Sentences with phrase «from laboratory mouse»

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

In the October issue of Cell Stem Cell, Marius Wernig, MD, PhD, a NYSCF — Robertson Investigator at Stanford University, reported on the successful transformation of mature liver cells from laboratory mice into functioning neurons.

Not exact matches

«The 20th century's Thomas Edison has stepped from the stage... the scope of the technologies that sprang from or were transformed by Jobs's Apple laboratories — the Mac, the mouse, the laptop, Pixar, iTunes, iPod, iPhone, iPad — is awesome, as was that from Edison's Menlo Park.»

Researchers at the University of Michigan's Mary H Weiser Food Allergy Center have developed a nasal vaccine that protects laboratory mice from allergic reactions upon exposure to peanuts, after just three monthly doses.

Researchers at the University of Michigan's Mary H Weiser Food Allergy Center have developed a nasal vaccine that protects laboratory mice from allergic reactions upon exposure to peanuts, after just...

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

The scientists then exposed humanized laboratory mice to either brain or skin extracts from two of the CJD patients.

There's been a growing realization among diabetes researchers that human islet development differs significantly from islet development in typical laboratory animals like mice.»

In this study, published in the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this study.

Recent laboratory work from Virginia Tech University scientists found that when mice are exposed, both males and females have some unsettling impacts, such as weaker sperm and decreased ovulation.

For the new study, researchers in Diamond's laboratory, led by first author Helen Lazear, PhD, now at the University of North Carolina at Chapel Hill, tested five strains of the Zika virus in the mice: the original strain acquired from Uganda in 1947; three strains that circulated in Senegal in the 1980s; and the French Polynesian strain, which caused infections in 2013 and is nearly identical to the strain causing the current outbreak.

These sparks are created when billions of zinc atoms shoot from thousands of small pouches nestled just beneath the surface of a mouse egg cell, researchers from Northwestern University and Argonne National Laboratory report December 15 in Nature Chemistry.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

Anthony St. Leger, Ph.D., research fellow in Caspi's laboratory, was able to culture bacteria from the mouse conjunctiva, the membrane that lines the eyelids.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cells.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

Rolls studied laboratory mice that had been gently handled for four hours to prevent them from sleeping while their comrades dozed.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

Next, the scientists cloned the gene from the prairie vole's vasopressin receptor and implanted it in an embryo of the less sociable laboratory mouse.

They found that one particular type of antioxidant in cocoa prevented laboratory mice from gaining excess weight and lowered their blood sugar levels.

Researchers demonstrated that the drugs pemetrexed and gemcitabine killed cells from mouse and human brain tumors, called group 3 medulloblastoma, growing in the laboratory.

A team in the laboratory of Atsuo Ogura at the National Institute of Infectious Diseases in Shinjuku, Tokyo, cloned 12 mice by removing nuclei from testis cells and inserting them into enucleated egg cells.

The following strains of male mice were purchased from The Jackson Laboratory at 8 weeks of age: IL - 15Rα — KO mice (stock no. 003723; n = 20); B6129SF2 / J background control (101045; n = 16).

This is a visualization of the process of transferring gut microbiota from wild mice to laboratory mice.

They noticed that mice purchased from Jackson Laboratory (JAX) tended to have a robust spontaneous immune response to small melanoma tumors implanted under their skin.

But laboratory mice aren't random house mice plucked from a field or basement.

That's because most studies on single human brain cells use dead rather than living tissue, and many others rely on cells from common laboratory animals, especially mice.

Unlike many other cellular and physiological processes, human reproduction varies in significant ways from that of common laboratory animals like mice or fruit flies.

In 1969 V. Bocchini and Pietro U. Angeletti at the Laboratory of Cell Biology in Rome devised a method for purifying NGF from mouse salivary glands.

Unless otherwise noted, all mice were obtained from The Jackson Laboratory (Bar Harbor, Maine, USA) at 6 — 8 weeks of age and housed in ventilated Plexiglas cages (one to three animals per cage) within a pathogen - free barrier facility that maintained a 12 - hour light / dark cycle.

In the mid-1990s, Woloschak had worked on samples from 7,000 beagles and 50,000 mice that had been irradiated in experiments at the Argonne Research Laboratory in Illinois between 1969 and 1992.

Four generations later, the mice still carried either the wild microbiomes or the control laboratory microbiomes passed down from their foremothers.

For example, we showed in collaborative work with Jeffrey I. Gordon's laboratory at Washington University in St. Louis last year that transferring the microbes from an obese person into mice raised in a bubble with no microbes of their own resulted in fatter mice.

NSG (NOD.Cg - PrkdcscidIl2rgtm1Wjl / Szj) mice, 8 — 9 weeks old at time of initial injection, were derived from breeders purchased from The Jackson Laboratory (Bar Harbor, ME).

Six - week - old male CD45.2 + (C57BL / 6J) recipient mice and syngeneic CD45.1 + (B6.SJL Ptprca Pep3b / BoyJ) donor mice were purchased from The Jackson Laboratory.

The catalog of mouse and human genes yielded by these genome projects will cut years of time from otherwise painstaking laboratory research.

Carried out in cells in the laboratory, in mice and in samples from patients» tumours, the researchers showed this «safe haven» lets melanoma cells turn on a parallel set of cell signals that helps them survive.

For transplant experiments, CD45.2 + (C57BL / 6J) recipient and CD45.1 + (B6.SJL Ptprca Pep3b / BoyJ) donor mice were purchased from The Jackson Laboratory.

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

C57BL / 6 (H - 2b) and CD4 knockout (C57BL / 6 - Cd 4 , H - 2b) mice were purchased from The Jackson Laboratory (Bar Harbor, ME) and maintained in pathogen - free animal facilities.

Bar Harbor, Maine — October 21, 2004 — The Jackson Laboratory is pleased to announce that it has received support from the Spinal Muscular Atrophy Foundation to make available the first group of mouse models for spinal muscular atrophy (SMA), a neuromuscular disease and the leading genetic cause of death among infants and toddlers.

Now, new research from the laboratory of Vaijayanti P. Kale (National Centre for Cell Science, Pune, Maharashtra, India) has described a fascinating new approach to return lost functionality to aged mouse HSCs: the transfer of microvesicles (MVs) containing positive regulators of autophagy derived from young mesenchymal stem cells (MSCs)[6].

The Jackson Laboratory maintains a resource of more than 300 PDX mice developed from a range of cancers.

Their content is optimized for genetic mapping in the Collaborative Cross and Diveristy Outbred populations; for discriminating haplotypes from common laboratory strains and substrains; and for evaluating the ancestry of wild - caught mice.

In the April 13, 2007, issue of Science, the research team — led by James C. Lo, an MD, PhD student, in the laboratory of Yang - Xin Fu, MD, PhD, professor of pathology at the University of Chicago — suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease.