Reduced levels of secreted IL - 22 in heterogeneous lymphocyte mixtures of Rag1 - / - splenocytes could be due to another cell affecting ILC3 production of IL - 22 and / or
modulation in IL - 22
from other innate
immune cells that have been reported to produce low levels of IL - 22, such as DCs or neutrophils [22, 42, 43].