Sentences with phrase «from endothelial»

Until recently, it was generally accepted that the tumors arise from endothelial (blood vessel lining) cells.

Well, it's also been shown to protect the arteries from endothelial dysfunction in animal studies.

Women suffering from endothelial dysfunction exhibit poor circulation due to problems with vascular distance regulation.

Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).

Impaired release of nitric oxide from endothelial cells is associated with cardiovascular disease.

The vasculature can influence neural stem cell proliferation and differentiation by providing a local source of signaling molecules secreted from endothelial cells (1) as well as by delivering systemic regulatory factors (2).

The Tie - 2 ligand angiopoietin - 2 is stored in and rapidly released upon stimulation from endothelial cell Weibel - Palade bodies.

In the current study, the researchers showed that FGPs are present on the surface of the zebrafish brain and that these blood vessel - associated FGPs do not arise from the immune system, as had been previously thought, but from endothelial cells themselves.

Because they turned green, it was apparent that they arose from endothelial cells.

When zebrafish with the green fluorescing endothelial gene matured, the researchers observed green FGPs on the surface of the fish's brains — confirming that these cells arose from endothelial tissue.

In another test, the researchers looked to see if chemical signals released from the endothelial cells would cause the media layer to relax and constrict, as they do in the human body.

These particles come from endothelial cells, platelets, and monocytes and indicate that cells in the blood vessels are being damaged.

Not exact matches

Another approach might be to selectively remove CD11b leukocytes from the blood circulation so that they are not available to adhere to the blood - nerve barrier endothelial cells in patient's nerves.

Sydenham chorea was like rheumatic fever of the brain, thought to occur when rheumatic fever progresses and strep antibodies (emboldened by fever) breaches the blood - brain barrier (BBB), the tight wall of endothelial cells ordinarily there to protect the brain from the outside world.

Among dozens of mouse studies, he presented work led by Moderna Co-Founder Kenneth Chien, then at Harvard Medical School in Boston, showing that mice recovering from induced heart attacks survived longer and had stronger hearts when injected with mRNA encoding a protein that drives blood vessel formation — vascular endothelial growth factor (VEGF).

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

Rather, parasites move directly from the blood into endothelial cells, where they replicate, cause the cell to burst and then infect neighboring brain cells.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

«Endothelial cells play a very important role in multiple steps of many diseases, from initiation to the onset of clinical complications,» says Aikawa, who was not part of the research team.

Researchers from the UNC School of Medicine have discovered that cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into endothelial cells, which generate blood vessels to supply oxygen and nutrients to the injured regions of the heart, thus greatly reducing the damage done following heart attack.

Within the blood vessels of the brain, endothelial cells and other adjacent cells form a tight barrier that helps to prevent toxins and microbes from entering the brain.

The researchers found that the endothelial cells generated from fibroblasts actually gave rise to functioning blood vessels.

Professor Takao Hamakubo's group at the Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), have shown that PTX3 forms strong bonds with histones and partially unfolds, leading to a disordered coaggregation of histone and PTX3 and protecting human endothelial cells from damage.

The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and the same type of cells from the lung, heart and bone marrow for the in vivo component.

The virus attacks the host's endothelial cells and platelet cells, damaging both and preventing the latter from coagulating.

Additionally, the newly described proliferating cells hold the promise of being able to regenerate a person's own endothelial cells, even in cases of FECD, as an alternative to transplanting corneas from a donor.

Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as «neural crest - derived progenitor cells») in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs» Endothelial Corneal Dystrophy (FECD), a condition in which the cells responsible for keeping the cornea clear die prematurely — often leading to blindness.

This is clear from the fact that the third drug in the study, sodium nitroprusside, does not affect endothelial cells, but still produced different effects in the veins of black people and white people.

An impermeable shield of endothelial cells that protects our brains from toxins and other threats that may lurk in circulating blood, the barrier can also exclude therapeutic drugs and, at times, essential biomolecules required for healthy brain development.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

Cells from the penises with stem cell - laced grafts contained more neuronal and endothelial NOS, enzymes that help trigger and maintain erections.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

In human endothelial cell monolayers in culture, NS1 from any of the four DENV serotypes triggered endothelial barrier permeability.

We also demonstrate that NS1 from DENV1, DENV2, DENV3, and DENV4 triggers endothelial barrier dysfunction, causing increased permeability of human endothelial cell monolayers in vitro.

The anti-vascular endothelial growth factor drugs ranibizumab and aflibercept, used to treat vision loss from diabetic macular edema (DME), and approximately 20 to 30 times more expensive than bevacizumab, are not cost - effective for treatment of DME compared to bevacizumab unless their prices decrease substantially, according to a study published online by JAMA Ophthalmology.

This experiment uses quantitative PCR to detect the expression level of POSTN in CD34 + / CD31 − pulmonary fibroblasts, CD31 + endothelial cells, and CD45 + immune cells isolated from lungs of mice with macrometastases, which is a replication of the experiment reported in Figure 2H.

To overcome these limitations, we used two - color flow cytometry to identify and select microvascular endothelial cells from primary cultures obtained from different organs of mice whose tissues harbor a temperature - sensitive SV40 large T antigen (H - 2Kb - tsA58 mice; ImmortoMice).

Cultured endothelial cells from lung, colon, kidney, bladder, liver, and ovary displayed a cobblestone appearance after reaching confluence.

B, CSCs isolated from 231BrM infected with lentivirus of miR7 or KLF4 expression plasmids were seeded on top of mouse brain endothelial cells or Matrigel.

Endothelial cells (passage 5) from each line were plated onto 96 - well plates at a density of 1000 cells / well in 10 % DMEM.

One of the major impediments to obtaining a large number of endothelial cells from different tissues has been the inability to purify and propagate these cells in culture.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

Tissue - specific microvascular endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis

The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.

Each of the endothelial cell lines established from the H - 2Kb - tsA58 transgenic mice was capable of generating vascular - like channels on Matrigel within 12 h.

At that key point, Takebe added two more types of cell known to help to recreate organ - like function in animals: endothelial cells, which line blood vessels, taken from an umbilical cord; and mesenchymal cells, which can differentiate into bone, cartilage or fat, taken from bone marrow.

When primary cultures from these mice are stimulated with proinflammatory cytokines, the endothelial cell fraction responds by up - regulating the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.