The scientists suggest that flavivirus helicases could have evolved a conserved motor to convert chemical energy
from nucleoside triphosphate to mechanical energy to unwind their genetic material, but the motors of the flaviviruses move in distinct ways to access their genomic RNA.
The Zika virus helicase is a motor enzyme that converts energy
from nucleoside triphosphate to unwind and separate double - stranded nucleic acids, so the single - stranded genetic material can then be copied.
Not exact matches
Under a High Court ruling, GOSH is forbidden
from allowing Charlie to be transferred for
nucleoside therapy anywhere.
Currently available drugs to treat HSV - 1 infection work by preventing the virus
from producing the proteins it needs to replicate and are known as
nucleoside analogs.
Initially operating in «stealth mode» — without announcement of its existence — Moderna's team screened mRNA assembled
from various modified
nucleosides and hit on one called 1 - methylpseudouridine.
Medications with antiviral or anti-HIV activities (ara - A, Vidarabin; ara - C, Alexan) are based on arabino -
nucleosides, which Bergmann isolated
from the Caribbean sponge Cryptotethya crypta in 1950.
The dose is in a form that protects the
nucleosides from breaking down in the gut.
Currently his lab is collaborating with biologists at Emory University to protect mitochondria
from toxic
nucleoside reverse transcriptase inhibitors.