Sentences with phrase «from normal mice in»

Untreated 3xTg mice displayed impaired learning and memory as expected, but 3xTg mice that were administered PD146176 for 3 months were indistinguishable from normal mice in a memory test.

Not exact matches

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

The mice were allowed at least 2 weeks for recovery from the implant procedure in order to return to normal function.

Three groups of middle - aged mice (about a year old) were studied: one group ate a normal diet, in which fewer than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.

To our amazement, the clearance was unchanged from that in normal mice.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplIn experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplin cancer stem cells that prompt leukaemic blood cells to multiply.

When the Stanford team measured pyrophosphate levels in cultured cells derived from ank and normal mice, they found that the chemical accumulated in cells from the ank mice but decreased in the culture medium.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

In another experiment, the research team transferred infection - combatting white blood cells — called neutrophils — from normal mice to genetically mutated mice.

During her postdoctoral work, Bissell noticed that removing mammary cells from a mouse and putting them into a culture dish caused them to lose not only their normal in vivo shapes, but also their ability to secrete milk.

Dr. Baran Sumer (left) and Dr. Jinming Gao (right) and have invented a transistor - like threshold sensor that can illuminate cancer tissue, helping surgeons more accurately distinguish cancerous from normal tissue in mouse models.

The purple GM tomatoes have already been found to prolong the lives of cancer - prone mice and in the latest findings they also more double the normal shelf life of tomatoes from an average of 21 days to 48 days.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythIn an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythin adult mice and restore a normal rhythm.

In the latest study, the researchers injected the nine miRNAs into zygotes from normal mice, implanted the zygotes in females, and allowed them to maturIn the latest study, the researchers injected the nine miRNAs into zygotes from normal mice, implanted the zygotes in females, and allowed them to maturin females, and allowed them to mature.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

In July, he and researchers from the University of Hawaii published evidence that apparently normal mouse clones can possess fundamental defects.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micIn the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal micin osteoblasts from normal mice.

Mice generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.

Kipnis and his colleagues wondered how smart mice would be if they had a normal supply of T cells everywhere in their bodies except the meninges, so he injected a compound into mice that prevented T cells from reaching the meninges.

This time, Xu used a sophisticated technique called droplet digital PCR to count the ribosomal DNA copies in normal and cancer cells from the mice.

DNA sequencing of sperm from the grandfather mice and their pups also revealed epigenetic marks on the gene encoding M71 that weren't seen in normal mice.

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

The quest for better opioids got a much - needed jolt in 1999, when researchers at Duke University showed that mice lacking a protein called beta - arrestin 2 got more pain relief from morphine than normal mice did.

The scientists found that transgenic mice in which phospholipase Cγ1 was unlinked from the TrkB receptor were less susceptible to seizures than normal mice.

Abraham Kierszenbaum of the City University of New York Medical School has conducted experiments in mice showing that even normal - looking sperm from a mutant mouse «is likely to create infertile offspring.»

Bacterial counts from rodents» poop showed that although B. fragilis did not establish lasting colonies in the mice, they did «shake up the community,» of microorganisms, bringing it closer to that of the normal mice, Hsiao says.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

Last year, as a first step in defining a «normal» lab mouse microbiome, they analyzed feces from mice from two major vendors.

Tom Bebee PhD, a postdoc in the Carstens lab and Rohacek compared RNA sequences from the cochleae of normal versus Esrp1 knockout mice.

To test the theory, he and his colleagues analyzed bacteria in fecal samples from lab mice kept in normal 12 - hour cycles of light and darkness.

When bacteria from these «clockless» mice were transplanted into healthy animals living in normal light - dark conditions, the microbes began to show normal rhythms within a week.

This decrease in circulating miRNAs could be restored when the investigators transplanted normal fat into these mice, a result indicating that many of the microRNAs in circulation were coming from fat.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

Raised in a germ - free environment, and then given a transplant of gut microbes from a four - day - old normal mouse, these mouse were still able to resist Salmonella infection without any help from their immune system — but only when they had received a dose of added Clostridium first.

They found that the samples from the older normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk.

But when the researchers added bacteria from 16 - day - old normal mice, the amount of C. rodentium in the guts of surviving mice went down.

The researchers compared mice with a normal glymphatic system to those with a disabled gene that prevented glial cells from assisting in the fluid flow.

The green - labelled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red.

Many of the metabolic changes in the mice prone both to obesity and diabetes could be duplicated by transferring gut microbes from mice treated with antibiotics to mice lacking normal gut microbes.

They observed a significant decrease in the number of proliferating stem cells in the brains of HIV / gp120 - mice compared with similar tissue from normal, wild - type mice.

Organoids enabled the team to compare normal pancreatic ductal cells in six mice with cells from the same animals in three distinct stages: premalignant, malignant, and metastatic.

Now, they have investigated gene expression in low - grade dysplastic lesions and normal stomach tissue from mice and in gastric cancer and normal stomach tissue from humans.

Constructs lacking the RP sequence were barred from the mitochondria, and even constructs with appended RP were reduced to ~ 13 - 17 % of normal import into mitochondria from mice with a liver - specific, two - thirds reduction in levels of the murine PNPase homolog.

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

The present study employed Ighb scid mice reconstituted with normal lymphocytes from young (2 -3-mo-old) and aged (20 -25-mo-old) donors and immunized with a protein conjugate of the hapten (4 - hydroxy -3-nitrophenyl) acetyl (NP) to determine whether the molecular changes in antibody repertoire reflect senescence in the B cells or whether they are mediated by the aging helper T lymphocytes.

Because the SD of brain progranulin in wild - type mice was about 10 % of the mean level, progranulin levels in Grn + / − mice would need to increase from 50 % of normal to 80 % of normal, i.e. by 30 % of the normal value, to reach the lower limit of normal.

SAN FRANCISCO, CA — A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer's disease, improving cognition to normal levels in aged mice.