Sentences with phrase «from lean mice»

Other studies have demonstrated that microbes implanted from lean mice into overweight mice caused the mice to lose weight.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

Protective antibodies from lean mice also failed to protect obese mice from flu infections.

In the second group, they colonized the intestines with flora from a lean mouse.

Not exact matches

To find out what was going on in the microbiomes of four sets of differently shaped identical twins, researchers transferred some gut bacteria from a lean (human) twin to a sterile mouse: one with no foreign bacteria at all.

The mouse stayed lean, even when they later added some bacteria from the obese twin.

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

In addition, lean mice who received vaccines with adjuvants were protected from severe flu infections.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

The researchers used electron microscopy and other imaging techniques to view thousands of cells from the liver tissue of lean and obese mice.

Based on the observation that obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.

The mice who got microbes from the lean twins stayed lean, the researchers report today in Science.

Microbes from lean people protect mice from excessive weight gain, even when animals eat a high - fat, low - fiber diet.

This is interesting, given that muscle / lean muscle mass ratios of non-skeletal muscle organs from IL - 15Rα — KO mice, such as the heart, spleen, and kidneys, were not significantly different from those of B6129 controls.

Normally, germ - free mice exposed to a mouse with microbial - based obesity would themselves become obese, but we could design a microbial community taken from lean people that protected against this weight gain.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

However, when these organ weights were normalized to lean muscle mass, the organ / lean muscle mass ratios were not significantly different from B6129 control mice (Figure 4, F — H).

Immunohistochemical detection of cells expressing the macrophage - specific antigen F4 / 80 (arrows) in extensor digitalis longus muscles from C57BL / 6J (a and c) Lepob / ob female and (b and d) lean female mice.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

In one study, researchers took microbiome samples from both lean and obese mice and placed them in the gut of neutral mice.

The mice that got their protein from shellfish became slimmer, despite their fat - and sugar - rich diet, and did not lose lean body mass either.

Transplanting gut flora from obese mice into lean mice turned the formerly lean mice fatter... Compelling evidence that gut flora has an important connection to body fat levels.

Additionally, fecal transplant of gut microbes from obese mice to GF mice results in greater adiposity in the GF recipients than fecal transplants from lean donors (2).

Researchers at Washu took identical twins where one was lean and other was obese, same genetic material transplanted the microbes into germ - free mice, and lo and behold, the mouse who received the microbes from the obese twin gained weight without any change in diet.

Actually, the leucine - deprived mice showed no difference in lean mass, from either the control mice or those that were restricted to the same number of (reduced) calories consumed by the leucine - deprived mice.

However — and this part is miraculous — when Dr. Panda and his team restricted the time the mice were fed the exact same crappy diet to 12 hours (instead of allowing them to eat whenever they wanted), none of the negative health benefits occurred; the Time - Restricted Fed mice were 70 % leaner, lived longer and were free from diabetes or heart disease.

To explore whether this was a cause of obesity or the effect of it, another research team gave mice the bacteria from sets of twins where one was obese and the other was lean.

Astonishingly, when germ - free mice are colonized with the gut microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.

The mice that got the bacteria from the obese people gained weight, while mice that received bacteria from the lean people didn't.

And wait we do; despite the lean ninety - minute runtime, Downrange can't quite figure out enough variations on their cat - and - mouse situation to keep the final two acts from devolving into a boring slog.