from now, the physician's tools may include
embryonic stem cells or products obtained
from cloned embryos and fetuses gestated
for that purpose, making physicians who provide such treatments complicit in the life destruction required to obtain the modaliti
for that purpose, making physicians who provide such treatments complicit in the life destruction required to obtain the modalities.
The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA»)
for short, in human
embryonic kidney
cells, brain
cell samples and neurons derived
from the
stem cells of healthy people and those with spinal muscular atrophy type I and II.
Faced with an often - hostile Congress, Obama enacted many of his signature policies by executive order —
from reversing restrictions on research with human
embryonic stem cells to helping communities prepare
for climate change.
For example, a consortium of research groups called the London Project to Cure Blindness aims to test RPE transplants
from embryonic stem cells in patients with macular degeneration this year.
Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method
for generating neurons
from human
embryonic stem cells rejected by the court, called the ruling «the worst possible outcome», and «a disaster
for Europe».
Advanced
Cell Technology, based in Santa Monica California, is developing embryonic stem cell therapies for macular degeneration and other conditions using cells obtained non-destructively from an early embryo called a blastoc
Cell Technology, based in Santa Monica California, is developing
embryonic stem cell therapies for macular degeneration and other conditions using cells obtained non-destructively from an early embryo called a blastoc
cell therapies
for macular degeneration and other conditions using
cells obtained non-destructively
from an early embryo called a blastocyst.
Researchers at Geron, meanwhile, had successfully derived neurons
from human
embryonic stem cells and were pursuing research that would eventually look to repair the damage caused by spinal - cord injuries, a possible use
for embryonic stem cells that was much touted at the time.
«We've figured out
for the first time how to produce these
cells from human
embryonic stem cells literally by the billions and billions,» Lanza says.
For example, animal studies have shown that neurons derived in the lab
from human
embryonic stem cells improve Parkinson's symptoms; however, any residual
stem cells associated with those neurons could form masses of unwanted
cells.
In addition, where
cells derived
from embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient numbers of
cells for clinical use — ones
from the iPS lines were much feebler.
Although British researchers had discovered
embryonic stem cells in laboratory animals in 1981, it wasn't until 1998 that a Wisconsin team announced it had isolated
stem cells from human embryos
for the first time.
The patch is made of eye
cells made
from human
embryonic stem cells, and it has been designed
for treating the «dry» form of macular degeneration, which accounts
for 90 per cent of all cases, and affects 1.7 million people in the US.
► On Wednesday at ScienceInsider, Tania Rabesandratana reported
from Brussels that the European Commission has denied a request by a citizens» initiative to «block E.U. funding
for research using
embryonic stem cells.»
«We can work with any
embryonic stem cell line
from any source and are not restricted to working with the very small number of federally approved lines as is the case
for researchers in the United States,» says Minger.
Researchers already envision transplanting ready - made
embryonic stem cells back into people, providing cures
for a huge range of diseases,
from diabetes to paralysis to Alzheimer's.
Plus, hopes
for therapeutic cloning rest on the ability to produce
embryonic stem cells from cells harvested
from diseased patients.
Further investigation, says Resar, showed that these unusual properties arise
from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary
for embryonic development and
stem cell activity.
Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center
for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using
embryonic stem cells, first
from mice and then humans.
For the purpose of additional experiments, the researchers generated myocardial
cells from embryonic stem cells and human skin
cells, in collaboration with the lab headed by Prof Dr Jürgen Hescheler at the University of Cologne.
At the University of Washington, Hannele Ruohola - Baker, professor of biochemistry and associate director of the Institute
for Stem Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw embryonic stem cell lines from liquid nitrogen stor
Stem Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw embryonic stem cell lines from liquid nitrogen stor
Cell and Regenerative Medicine, Julie Mathieu, acting instructor and Henrik Sperber, graduate student, withdraw
embryonic stem cell lines from liquid nitrogen stor
stem cell lines from liquid nitrogen stor
cell lines
from liquid nitrogen storage.
(This report, which Harvard biologist Eggan calls the «Human
Embryonic Stem Cell Misinformation Packet,» prompted a corrective letter
from Harvard biologists, who claimed that the White House misrepresented their research
for political reasons.)
«Giant leap
for diabetes:
From human
embryonic stem cells to billions of human insulin producing
cells.»
«Use of induced pluripotent
stem cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into
embryonic - like
stem cells capable of turning into other specific
cell types relevant
for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.
In 2004 Blackburn and ethicist William F. May made headlines when the Bush administration ousted them
from the President's Council on Bioethics
for their strong public support of human
embryonic stem cell research.
These
stem cells, which are similar to highly sought - after
embryonic stem cells but derived
from adult
cells and then reprogrammed, could be turned into the
cell types needed
for research, including neurons and intestinal and fat
cells.
The result — the second such finding in the past year — suggests that similar
cells from human testicles might have similar powers, paving the way to creating replacement tissue
for men who have suffered damage
from heart attacks or other injuries and avoiding some of the controversy surrounding
embryonic stem cells (ESC).
Last December,
for instance, Chien's group reported finding markers
for heart muscle
stem cells by tracing their development
from embryonic tissue.
The new approach builds on information gleaned
from developmental studies of
embryonic stem cells (see story # 16) and one day may be used to create healthy replacements
for harmed or diseased tissue.
Renee Reijo Pera, a biologist at Stanford's Institute
for Stem Cell Biology and Regenerative Medicine, points out that earlier attempts to create offspring with sperm from embryonic stem cells resulted in short - lived mouse pups that were either giants or midg
Stem Cell Biology and Regenerative Medicine, points out that earlier attempts to create offspring with sperm
from embryonic stem cells resulted in short - lived mouse pups that were either giants or midg
stem cells resulted in short - lived mouse pups that were either giants or midgets.
Scientists
from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene
for embryonic stem cells, also regulates
cell division in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina — in adult organisms.
Scientists have already reported progress in growing precursor
cells for eggs and sperm
from both iPS and
embryonic stem cell lines.
Niakan and colleagues predicted
from earlier work with mice and human
embryonic stem cells that the protein OCT4 would be necessary
for the epiblast
cells to develop correctly.
One is using
cells derived
from human
embryonic stem cells to treat spinal cord injury (although funding problems have stopped the trial enrolling new patients) and another is testing a treatment
for age - related macular degeneration.
Best known
for his Superman films, Reeve had long advocated research into
embryonic stem cells to repair the kind of spinal cord injury that left him paralyzed
from the neck down after a horseback riding accident 10 years ago.
Scientists have created red blood
cells from human
embryonic stem cells, in a step that they say could mean an infinite source of blood
for transfusions.
Next, the team used both human
embryonic NPCs and human NPCs generated
from stem cells to tweak the protocol
for human use.
Still, the genetic homogeneity of largely inbred mouse strains may be misleading when it comes to understanding human
stem cells, cautions Peter Andrews, professor of biomedical science and co-director of the Centre for Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andr
stem cells, cautions Peter Andrews, professor of biomedical science and co-director of the Centre
for Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andr
Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andr
Cell Biology at the University of Sheffield, U.K. «In the human, every
embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andr
stem cell that we're working with that comes from a different person is genetically different,» says Andr
cell that we're working with that comes
from a different person is genetically different,» says Andrews.
There is promising news today
for those who hope to turn the potential of undifferentiated
stem cells into medical miracles: Researchers are reporting a way to produce insulin - producing
cells from mouse
embryonic stem cells.
Since its inception, CIRM has sought to create a system
from the ground up
for funding research on human
embryonic stem cells to fill in the gaps left by federal funding restrictions (ScienceNOW, 12 April).
Expanding
from their previous studies with mice, the researchers first established that under specific conditions, culturing human
embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers
for the cerebellar plate neuroepithelium — the part of the developing nervous system specific
for the cerebellum — within five.
His recent published work describes the rescued visual function in animals using retinal pigment epithelial
cells derived
from human
embryonic stem cells and a method
for deriving
stem cells using a single -
cell approach that does not harm embryos.
For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrop
For the first time, through the use of human
embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
stem cells (hES) sourced
from pre-implantation diagnosis, researchers
from Inserm's Institute
for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrop
for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
Stem Cell Therapy and Exploration of Monogenic Diseases (I -
Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystro
Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.
NeuroStemcell is focused on the identification and systematic comparison of progenitor
cell lines with the most favourable characteristics
for mesDA and striatal GABAergic neuronal differentiation, generated either directly
from human
embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells,
from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived
from ES
cells or fetal brain,
from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or
from in vitro short - term expanded neural progenitors
from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.
February 2010 - Italian
stem cell scientists challenge goverment EuroSyStem scientist Elena Cattaneo challenges Italian government - the story continues In the summer of 2009, three Italian
stem celli scientists unsuccessfully challenged their government in the courts over its decision to exclude human
embryonic stem cell research
from a ministerial funding call
for projects on
stem cell biology.