Sentences with phrase «from mechanistic studies»

Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

Not exact matches

From the in vitro reconstituted Rad3 - Rad26 complex, small - angle X-ray scattering and electron microscopic studies, it is possible to model the quaternary structure and thus bring us closer to a mechanistic understanding Rad3 - Rad26 DNA repair apparatus.

«It makes it much easier for researchers working with barley to be focused on attainable objectives, ranging from new variety development through breeding to mechanistic studies of genes.»

A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

Studies are in animal behavior from mechanistic and evolutionary perspectives by using fruit flies, bees, and other insects.

The study has earned high marks from researchers not on the soy industry's payroll, including Dan Sheehan, PhD and Daniel Doerge, PhD at the FDA's National Laboratory for Toxicological research in Jefferson, Arkansas.who stated, «Given the great difficulty in discerning the relationship between exposures and long latency adverse effects in the human population and the potential mechanistic explanation for the epidemiological findings, this is an important study.

However, a large proportion of this mechanistic evidence is limited to indirect observations and / or has come from rodent studies requiring translation into humans.

For the correlative and mechanistic approaches, studies and insights from the present give rise to the assumption that the same relationships will hold in the future.