Sentences with phrase «from epigenetic modification»

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Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

The chemical modification of histones is thought to be a form of epigenetic information — information separate from our DNA — that controls gene regulation.

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples» reproductive success via epigenetic modifications of sperm DNA.

So, we're very interested in seeing whether some of these epigenetic modifications can go from one generation to the next, but that remains much more controversial.

He and his team at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany used fruit flies to explore how epigenetic modifications are transmitted from the mother to the embryo.

Stroud was interested in studying epigenetic changes, or chemical modifications that turn genes on and off, in DNA for the glucocorticoid receptor gene that regulates passage of cortisol from mother to fetus.

The alteration of gene activity, called epigenetics, might result from modification of RNA molecules that interact with genes; a modification of the packaging that carries DNA; molecular switches attached directly to the DNA itself; or even something to do with the cell's power - stations, the mitochondria, Baugh said.

A messenger RNA epigenetic modification regulates stem cell progression from the pluripotent to the differentiated state.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression and looks at chemical modifications of DNA and the proteins associated with it.

However, 15,627 CpG sites in / near ∼ 30 % of all genes exhibited differential methylation in adipose tissue from a case - control cohort of unrelated individuals, supporting a key role for epigenetic modifications in T2D patients.

Plotted together with the DNA methylation from MethylC - seq, the integrated picture of epigenetic modifications was quite striking:

Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

Our work thus contributes to the understanding of aberrant histone modification in peripheral T - cell lymphomas, not otherwise specified and the stratification of a biological subset that can benefit from epigenetic treatment.

Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.

These alterations, technically called epigenetic modifications, can be transmitted from mother to child for generations.