Sentences with phrase «from normal mice of»

With no natural gut bacteria of their own, the mice offered a unique chance to see the effects of transplanted microbes from normal mice of different ages, and to test vulnerability to infection.

Not exact matches

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Three groups of middle - aged mice (about a year old) were studied: one group ate a normal diet, in which fewer than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.

The scientists exposed a group of mouse lemurs to moderate chronic caloric restriction (30 % fewer calories than their peers consuming a normal diet) from the outset of early adulthood (Restrikal cohort, see visuals below).

That's because the boosted mice produced normal — rather than high — levels of the amyloid precursor proteins from which plaques are made.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

Her team took purified extracts of the miRNA from stressed mice and injected them into normal embryos.

The normal mice's brain plaques seemed to be built from human A-beta protein, and the only source of that was the blood of the mutated partner mouse.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

A new study has determined that mice that spent time running on wheels not only developed twice the normal number of new neurons, but also showed an increased ability to distinguish new objects from familiar objects.

The purple GM tomatoes have already been found to prolong the lives of cancer - prone mice and in the latest findings they also more double the normal shelf life of tomatoes from an average of 21 days to 48 days.

In an independent effort, they introduced progressively smaller pieces of DNA from the large region known to contain the gene into embryos of the mutant mice, looking for the smallest piece that would correct the mutation in adult mice and restore a normal rhythm.

Song says the amyloid - beta traveled from the genetically - modified mice to the brains of their normal partners, where it accumulated and began to inflict damage.

As a final test to see whether parasites could directly access the brain from the blood, the researchers infected mice with a mixture of normal parasites and mutants that was unable to reproduce, each labeled in different colors.

In July, he and researchers from the University of Hawaii published evidence that apparently normal mouse clones can possess fundamental defects.

In the next experiment, Karsenty looked for evidence of such signaling effects in osteoblasts from normal mice.

(Left) Blood smears from anemic mice indicate irregular shapes of red blood cells; (right) wild type mice indicate normal shapes of red blood cells.

By transferring part of the gut bacteria from healthy mice to diabetic mice, they are re-establishing a normal level of cathelicidin.

On the flip side, said Tran, PGC1 alpha transgenic mice, which had increased expression of these genes, were particularly resistant to various stressors and recovered from injury much more than quickly than animals with normal regenerative abilities.

Ward's lab team took skin tissue samples from her well - established psoriasis transgenic mouse model, called the KC - Tie2 mouse, and compared it to skin tissue samples of normal mice.

Kipnis and his colleagues wondered how smart mice would be if they had a normal supply of T cells everywhere in their bodies except the meninges, so he injected a compound into mice that prevented T cells from reaching the meninges.

DNA sequencing of sperm from the grandfather mice and their pups also revealed epigenetic marks on the gene encoding M71 that weren't seen in normal mice.

For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.

Abraham Kierszenbaum of the City University of New York Medical School has conducted experiments in mice showing that even normal - looking sperm from a mutant mouse «is likely to create infertile offspring.»

Bacterial counts from rodents» poop showed that although B. fragilis did not establish lasting colonies in the mice, they did «shake up the community,» of microorganisms, bringing it closer to that of the normal mice, Hsiao says.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

Tom Bebee PhD, a postdoc in the Carstens lab and Rohacek compared RNA sequences from the cochleae of normal versus Esrp1 knockout mice.

To test the theory, he and his colleagues analyzed bacteria in fecal samples from lab mice kept in normal 12 - hour cycles of light and darkness.

This decrease in circulating miRNAs could be restored when the investigators transplanted normal fat into these mice, a result indicating that many of the microRNAs in circulation were coming from fat.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

Mice engineered to lack REG3G and fed alcohol for eight weeks were more susceptible to bacterial migration from the gut to the liver than normal mice who received the same amount of alcoMice engineered to lack REG3G and fed alcohol for eight weeks were more susceptible to bacterial migration from the gut to the liver than normal mice who received the same amount of alcomice who received the same amount of alcohol.

Raised in a germ - free environment, and then given a transplant of gut microbes from a four - day - old normal mouse, these mouse were still able to resist Salmonella infection without any help from their immune system — but only when they had received a dose of added Clostridium first.

They found that the samples from the older normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk.

But when the researchers added bacteria from 16 - day - old normal mice, the amount of C. rodentium in the guts of surviving mice went down.

Left: The gut of a mouse that received a transplant of microbes from the gut of four - day - old normal mice, and then was exposed to Salmonella, while the other received a transplant of the four - day - old mouse microbes along with added Clostridia bacteria, before being exposed to Salmonella.

The green - labelled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red.

Nunez, Kim, Sakamoto and their colleagues carried out a careful series of experiments using both newborn and adult germ - free mice, and samples of gut microbes taken from the feces of 4 - day - old, 12 - day - old and 16 - day - old normal mice.

Many of the metabolic changes in the mice prone both to obesity and diabetes could be duplicated by transferring gut microbes from mice treated with antibiotics to mice lacking normal gut microbes.

They observed a significant decrease in the number of proliferating stem cells in the brains of HIV / gp120 - mice compared with similar tissue from normal, wild - type mice.

Mice that received normal levels of prenatal vitamin A, from a regular diet, were born with more fat - loading white fat cells, fewer brown fat cells and fewer blood vessels.

Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV - specific CTL response of spleen cells from normal adult mice.

from mprize.org «Dwarf mice... lack growth hormone (GH), prolactin (PRL), and thyroid - stimulating hormone (TSH), (and) live much longer than their normal siblings, and exhibit many symptoms of delayed aging.»

Representative photomicrographs of lung tissue from unvaccinated unchallenged mice (normal) and from Balb / c mice two days after challenge with SARS - CoV that had previously been given PBS only (no vaccine) or live virus.

Constructs lacking the RP sequence were barred from the mitochondria, and even constructs with appended RP were reduced to ~ 13 - 17 % of normal import into mitochondria from mice with a liver - specific, two - thirds reduction in levels of the murine PNPase homolog.

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

Thus, mutation of mouse Boule disrupts male reproduction but does not affect normal development, growth or female fertility, suggesting that mammalian Boule is required only for male reproduction, similar to fly boule but different from worm daz - 1.

The resulting mice had normal populations of T regulatory cells from the thymus, but significantly diminished numbers of pTregs.