Others have suggested that the apparent transdifferentiation might result
from immature cells fusing with mature cell types from other tissues.
Not exact matches
These dots are called «milia» and are caused
from immature oil glands and dead skin
cells being trapped underneath your baby's skin.
What's more, the live
cells in breast milk that protect babies
from infection can be even more important for premature babies: Preemies face a higher risk of infection because their immune systems are particularly
immature.
The first complete, real - time recording of an egg
cell eliminating its centrioles shows the starfish egg
cell handles mature «mother» centrioles (green) differently
from immature «daughter» centrioles (purple).
In the image, a bladder
cell (blue) that has been exposed to G. vaginalis is dying and detaching
from its neighboring
cells (teal), revealing
immature cells below (purple).
Vidaza,
from Pharmion, was approved for myelodysplastic syndromes, a bone marrow disorder marked by rapidly dividing
immature blood
cells that no longer respond to growth - control mechanisms.
Next, the team exposed
immature immune
cells from the blood of healthy people to the bacteria found in the guts of MS patients.
The mice benefited
from human stem
cells called glial progenitors,
immature cells poised to become astrocytes and other glia
cells, the supposed support
cells of the brain.
This remainder can then be seeded with
immature organ
cells or stem
cells from the intended recipient.
They then purified messenger RNA — a molecule that plays a key role in the production of proteins —
from the
cells in the animals» upper intestines, injected the mRNA into
immature eggs
cells, and looked for changes in iron uptake.
Scientists can create these seemingly magical
cells from any
cell in the body by introducing four genes, in essence turning back the cellular clock to an
immature, nonspecialized state.
Klingelhutz and his team immortalized
immature precursor fat
cells by adding in two genes
from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of
cells» telomeres — the pieces of DNA that protect chromosome tips
from deterioration.
Then came a new step: They carefully extracted the fragile,
immature eggs and some surrounding
cells from the follicles, and allowed them to further mature on a special membrane in the presence of more growth - supporting proteins.
The human equivalent to the mouse
cells, however, would have to be isolated
from fetal retinas, posing the familiar problem of finding a source for the
immature cells.
Immature cells from the lab - grown structures can integrate into adult eyes.
Last year, Robin Ali of University College London and colleagues demonstrated that
immature retina
cells from newborn mice could form rod
cells — a type of light - gathering
cell — that wire into the retinas of night - blind adult mice (SN: 5/19/12, p. 13).
To understand how the bacteria affected the immune system, the researchers grew L. reuteri in liquid and then transferred small amounts of the liquid — without bacteria — to
immature immune
cells isolated
from mice.
Another unexpected discovery, Dyer said, was the point during development when the
immature cells transition
from making new tissue by dividing rapidly, to differentiating into a mature retinal neuron.
By immersing stem
cells harvested
from men's bone marrow in a cocktail of chemicals that mimic the environment of the testes, Nayernia and his team turned the stem
cells into
immature sperm.
Nayernia says it's possible that transplanting his
immature sperm
cells into human testes could make them functional — but he's awaiting permission for that experiment
from his institute's ethics board.
The researchers tested their technique on such cultivated stem
cells of both a mature and
immature type, and on donated human embryos left over
from IVF treatments.
They saw HIV - infected human immune
cells, caught virus particles in the act of budding
from such
cells, and also found groups of free
immature and mature viruses.
In the strongest test of their potential yet, six people with heart failure will be treated in France with a patch of
immature heart
cells made
from hESCs, and 40 people with diabetes in the US will receive pouches containing
immature pancreas
cells made
from hESCs.
By comparing the DNA methylation in
immature and mature muscle
cells from healthy individuals, Cajsa Davegårdh discovered that the actual degree of methylation had a major impact on the maturation process.
Glioblastoma
cells from patients that could be linked by the gene signature analysis with an
immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma
cells that were associated with a more differentiated
cell of origin.
In out - of - the - body gene therapy, researchers take blood or bone marrow
from a patient and separate out
immature cells.
Shortly after this discovery K. Unsicker and his colleagues at Johns Hopkins University found that
immature chromaffin
cells obtained
from the medulla (inner part) of the adrenal gland and cultured in the presence of NGF acquire the biochemical and morphological properties of sympathetic neurons.
Drawing upon the
cell culture expertise of Noriyoshi Sakai, Ph.D., and Kayoko Kurita, of Fukui Prefectural University, the Japanese - U.S. team developed a system that enables
immature sperm
cells, or spermatagonia, taken
from male zebrafish to survive long enough in vitro that they can receive foreign genes inserted by a retrovirus.
Jason Lee / Reuters In the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million
immature neurons derived
from human embryonic stem
cells into their brains.
It could also distinguish dead
from living
cells, spot neurons within groups of
cells that included astrocytes and
immature dividing
cells, and even tell a dendrite
from an axon.
The relationship between cancer and embryonic tissues was first proposed in the 1870s by Francesco Durante and Julius Cohnheim, who thought that cancers originated
from cells in adults that persist in an
immature, embryonic - like state.
In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly
from the
immature CNS [49]--[53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated
from precursor
cells in vitro in order to optimize benefit.
Researchers had developed the technologies needed to create organoids years before — how to grow
cells in culture, how to isolate stem
cells from human tissue, and how to coax the stem
cells, undifferentiated and
immature, to become specific types of
cells at later stages of development.
In a classic experiment, he replaced the
immature cell nucleus in an egg
cell of a frog with the nucleus
from a mature intestinal
cell.
The AUGMENT treatment uses energy - producing mitochondria
from your EggPC
cells, which are
immature egg
cells found in the protective lining of your ovaries.
Salk researchers reprogrammed skins
cells taken
from a sickle
cell disease patient into induced pluripotent stem
cells (iPSCs),
immature cells capable of developing into any type of bodily tissue.
However, it remains unclear whether primate ES
cells including those
from humans can undergo gametogenesis through meiosis in vitro, although
immature germ
cell differentiation
from primate ES
cells has been reported [5], [6], [7].
The ViaCyte product contains
immature beta
cells, grown
from the embryonic stems
cells.
Specifically, we're focused on stem
cell maturation — taking a
cell from an
immature to a more mature state so that it acts as a better substrate for adult tissue functions.
Grape leaves boost your intake of vitamins, and provide a particularly rich source of the fat - soluble vitamins A and K. Vitamin A helps your
cells develop, guiding their development
from non-functional
immature cells into specialized
cells that become a part of functional tissue.
When white blood
cells multiply in an abnormal and uncontrolled way, these
immature cells take over, literally crowding the bone marrow thereby preventing it
from producing healthy blood
cells and causing a shortage of red blood
cells.
The complete blood count (CBC)
from cats with heartworm infection may demonstrate anemia, nucleated erythrocytes (
immature red blood
cells), eosinoophila (increase number of eosinophils, a type of white blood
cell) and basophilia (increase number of basophils, a type of white blood
cell).
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band
cell — type of white blood
cell Baso basophil — type of white blood
cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice
from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating
cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood
cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood
cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood
cells Hb, Hgb hemoglobin — iron rich protein bound to red blood
cells that carries oxygen (anemia, red
cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed -
cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood
cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red
cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed -
cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood
cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood
cell —
immature red blood
cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed -
cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet —
cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood
cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte —
immature red blood
cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood
cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood
cell count (infection, inflammation, bone marrow suppression)