Sentences with phrase «from knockout mice»

Nadia Nabil Haj - Yasein Roles of aquaporin 4 and Kir4.1 in brain water and potassium homeostasis: lessons from knockout mice Faculty of Medicine, University of Oslo, 28 February 2012 Supervisor: Erlend Arnulf Nagelhus

Roles of aquaporin 4 and Kir4.1 in brain water and potassium homeostasis: lessons from knockout mice

Mouse embryonic stem cells with one allele of Melk inserted with lacZ and neomycin - resistance genes between exon 2 and 3 were obtained from the Knockout Mouse Project (KOMP; ID: CSD33136).

Not exact matches

Normal mice who received marrow from the Hoxb8 «knockouts» groomed themselves compulsively.

«The next thing to do is to generate a knockout mouse model for further in vivo analysis, as the ultimate goal of our research is to move from bench to bedside, and generating a mouse model is a key step during this long journey,» Shi said.

An international team of researchers has identified a cause for chronic bad breath (halitosis), with the help of gene knockout mice from the UC Davis Mouse Biology Program.

In this cross section of a kidney from a young FAN1 knockout mouse, cell nuclei are stained purple.

In observing kidney cells from the FAN1 knockout mice, the researchers noticed that their nuclei were abnormally large.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so - called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced.

Tom Bebee PhD, a postdoc in the Carstens lab and Rohacek compared RNA sequences from the cochleae of normal versus Esrp1 knockout mice.

C57BL / 6 (H - 2b) and CD4 knockout (C57BL / 6 - Cd 4 , H - 2b) mice were purchased from The Jackson Laboratory (Bar Harbor, ME) and maintained in pathogen - free animal facilities.

The IMPC envisages a ten year programme to undertake a broad - based, systematic genome - wide phenotyping project of knockout mice generated from the embryonic stem cell mutant resources developed by the International Knock - out Mouse Consortium (IKMC).

KOMP2 and IMPC researchers will begin by creating lines of knockout mice from embryonic stem cells produced by KOMP.

BALB / c corneal allografts were transplanted to C57BL / 6 beige nude mice that received either CD8 − or CD8 + T cells from C57BL / 6 CD4 knockout (KO) mice that had rejected BALB / c corneal allografts.

Once each knockout mouse is phenotyped, researchers can obtain information on what knockout mouse lines are available and how to order them from the University of California Davis KOMP Repository.

Up to now, all models have been generated from ES mutant cells with conditional potential generated by the International Knockout Mouse Consortium (IKMC).

Moreover, we found that T cells from double - knockout (DKO) mice did not demonstrate enhanced tumor activity above that observed in DGKζ single - knockout (KO) mice.

Researchers have produced knockout mice with characteristics similar to humans suffering from a wide range of disorders, including cancer, heart disease, neurological disorders and even obesity.

In order to build upon the acquisition of knockout mice available from the private sector, the NIH in September issued a set of requests for applications to establish a Knockout Mouse knockout mice available from the private sector, the NIH in September issued a set of requests for applications to establish a Knockout Mouse Knockout Mouse Project.

Meehan et al., (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

GMC strategy: To develop and offer a large scale standardised and comprehensive phenotypic analysis of mouse mutants from various sources (e.g. transgenic lines, knockout mice, ENU mutants or endonuclease mediated mutations)

And a third clue emerged from their studies: One strain of the knockout mice showed sensitivity to sunlight — a characteristic of human lupus patients that produce antibodies against the Ro protein.

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

Evidence from mouse knockout models and human mendelian disorders suggest that these transcription factors have a function in determining cell identify in the developing breast.

From 2012 onwards the IMPC is continuing the task to generate knockout mice and phenotype the remainder of the 20,000 plus genes in a worldwide coordinated initiative.

Awareness about 2 important publications from IMPC consortium 1 - The analysis of IMPC database that uncovers 360 new human disease models has just been published: Meehan et al., (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

(A) Knockout mice are indistinguishable from those of wild type in morphology and size.

Under the license agreement with Lexicon, researchers who receive the knockout mice lines through NIH are free to publish any results from research involving the line and also to seek patent or other intellectual property protection for any of the inventions or discoveries resulting from such research.

Information here is excerpted from the following publication: A mouse knockout library for secreted and transmembrane proteins, Tang T, et al, Nature Biotechnology, advanced online publication 20 June 2010 (DOI 10.1038 / nbt.1644)

Analyses of macrophages from Tet2 knockout mice showed elevated expression of several chemokine and cytokine genes that contribute to atherosclerosis.

Hypercholesterolemia - prone mice that were engrafted with bone marrow obtained from homozygous or heterozygous Tet2 knockout mice had larger atherosclerotic lesions in the aortic root and aorta than did mice that had received control bone marrow.

EMMA strains produced from ES cells generated by the International Knockout Mouse Consortium (IKMC) are displayed on the EMMA strain list as soon as germ - line transmission has been achieved and the genotype of the pups has been confirmed.

96/3: 45 RNF12 is essential for X-inactivation in female mouse embryonic stem cells, is required for female mouse development, and might be a target for future therapies to treat X-linked disorders in females: Evidence from a mouse knockout model.

They used knockout mice — mice in which specific proteins were deleted from the genome — to classify vitamin K - dependent and selenium - dependent proteins as «essential» (if the knockout mouse died) or «nonessential» (if the knockout mouse was merely sickly).