Sentences with phrase «from genetic association studies»

GWAS Central; summary level genotype - to - phenotype information from genetic association studies.

Not exact matches

The new framework enhances the ability to detect genetic associations and interactions by taking advantage of data from other genomic studies of the same population.

With a grant from the Morris Animal Foundation, Antczak, his collaborators Samantha Brooks and Ann Staiger from the University of Florida, and the rest of the team applied a genomewide association study to compare the genetic makeup of horses with and without sarcoid tumors at more than 50,000 sites in the equine genome.

In conducting their study, which includes detailed behavioral, medical and genetic observations of 14 boys with CS from 12 families, the team of scientists and physicians worked closely with families of the small but fast - growing Christianson Syndrome Association, including hosting the group's inaugural conference at Brown's Alpert Medical School last summer.

The association study matches genetic variants with a trait by looking at large groups of people with that trait and then compares how their genomes differ from a group without the trait.

To capture uncommon genetic variants, the study used an exome genotyping array to genotype 7,060 epithelial ovarian cancer (EOC) cases and 6,712 cancer - free women from the Ovarian Cancer Association Consortium.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

Scientists for years have looked for the biological roots of the problem using tools such as genome - wide association studies and gene - linkage analysis, which crunch genetic and health data from thousands of people in an effort to pinpoint disease - causing genetic variants.

For a study published in the journal Biological Psychiatry, Ole Andreassen and colleagues compared genetic information from Neanderthals and modern humans and found an association between markers of human evolution and genetic risk for schizophrenia.

Previous genome - wide association studies (GWAS) by the group have identified new genetic risk factors for the higher rates of asthma and poor response to bronchodilator medications seen in these minority populations — in many cases different from risk factors seen in prior studies conducted in European Americans.

«PrediXcan tells us which genes are more likely to affect a disease or trait by learning the relationship between genotype, gene expression levels from large - scale transcriptome studies, and disease associations from GWAS studies,» said study leader Hae Kyung Im, PhD, research associate (assistant professor) of genetic medicine at the University of Chicago.

The study entitled «A multi-national Arab genome - wide association study identifies new genetic associations for Rheumatoid Arthritis», has now been published in the prestigious medical journal Arthritis & Rheumatology; and was supported by grant from the Qatar National Research Fund, a member of Qatar Foundation.

Genetic loci associated with plasma phospholipid n - 3 fatty acids: a meta - analysis of genome - wide association studies from the CHARGE Consortium

It's relatively straightforward to discover genetic associations, but it's another matter to then go from association to function,» explains the study's co-senior author Jose Florez, co-director of Broad's Metabolism Program, associate professor at Harvard Medical School, and chief of the Diabetes Unit at MGH.

In the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophrenia.

With funding for over a decade from the NSF and the USDA, the Rice Diversity Project supports QTL mapping, Genome Wide Association Studies (GWAS), and gene discovery using a suite of open - source genetic, genomic and bioinformatic resources developed in the McCouch lab.

ASHG 2008: Advancing Our Understanding of Genetic Disease: New Findings from Genome - Wide Association Studies ASHG Press Release - November 12, 2008

Genome - wide association study (GWAS) data from a prospective cohort of warfarin - treated patients (n = 711) was also analyzed for genetic variations across the CYP4F gene cluster.

CSGB scientists conduct studies aimed at understanding complex genetic diseases and developing new statistical methods and software to analyze data sets emanating from large - scale genetic association and linkage studies.

We will provide a brief overview of results ranging from common, to low - and rare - frequency variant - trait association studies, studies leveraging the diversity across populations, and studies harnessing the power of genetic and genomic approaches to gain insights into the biological underpinnings of these traits.

Methods: We did a genome - wide association study of 297 P falciparum isolates from Cambodia to investigate the relationship of 11 630 exonic single - nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in - vitro piperaquine 50 % inhibitory concentrations (IC ₅₀ s), and tested whether these genetic variants are markers of treatment failure with dihydroartemisinin - piperaquine.

These non-significant results are arguably due to the study's relatively small sample size for a genome - wide association study that requires multiple testing (ranging from N = 372 — 436 in the high and low trait comparison groups), making it unclear whether the same genetic variants are involved in these sub-domains.

Genetic association studies in the field of psychiatric and psychological genetics have been suffering from inconsistencies in replications of results.

I also study the value of integrating research from high - powered genetic association meta - analyses and richly phenotyped longitudinal cohorts.

In a birth cohort study, risk of psychosis in adulthood was raised by a factor of 4 if the mother, during pregnancy, reported that a baby was unwanted.49 Separation from parents in early life has been found to predict an increased risk of psychosis in genetically vulnerable children, 50,51 and the association between immigrant status and severe mental illness may be at least partially explained by the high rates of early separation in migrant populations.52 Adolescents at high genetic risk of psychosis have also been found to be at increased risk of psychosis in later life if they report adverse relationships with their parents.53