Sentences with phrase «from functional studies»

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Some scientists have criticized TCGA for focusing on gene sequencing while diverting funds from functional studies that can determine which of the hundreds of mutations are most important.

Not exact matches

They range from study of the evolutionary phases of a functional cosmology to the various phases of human cultural development, the emerging ecological age, and the identification of values.

For those not familiar with many recent studies, however, from perspectives other than my own I present a kind of summary — but it is, of course, from a functional point of view.

Stratum Nutrition, a Novus International business focusing on nutrition through functional and specialty ingredients, will be presenting findings from application studies incorporating ApuraGreen kiwifruit paste during the IFT Annual Meeting 13 - 16 July in Chicago.

A study shows, for the first time, how these functional impairments arise: Social isolation during early life prevents the cells that make up the brain's white matter from maturing and producing the right amount of myelin, the fatty «insulation» on nerve fibers that helps them transmit long - distance messages within the brain.

The primary aim of this study was to determine if lower - limb compression garments impact on the functional recovery from distance running.

In the wake of this lobbying, the provision calling for further study of functional ingredients was dropped from the Senate version of the bill.

«What has emerged from our study as well as from other work on introgression is that interbreeding with archaic humans does indeed have functional implications for modern humans, and that the most obvious consequences have been in shaping our adaptation to our environment — improving how we resist pathogens and metabolize novel foods,» Kelso says.

Focusing on the neural pathway from the brain's prefrontal cortex to the amygdala, they combined optogenetics — a technique that uses light to control the activity of neurons in living tissue — with behavioral testing, a methodology that allows researchers to study functional connections between different regions of the brain.

Using data from National Database for Autism Research (NDAR), lead author Kristina Denisova, PhD, Assistant Professor of Psychiatry at CUMC and Fellow at the Sackler Institute, studied 71 high and low risk infants who underwent two functional Magnetic Resonance imaging brain scans either at 1 - 2 months or at 9 - 10 months: one during a resting period of sleep and a second while native language was presented to the infants.

Anatomical studies confirmed the importance of the right rehabilitation schedule: Depending on the therapeutic design, different patterns of new nerve fibers that sprouted into the cervical spinal cord from the healthy part of the brain and thus aid functional recovery to varying degrees were apparent.

The fNIRS scans indicated that the concussed brain activated at a lower threshold and drew from a wider area — a sharp contrast from earlier functional magnetic resonance imaging (fMRI) studies using concussion patients.

Sinha and her colleagues used functional magnetic resonance imaging to study brain activity in people exposed to stimuli ranging from highly stressful — images of mutilated bodies or someone pointing a gun — to neutral, such as a chair, table or lamp.

Our new study has shown that we can go even further: from these co-mutations it is possible to uncover the protein's macrostructure, its fundamental structural and functional units.»

Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on cells derived from patients.»

I realize that your «Working Group On Review Of Bioengineering And Technology And Instrumentation Development Research», defined «bioengineering and technology» as encompassing areas such as biotechnology, functional genomics, informatics, chemistry and physics, nevertheless they did not discuss the problems experienced by physicists engaged in basic research on the frontier of physics and biology from the present system of study sections.

In a new study the PhD students Jan Hoeber, Niclas König and Carl Trolle, working in Dr.Elena Kozlova's research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord.

They also published findings from an animal study showing that the effect of stem cell therapy following heart attack is indirect — the stem cells themselves do not survive long after being placed in the heart, but they cause enduring effects by stimulating the rapid growth of surviving heart tissue and attracting stem cells already in the heart, which mature into functional heart cells.

«One of the surprising findings from this study was that even the subjects who had extreme exposure — two subjects who went to a music festival with 16 hours of exposure at 101 to 103 dBA (A-weighted decibels), which is around 1,000 percent of the daily occupational noise limit — had only temporary changes on some functional tests, with no evidence of permanent pathology,» Le Prell said.

Building on this research in their latest study, the team analysed liver samples from 2000 patients with Hepatitis C, using state - of - the art genetic and functional analysis, to determine the specific IFNL protein responsible for liver fibrosis.

A previous study from the MGH team found that injecting B cells into cardiac tissue damaged by a heart attack improved structural and functional recovery in an animal model.

But neither data from brain scanners — functional magnetic resonance imaging — nor clinical studies of patients with implanted electrodes have explained exactly how the cells in these face patches work.

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

Data for the study was obtained from dozens of published peer - reviewed scientific studies and the Xylem Functional Traits Database, which contains measurements of the hydraulic safety margins for each species as determined through laboratory experiments.

But this is the first time, to my knowledge, that the direct link is established from a novel gene to a novel structure to the invasion of a completely new ecological opportunity,» said Abderrahman Khila, an evolutionary and developmental genomicist at the Institute of Functional Genomics of Lyon, who led the study on the delicate insects called water striders.

Well according to a study in the journal Functional Ecology [Toshie Mizunuma et al., The relationship between carbon dioxide uptake and canopy colour from two camera systems in a deciduous forest in southern England], those images may be more than just pretty pictures.

These results are the fruit of the doctoral thesis «A study of the contents of carotenoids and the phenolic compounds in tomatoes and flowers in the context of functional diet,» by the researcher Elena Coyago Cruz from the Salesian Polytechnic University in Quito (Ecuador), under the direction of Corell and Meléndez.

According to Ralph Adolphs, PhD, Bren professor of psychology and neuroscience at Caltech, a contributing author, «Most data relevant to understanding psychiatric illness is derived from studies that use functional magnetic resonance imaging.

They pooled functional data from 19 published studies, providing a total of 281 patients with BPD and 293 healthy control subjects.

In studying the functional behavior of the brain, from control of muscles to the formation of memories, scientists are using such tools such as electron microscopy, recordings of electrical signals from individual brain cells, and imaging of brain structures and processes using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and high - resolution optical imaging.

The revolution in neuroscience is often characterized as a revolution in new imaging technology.A long overdue reassessment of neuroimaging machines — in particular the functional magnetic resonance imager — has underlined that what you see is not always what you get.A study published this year in Perspectives on Psychological Science noted that many papers in social neuroscience, the field that examines the neurobiology of social behavior, suffered from faulty analyses that produced «voodoo correlations» in their data.

This HDG genome represented the most complete de novo genome assembly to date, and with other omics data resources available from this individual, the work can be used as a benchmark for developing new sequencing and assembly techniques, and for functional studies involving RNA or protein analysis.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

«The concept for the CCRC arose from the needs of young adult ICU patients who we saw leaving the hospital with functional impairments as well as a spectrum of disorders — memory, attention, depression, mood and anxiety — typically not seen in other patients of similar age,» said Dr. Khan, lead author of the study.

Although the research indicates it may someday be possible to regenerate neurons from the body's own cells to repair traumatic brain injury or spinal cord damage or to treat conditions such as Alzheimer's disease, the researchers stressed that it is too soon to know whether the neurons created in these initial studies resulted in any functional improvements, a goal for future research.

In the present study, we demonstrate that a subset of gustatory sensory neurons express functional 5 - HT3 receptors that play a significant role in the neurotransmission of taste information from taste buds to nerves.

Researchers studied more than 1,600 stroke patients with similar stroke severity and functional status when discharged from the hospital.

This, in my opinion, is one of the most compelling parts of this study: in vivo functional validation of a single base change in a noncoding enhancer that's hundreds of thousands of bases away from the gene it regulates.

These results demonstrate robust functional dysregulation that corresponds to the third stage of the addiction cycle (craving) and parallel emerging findings from functional imaging studies in human addicts.

In this study, we used an in vivo strategy to determine if functional retinas could be generated from a defined population of pluripotent Xenopus laevis cells.

Now, in a study published in Stem Cells, the Ahmad group report on the creation of RGCs from adult corneal limbal cells using this methodology, and demonstrate iPSC - derived RGCs to be functional and safe in transplantation experiments [3].

These feeder cells, derived from zebrafish testicular cancer cell lines, promote the growth of spermatagonia and stimulate them to mature into functional sperm,» said Dr. Sakai, the study's senior author and a reproductive biologist.

Dr. Polonis» lab has focused for many years on functional antibodies elicited by natural infection and by vaccination, utilizing samples from multiple natural history cohorts and vaccine studies; her lab is currently performing an extensive analysis of pseudovirus neutralizing antibodies in the large RV144 follow - on trial, RV306.

A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.

«This step opens up an opportunity to take cells from patients with genetic blood disorders, use gene editing to correct their genetic defect, and make functional blood cells,» said Ryohichi Sugimura, a doctor at Boston Children's Hospital and lead author of one of the studies.

Researchers are building a database of DNA sequence, functional and epigenomic information, and clinical data from studies on type 2 diabetes and its macro - and microvascular complications, and creating analytic tools to analyze these data.

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

Another study from Sweden even demonstrated that the specific microbiome composition occurring in Alzheimer's patients induces the development of disease - specific amyloid - beta plaques, thereby establishing a direct functional link between the gut microbiome and Alzheimer's disease — at least in mice.

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard...