Sentences with phrase «from humans and mice»

Moreover, these joint data from humans and mice provide the first evidence that neurodegenerative effects of airborne PM may involve gene - environment interactions with APOE ɛ4, the major genetic risk factor for pathological brain aging and AD.

In their latest research, the Joslin team performed many experiments to explore the actions of these two proteins, called centromere protein A (CENP - A) and polo - like kinase - 1 (PLK1), in mice and in cells from humans and mice.

Furthermore, they integrated single - cell datasets of pancreatic tissue from humans and mice, thereby identifying 10 cell types that were shared across species and defining the evolutionary changes occurring in each group.

To make this discovery, the researchers stimulated isolated neutrophils from humans and mice with nicotine and could measure a dose - dependent release of inflammatory molecules.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

Not exact matches

Data from experiments on phytic acid using mice and other rodents can not be applied to humans.

Hassles such as buying paper towels or searching for the perfect used car that used to require legwork, human interaction, and possibly even wearing pants can now be done with a click of a mouse from one's own living room.

This need stems from the mammalian brain, a commonality that affects cats, dogs, mice... and humans!

This region has the highest oxytocin levels in the brain and has high levels of oxytocin receptors across all species from mice to humans.

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

«Apart from humans and some domestics that humans brought with them, mice are the most globally distributed mammals,» he says.

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

Dr. Issa's team made their discovery after first examining methylation patterns on DNA in blood collected from individuals of different ages for each of three species — mouse, monkey, and human.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The Salk team therefore took human brain organoids that had been growing in lab dishes for 31 to 50 days and implanted them into mouse brains (more than 200 so far) from which they had removed a tiny bit of tissue to make room.

Mice ranged in age from a few months to almost three years, monkeys from less than one year to 30 years, and humans from age zero to 86 years (cord blood was used to represent age zero).

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

To see whether this also applies to humans, the team engineered stem cells from people with and without Down's syndrome and injected them into mice.

The «training data» were generated from 78 mice infected with influenza or the cytomegalovirus (CMV) and 32 humans infected with flu, CMV or the Epstein - Barr virus.

And the transformed cells proved to be very similar to actual stem cells from both mice and humaAnd the transformed cells proved to be very similar to actual stem cells from both mice and humaand humans.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

When they analyzed microbes found in fecal samples collected from mice and humans at different times of day, they discovered rhythmic fluctuations in the abundance of microbes and their biological activities.

«Finding these similarities and studying the aspects of mouse biology that may reflect human biology, allows us to approach the study of human illnesses in a better way,» affirms Bing Ren, one of the principal authors from the ENCODE Consortium and a lecturer in molecular and cellular medicine at the University of California — San Diego.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

Several species, including Arabidopsis, rice, mice and humans, copy a surprising amount of RNA from the «wrong» DNA strand — that is, the strand opposite the one that specifies a protein.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

That's the tantalizing finding from a new study published today that reveals a way that mice — and potentially humans — can control the makeup and behavior of their gut microbiome.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

The same observations were made in organoids (artificially grown masses of cells that resemble an organ) created from unique basal progenitor cells that were isolated from the gastroesophageal junction in mice and humans.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

P: They are still a far cry from humans, and you haven't had huge increases in the life span of mice.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Concerned that the immune systems of clean mice might not be good proxies for the human immune system — no human is brought up in such clean conditions and fed such clean food — they housed lab mice with mice from a pet store.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

To see if they would suffice to make H5N1 infection less severe, Webby and his co-workers injected mice with DNA for the neuraminidase gene from human H1N1, one of three flu subtypes covered by this winter's flu shot.

As reported in a paper published online in the New England Journal of Medicine, researchers from Penn Medicine, Regeneron Pharmaceuticals, and a group of international collaborators studied ANGPTL3 in both humans and mice.

Researchers have isolated exosomes from tumors and from blood of patients with breast cancer, and from blood of mice with human tumors grown after breast implantation in mice, called ortoxenogratfs.

The two reports also showed that Zika virus infected and damaged neuronal stem cells harvested from mice and humans.

The normal mice's brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.

Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved from mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver disease,» explained Dr. Gouon - Evans.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The mice benefited from human stem cells called glial progenitors, immature cells poised to become astrocytes and other glia cells, the supposed support cells of the brain.

While human - animal chimera work is still in its infancy (and faces ethical and funding hurdles, see sidebar), hybrids of rats and mice are already hinting that growing an organ from