Blastoma: Tumors formed
from embryonic tissue or developing cells are known as blastomas and are more common in children than adults.
Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development
from embryonic tissue.
Not exact matches
Scientists looking for new methods to make human
tissue have successfully used cloning technology to create
embryonic stem cells
from skin cells.
From the
embryonic stem cells, the researchers produced a type of
tissue called retinal pigment epithelium (RPE).
Da Cruz and his team grew replacement RPE cells
from human
embryonic stem cells on a thin plastic scaffold, before transplanting the
tissue into the back of each volunteer's eye.
Two people with severe sight loss can now see well enough to read after receiving
tissue grown
from human
embryonic stem cells.
Stem cells
from breast milk can grow into many other kinds of human
tissue, raising hopes of an ethical source of
embryonic - like stem cells
ERRORS have occurred in a type of stem cell that could be used instead of
embryonic stem cells — and in
tissues made
from them.
Like a Texan who keeps his drawl after moving to California, adult cells reprogrammed to resemble
embryonic cells retain some signatures of the
tissue from which they came.
On the other hand, the problem is, you know, with
embryonic stem cells, they haven't been able to get stem cell lines
from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain
tissue or bone
tissue or something else.
Organlike
tissue bits can be generated
from pluripotent stem cells that are either plucked
from embryos or created by taking a person's adult skin or blood cells and chemically inducing them to revert to an
embryonic - like state.
The results help fill in the scientific puzzle kicked off by Dolly's cloning, which proved that mammalian egg cells were capable of dissolving the genetic roadblocks that limit the potential of most adult cells to give rise to only a single type of
tissue — that of the organ
from which they hail — whereas
embryonic stem cells have the potential to become virtually any kind of body
tissue.
Stem cells
from adult bone marrow normally generate bone, muscle, cartilage and fat cellsa limited set compared with
embryonic stem cells, which can spawn the full spectrum of adult
tissues.
The result — the second such finding in the past year — suggests that similar cells
from human testicles might have similar powers, paving the way to creating replacement
tissue for men who have suffered damage
from heart attacks or other injuries and avoiding some of the controversy surrounding
embryonic stem cells (ESC).
The new approach builds on information gleaned
from developmental studies of
embryonic stem cells (see story # 16) and one day may be used to create healthy replacements for harmed or diseased
tissue.
Pluripotent stem cells include
embryonic stem cells, which are derived
from early embryos, and induced pluripotent stem cells, which are made by reprogramming cells taken
from adult
tissues such as skin.
A team of researchers
from DuPont added so - called morphogenic genes — known
from basic research to promote the production of
embryonic tissue — to the other genes being transformed (in this case to express green fluorescent protein as a marker of transformation).
From an entire organ to a dose of embryonic stem cells, if the tissue's DNA came from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive dr
From an entire organ to a dose of
embryonic stem cells, if the
tissue's DNA came
from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive dr
from anyone else, the transplant would be rejected without the aid of harsh immunosuppressive drugs.
Moreover, if
embryonic stem cells were cloned
from the patient, he or she wouldn't have problems with immunological rejection of the cultured
tissue.
Specifically, the researchers generated the
tissue from human
embryonic stem cells with the resulting muscle having significant similarities to human heart muscle.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived
from embryonic stem cells and
from human fetal brain
tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.
This has always been a worry with
tissues produced
from embryonic stem cells, as these have the capability to form tumours if any are left in their original state in the transplanted
tissue.
Vermulst's study looked only at
tissues from the heart, brain, and
embryonic fibroblasts.
A group that included researchers at the Wellcome Trust Sanger Institute and the University of Cambridge, both in the United Kingdom, developed a possible treatment for A1ATD by first reprogramming a skin cell
from a patient into iPS cells, which are
embryonic - like cells that can develop into many
tissue types.
The researchers did this by injecting the cells into
embryonic pancreatic
tissue taken
from mice engineered to lack neurogenin 3.
The research used skin samples
from five men to create what are known as induced pluripotent stem cells, which closely resemble
embryonic stem cells in their ability to become nearly any
tissue in the body.
According to the researchers, these findings suggest that differences in shape
from cell - to - cell within a
tissue are key to their ability to jam and unjam — and that this process appears to drive biological events including
embryonic development, wound healing, and, potentially, cancer cell invasion.
The potential of iPS cells to help treat everything
from damaged heart
tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast cells as an alternative to controversial
embryonic stem cells.
Tumors were suspected to be
tissues that had been triggered to become
embryonic - like again, and it is now generally accepted that tumors are indeed more «
embryonic» than the
tissues they are derived
from, due to the re-expression of
embryonic - related genes.
This finding complements previous research
from the University of Edinburgh and the National Institute for Medical Research which showed that
embryonic stem cells can be coaxed into this spinal cord cells; however, the Cambridge researchers showed that the in the embryo - like aggregates, the structural organization is more robust and allows for the polarised growth of the
tissue.
iPSCs are cells that can be take
from adult
tissue and «reprogrammed» into
embryonic stem cell (ESC)- like cells.
A research team said it has produced stratified retinal
tissues from human
embryonic stem cells for the first time in...
2007 also saw one of the most game - changing developments in the stem cell field; researchers learned how to create cells like
embryonic stem cells, but instead of coming
from an embryo these cells are created
from adult cells, potentially cells
from any
tissue in the human body.
The idea of reprogramming a cell
from adult
tissue into an
embryonic - like cell existed long before the creation of iPS cells.
The relationship between cancer and
embryonic tissues was first proposed in the 1870s by Francesco Durante and Julius Cohnheim, who thought that cancers originated
from cells in adults that persist in an immature,
embryonic - like state.
A human
embryonic stem cell is reined in — prevented
from giving up its unique characteristics of self - renewal and pluripotency — by the presence of a protein modification that stifles any genes that would prematurely instruct the cell to develop into heart or other specialized
tissue.
iPSCs are cells that were originally
from adult
tissues, but have been forced to produce proteins that are thought to be essential for the pluripotency of human
embryonic stem cells.
The idea of reprogramming a cell
from adult
tissue into an
embryonic - like, pluripotent cell existed long before the creation of iPSCs.
Stem cells harvested
from amniotic fluid and placental
tissue are readily obtainable and have properties of both
embryonic and adult stem cells.
Because the cells were derived
from human embryos or fetal
tissue, pro-life groups condemned
embryonic stem cell research as morally wrong.
Mouse brain
tissue from three different stages of the mouse brain development;
embryonic day 15, postnatal day 2 and postnatal day 21, was studied.
Most Alkbh1 deficient mice die during
embryonic development, and survivors are characterized by defects in
tissues originating
from the ectodermal lineage.
InvivoSciences makes engineered heart
tissues from mouse
embryonic stem cells and stem cells
from differentiated adult
tissues in humans, such as fat and skin.
Prof Muzlifah Haniffa,
from Newcastle University, said: «This research is possible due to the Human Developmental Biology Resource, which provides human
embryonic and fetal
tissues to ethically approved scientific studies such as the HDCA.
Both human
embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) can colonize the mouse embryo in a manner predicted
from classical developmental fate mapping and faithfully recapitulate
tissue - specific fate post-transplantation.
Adult stem cells were once believed to be more limited than
embryonic stem cells, only giving rise to the same type of
tissue from which they originated.
Teratomas containing derivatives
from all three
embryonic germ layers confirmed that the hiPSCs (but not the original NPCs used) were pluripotent and able to differentiate to complex
tissues in two different experimental settings (Fig. 2J and Figure S3).
Embryonic stem cells derived
from human blastocysts have the key advantage of pluripotency, meaning that they form nearly all cell types but also have the disadvantage of forming tumors in vivo, which may limit clinical application to
tissue engineering rather than cell transplantation.
But in investigator - blinded comparisons of
tissue sections
from each group of mice, no evidence of defects related to loss of Wnt signaling were found in
embryonic or adult pulmonary, renal, cerebral, or skeletal
tissues.
Mouse
embryonic stem cells derived
from the epiblast contribute to the somatic lineages and the germline but are excluded
from the extra-
embryonic tissues that are derived
from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.