Sentences with phrase «from model organisms»

Insights from model organisms have long helped scientists understand the biology behind such genetic diseases, but in recent years model organism researchers have become even more directly involved in diagnosing the millions of people affected — and in searching for treatments.

Systems biology and bioinformatics analyses are employed to compare research results from model organisms with human aging to develop models and predictions for causative molecular mechanisms and circuits that influence human aging.

The Role of the Genome Project in Determining Gene Function: Insights from Model Organisms G.L.G. Miklos and G.M. Rubin Cell (1996) 86:521 - 529

Here we show the usefulness of combining survey sequencing with dense radiation - hybrid (RH) maps for extracting maximum comparative genome information from model organisms.

The editors encourage submission of original research findings from all areas within the broad field of immunology from all model organisms, including humans.

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organism to patients.

Not exact matches

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

Rather they work from an S - O - R (stimulus - organism - response) model, which recognizes that most people have some ability to choose among their options.

Whitehead makes a point of taking a concept from biology to understand physics instead of interpreting biological organisms from models developed in physics.

Dennis has a PhD in genetics / developmental biology from the University of British Columbia and a special interest in studying pattern formation and cell - cell communication during tissue development using fruit flies as a model organism.

Birch and Cobb assert that «the ultimate mechanical model involves «disecting the organism down to its constituent controlling mechanisms and building it up from these building blocks» (LL 69).

A year earlier James Watson and Francis Crick had proposed their double - helix model of DNA, the nucleic acid that conveys genetic information from generation to generation in all organisms except certain viruses.

As a proof - of - concept, the researchers cloned more than 3,000 DNA fragments from E. coli bacteria, commonly used as a model organism with a catalogued genome sequence available.

But Bowdidge acknowledges that genetic information from the public domain «is still incomplete for the majority of model organisms.»

Finch's ideas about senescence from his grad school days have also held up: The popularity of the Hayflick model has declined as other research questioned its relevance to aging in whole organisms, and recent studies in long - lived nematodes have confirmed Finch's hunch that brain hormones control aging (see Johnson Review).

To facilitate understanding of the immune system by showcasing innovative advances in the expanding field of immunology, drawing from studies in all organisms and model systems including humans.

A research group from the University of Seville has revealed the role that the protein Rrm3 plays in the repair of breaks that occur during the replication of DNA, by using the yeast Saccharomyces cerevisiae as a model organism.

With his usual style and wit, he discusses the use of methods and models adapted from physics and mechanical engineering to explore how organisms move and function.

Using the Drosophila melanogaster fruit fly as a model organism, the team led by Prof. Dr. Ingrid Lohmann at Heidelberg University's Centre for Organismal Studies was able to show how a special developmental gene from the Hox family influences germline stem cells.

In a 2012 paper in Neuron, based on meetings organized by the Oxnard, California - based Kavli Foundation, Yuste and colleagues laid out a plan to progress gradually from mapping the brain activity of simple model organisms such as the fruit fly to charting the brains of creatures that contain roughly 1 million neurons, such as the Etruscan shrew.

The researchers used proteins from baker's yeast — a model organism for the more complex systems found in animals.

«One of the things that appealed to me [about Fink's lab] was working on more than one model organism, applying insights from yeast genetics to Arabidopsis,» Niyogi recalls.

The project was based on gene expression data from the modENCODE project, which aims to provide the scientific community with a comprehensive encyclopedia of functional elements of the genome of model organisms.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Until now, the human gut has been hard to study because it's so different from those in typical model organisms like mice, so these tiny tummies open up a world of possibility.

This program, McKnight Technological Innovations in Neuroscience Awards, focuses on «how technology may be used or adapted to monitor, manipulate, analyze, or model brain function at any level, from the molecular to the entire organism.»

In order to understand this contradiction, the research group led by Raúl Estévez and Alejandro Barrallo compared genetically - modified zebrafish and mice models — in other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patient.

A new study from the University of Michigan Life Sciences Institute now reveals how some of that cross-talk between tissues occurs in a common model organism.

Using data from a 2008 outbreak of one of the most - feared «superbugs,» and modern genetic sequencing techniques, a team has successfully modeled, and predicted, the way the organism spread between and within dozens of healthcare facilities.

«The key breakthrough came from using a fruit fly model of human ALS and FTD that allowed us to screen these 400 candidates for ones that block brain cell death in a living organism,» says Lloyd.

In addition, the significant number (> 1000) novel models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even well - studied model organisms.

With such a rapid acceleration in the production of mouse lines that could be used to study a wide variety of phenomena, it's possible that we'll learn much more from our favourite mammalian model organisms in the near future.

Last week at The Allied Genetics Conference (TAGC), National Institutes of Health (NIH) Director Francis Collins provided an overview of model organism support from his agency.

She added, «New model systems will be a magnet for people from outside the field of marine microbial ecology as they will suddenly be able to work with marine microbes in ways that they are used to working with other model organisms.»

BioEmergences proposes collaborative services for the reconstruction of multilevel dynamics from the in vivo observation of developing model organisms.

In a new study, published in Current Biology this week, a research team from Uppsala University reports new insights into the regenerative capabilities of Stentor, a single celled model organism for regeneration biology.

Pol III was inhibited using a variety of genetic techniques across several different model organisms, from flies and worms to yeast.

A full realisation of the medical potential of stem cells for human health will likely depend on a reinforcement of, and development of a whole continuum of studies ranging from those in vivo using model organisms, to cell - based therapies in the clinic.

You no longer have to use a genome from another organism as your model.

Reagents: antibodies, plasmids, cell lines, RNA libraries, and more Organisms and viruses: model organisms of disease, mouse models, and more Biological specimens Software Protocols Core laboratories eagle - i is different from traditional web publications that list resources (websites, journals, etc.) because the tool allows researchers to: Share Organisms and viruses: model organisms of disease, mouse models, and more Biological specimens Software Protocols Core laboratories eagle - i is different from traditional web publications that list resources (websites, journals, etc.) because the tool allows researchers to: Share organisms of disease, mouse models, and more Biological specimens Software Protocols Core laboratories eagle - i is different from traditional web publications that list resources (websites, journals, etc.) because the tool allows researchers to: Share resources

Biological Annotation of the Genomic Sequence A key use of the sequence information from the canonical model organisms, such as Drosophila, will be to help interpret the sequence of the human genome.

To facilitate the search, I utilize discoveries and insights from various fields, including evolution, functional genomics, natural (dog) and artificial (mouse) model organisms as well as cell models.

We will mine and exploit information from studies and screens in model organisms, but our primary focus is on the paradigmatic mammalian stem cell systems - haematopoiesis and epithelia in vivo, and embryonic and neural stem cells in vitro.

Now we are embarked on experiments that will show improvements in both healthspan and lifespan in model organisms from mice to primates.

These tools will help to better understand ongoing changes in chemical and biological state of the North Sea from alkalinity fluxes originating from the Wadden Sea over a synthesis model that integrates OA sensitivities at organism level into a North Sea ecosystem model (5.1) to an economical impact assessment.

From widening the scope of model organisms to uncovering the inner workings of cells, for molecular biologists the human genome sequence has untold potential as a final frontier for exploratory science.

This will require bringing together the functional experts (molecular biology, model organisms, and reverse genetics) with the «gene hunters» as well as a serious commitment from funding agencies.

Findings We present a read dataset from whole - genome shotgun sequencing of the model organism Escherichia coli K - 12 substr.

The study «illustrates how full genomic information from a model species can help provide considerable insight into the genomic structure» of a distantly related and little - studied organism, the researchers write in Genome Research.

Model organisms are beloved by researchers investigating developmental biology, the progression of an organism from a fertilised egg into an adult.