High PI and DBI equals short lifespan MLSP despite mitochondrial Glutathione and Thioredoxin trying its best to scavenge membrane Hydroperoxides formation
from hydroxyl radical stealing hydrogen atom from unsaturated fatty acids (initiating lipid peroxidation propagation forming highly mutational reactive aldehydes (MDA, MDA - TBARS), alkenals (4 - HNE), methylglyoxals (creating glucosepane, MDA - Lys, CML, pentosidine, CEL, furosine from Amadori).
Not exact matches
«For example, in the future methane levels could increase as a result of increased natural gas and energy use, climate change feedbacks and / or a decrease in the global abundance of the
hydroxyl radical, which chemically removes methane
from the atmosphere.»
«All three of these molecules are removed by the same process — reaction with
hydroxyl,» a
radical formed
from water in the atmosphere, explains Nobel Prize - winning chemist F. Sherwood Rowland, who participated in the research.
The two most common ways of creating what is a false alkalinity are use of bicarbonates or drinking water
from machines that make alkaline water by chemically splitting water into a retained
hydroxyl radical that is alkaline and an acid proton that is flushed away.
In the case of alkaline water,
hydroxyl radicals are so caustic that the body has multiple mechanisms for preventing such molecules
from getting to the cells or systems of the body.
But when you have excessive iron, it catalyzes the formation of excessive
hydroxyl free
radicals from the peroxide, which decimate your mitochondrial DNA, mitochondrial electron transport proteins and cellular membranes.
These free
radicals (such as: superoxide,
hydroxyl radical, and peroxynitrite) are controlled by antioxidant systems and when these systems can't cope with the amount of free
radicals produced these free
radicals scavenge for electrons
from proteins, cell membranes, and DNA.
[3] In a recent in vitro study, researchers
from the department of pathology at Okayama University Medical School in Japan found that Asian ginseng extract inhibited
hydroxyl radical formation.
This differs
from gases like methane which do have a «real» lifetime due to reactions with
hydroxyl radicals, where for any given steady state anthropogenic methane emissions are, a stabilized concentration value will eventually be reached.
Third, although many of the individual steps have been established experimentally (18), surprisingly, the mechanism of production of MSA
from OSC gas phase oxidation by
hydroxyl radicals (OH, daytime) and nitrate
radicals (nighttime) remains unclear (31).
In the Supplementary Report (IPCC, 1992) to the FAR, the indirect chemical effects of CO, NOx and VOC were reaffirmed, and the feedback effect of CH4 on the tropospheric
hydroxyl radical (OH) was noted, but the indirect RF values
from the FAR were retracted and denoted in a table with «+», «0» or «--».