Sentences with phrase «from hematopoietic»

Thus, one can transplant fully allogeneic hematopoietic stem cells and co-transplant, for example, hearts from the hematopoietic stem cell donor to induce lifelong donor - specific acceptance of the transplant, without deleterious immunosuppression [4].

They acknowledge modest benefit from hematopoietic stem cell transplantation in cardiac disease and ameliorative but noncurative outcomes in autoimmune diseases.

Lastly, two sessions dedicated to disease modeling and cell therapy, respectively, will highlight ongoing attempts to study and treat diseases using stem cells from the hematopoietic and neural systems.

Not exact matches

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

One example is the generation of different types of blood cells from their precursors, the hematopoietic stem cells.

Researchers have known that aberrations in the methylation of hematopoietic, or blood - forming, stem cells (HSCs) can prevent them from differentiating into mature blood cells, leading to AML.

These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.

«By being able to distinguish benign from malignant aging based on distinctive RNA splicing patterns, we can develop therapeutic strategies that selectively target leukemia stem cells while sparing normal hematopoietic stem cells,» she said.

They also found that when under stress from chemotherapy, megakaryocytes signaled fibroblast growth factor 1 (FGF1), to stimulate the proliferation of hematopoietic stem cells.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

Researchers in Germany have demonstrated that hematopoietic stem cell (HSC) transplants can be improved by treatments that temporarily prevent the stem cells from dying.

Subsequently, the hematopoietic system has to be replaced with stem cells from the blood of a healthy donor.

The only curative treatment is a hematopoietic (blood - forming) stem cell transplant from a compatible donor.

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

Review of «Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells» from STEM CELLS by Stuart P. Atkinson

This process (see figure) started with spin - embryoid body (spin - EB) formation from cultures of single - cell hiPSC suspensions in 96 well plates, and the subsequent addition of BMP4 and FGF - 2 to induce mesoderm differentiation, and then VEGF and SCF to induce hematopoietic differentiation.

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow.

Hematopoietic stem cells (HSCs) can be isolated from the bone marrow and are characterized by the expression of Lin - CD34 + CD38 - CD90 + CD45RA -.

Results showed rapid hematopoietic recovery and no signs of toxicity from MSC infusion.

One chapter describes the clear clinical applications of hematopoietic stem cells from cord blood.

One important line of our work has revealed mechanisms how hematopoietic stem cells can generate more myeloid cells to protect transplant recipients from lethal infections.

A major focus is the characterization of homing of hematopoietic stem cells to specific niches from which they can be mobilized or start differentiating.

Isolation and characterization of mesenchymal adult bone marrow stem cells (MSC) and hematopoietic stem cells (HSC) from healthy donors and patients with leukemia.

In order to modify or expand primary human hematopoietic cells, they must first be isolated from the body and then cultured under conditions that allow for their modification.

Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson

Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.

Recent papers published by groups from UC Berkeley and Stanford University have described methods for the genetic manipulation of primary human hematopoietic stem and progenitor cells (HSPCs) that require them to be maintained in vitro for anywhere from 24 hours to more than a week.

Review of «Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells» from Stem Cells by Stuart P. Atkinson

Investigators, clinicians, laboratory technicians, clinical research professionals, nurses, pharmacists, administrators, and allied health professional attendees benefit from the full scientific program that addresses the most timely issues in hematopoietic cell transplantation.

STAP (stimulus - triggered acquisition of pluripotency) cells were thought to be engineered stem cells created when hematopoietic stem cells from the spleens of newborn mice were exposed to an acid environment, triggering their conversion from multipotent somatic cells to pluripotent - like stem cells.

Title: Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self - Renewal during Homeostasis and Repair Authors: Wilson A, Laurenti E, Oser GM, van der Wath RC, Blanco - Bose WE, Dunant C, Bockamp E, Liò P, MacDonald HR, Trumpp A Date: 2008 Publication Details: CELL, 135: 1118 - 1129

This is why transplants of HSCs (from bone marrow) are also used to treat cancers of the hematopoietic (blood) system, such as leukemia or lymphoma.

Role of hematopoietic stem cells in steady state hematopoiesis It is remain not very clear if all blood cell types are developed from one hematopoietic stem cell (HSC) in normal hematopoiesis, because of limitations of conventional transplantation models.

The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation.

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

The Treatment: Autologous hematopoietic stem cell transplantation (AHSCT) is an aggressive procedure which involves collecting stem cells from an...

The patients» biopsies she sees are mainly from child recipients of oncologic and hematopoietic stem cell transplants.

In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).

Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unrelated donor.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

However, here, we used a well - defined hematopoietic cell population derived from ES cells, and we showed the kinetics of their MHC expression.

While Wang et al. [12] recently showed no expansion advantage of hematopoietic cells derived from human ES cells, Bowles and colleagues [13] saw increased expansion.

Although, remarkable progress has been made in the in vitro development of T cells from ES cells [6], [7], this has not been the case for other hematopoietic cell lineages.

One type of stem cell transplant, autologous hematopoietic stem cell transplantation, uses stems cells from your own bone marrow, or from external umbilical cord blood.

Not to bore you with the science, but it seems our bone marrow produces more hematopoietic stem cells — the ones that lead to white blood cells — during our peak years, though it is important to note that this doesn't protect us from injury or malnutrition, and it doesn't last.

Red marrow in the long bones is the pool from which hematopoietic stem cells originate.