Researchers at Geron, meanwhile, had successfully derived
neurons from human embryonic stem cells and were pursuing research that would eventually look to repair the damage caused by spinal - cord injuries, a possible use for embryonic stem cells that was much touted at the time.
The new study, published in the journal Stem Cell Reports, describes the use of human induced pluripotent stem cells (iPSC) to produce an unlimited supply of pure keratinocytes — the predominant cell type in the outermost layer of skin — that closely match keratinocytes
generated from human embryonic stem cells (hESC) and primary keratinocytes from skin biopsies.
Injecting neurons derived
from human embryonic stem cells into rats suffering from Parkinson's - like symptoms allowed the animals to regain movement, according to a study led by neurologist Steven Goldman of the University of Rochester Medical Center.
Da Cruz and his team grew replacement RPE cells
from human embryonic stem cells on a thin plastic scaffold, before transplanting the tissue into the back of each volunteer's eye.
Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for generating neurons
from human embryonic stem cells rejected by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».
For example, animal studies have shown that neurons derived in the
lab from human embryonic stem cells improve Parkinson's symptoms; however, any residual stem cells associated with those neurons could form masses of unwanted cells.
Next, the research team will examine specifically whether these liver cells
obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.
It would seem that the California Institute for Regenerative Medicine (CIRM) is not alone as it increasingly moves
away from human embryonic stem cell research (hESCR) and towards adult and other non-embryonic avenues of stem cell research.
A number of recent articles, however, have reported that hiPSCs are, in fact, notably
distinct from human embryonic stem cells in terms of their gene expression, epigenetic profile, proliferative capacity and the susceptibility of their differentiated progeny to cellular senescence and apoptosis [3 — 6].
In the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million immature neurons derived
from human embryonic stem cells into their brains.
Eighteen adults with severe eye disease who were among the first people to receive transplants
created from human embryonic stem cells (hESCs) continue to have no apparent complications with the introduced cells after an average of nearly 2 years, according to the latest status report on their health.
«The results are highly encouraging,» says Pete Coffey of University College London, who heads a project to treat people with age - related macular degeneration using tiny patches of retinal pigment epithelial cells made
from human embryonic stem cells.
Trials of cells made
from human embryonic stem cells are also poised to begin in people with type 1 diabetes and heart failure, the first time embryonic stem cells have been used in the treatment of major lethal diseases.
Two weeks after the experimental myocardial infarctions, the Seattle researchers injected 1 billion heart muscle cells derived
from human embryonic stem cells, called human embryonic stem cell - derived cardiomyocytes, into the infarcted muscle.
In the study, the investigators used GABAergic inhibitory neuron precursors called MGE - like cells that were derived
from human embryonic stem cells.
The patch is made of eye cells made
from human embryonic stem cells, and it has been designed for treating the «dry» form of macular degeneration, which accounts for 90 per cent of all cases, and affects 1.7 million people in the US.
Twelve people left almost blind by a hereditary condition that strikes in childhood are to receive the world's first eye therapy derived
from human embryonic stem cells (hESCs).
Twelve people with Stargardt's macular dystrophy will be treated with retinal cells made
from human embryonic stem cells (hESCs) in the hope of improving, or at least halting loss of sight.
A person with spinal injuries today went down in history as the first to receive a treatment derived
from human embryonic stem cells (hESCs).
The paper, which described how sperm - like cells could be derived
from human embryonic stem cells, was published online on 8 July by Stem Cells and Development.
«Giant leap for diabetes:
From human embryonic stem cells to billions of human insulin producing cells.»
What we discovered is that we can create literally millions or billions of
these from human embryonic stem cells.
One is using cells derived
from human embryonic stem cells to treat spinal cord injury (although funding problems have stopped the trial enrolling new patients) and another is testing a treatment for age - related macular degeneration.