Sentences with phrase «from obese mice»

In a later step of this study, microbiota from obese mice fed with a western diet were transferred to the microbiota - free mice.

Additionally, fecal transplant of gut microbes from obese mice to GF mice results in greater adiposity in the GF recipients than fecal transplants from lean donors (2).

mouse studies, macrophages taken from obese mice were less receptive to insulin than normal (in other words insulin resistant to a degree).

Transplanting gut flora from obese mice into lean mice turned the formerly lean mice fatter... Compelling evidence that gut flora has an important connection to body fat levels.

When the Cornell team cultured human breast cancer cells on matrix deposited by fat - derived cells from obese mice, the cancer cells grew faster than they did on the matrix of cells from slimmer mice.

«The nondigestible compounds in the Granny Smith apples actually changed the proportions of fecal bacteria from obese mice to be similar to that of lean mice,» Noratto said.

Two weeks after the transfer, recipient mice had lost considerable weight; another group that received microbes from obese mice in a placebo group — undergoing surgery without gastric bypass — stayed the same.

(source) The mice who received the microbes from the obese mouse gained more weight, despite comparable food intake and intake levels.

Not exact matches

The mouse stayed lean, even when they later added some bacteria from the obese twin.

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

In another animal microbiome experiment, Jeffrey Gordon, a biologist at Washington University in St. Louis, took a suite of microbes from the guts of both obese and lean mice and transplanted them into the guts of microbe - free mice.

«When given to obese mouse mothers during pregnancy and lactation, we found it protected their offspring from developing symptoms of liver fat and damage that leads to NAFLD in early adulthood.»

Protective antibodies from lean mice also failed to protect obese mice from flu infections.

The drug, SRT1720, kept mice with high - calorie diets from becoming obese or diabetic, according to a study published in Cell Metabolism [subscription required].

«Vaccines fail to protect obese mice from severe influenza infections: Fu vaccines with adjuvants don't work as well in obese mice.»

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

Probing the link between adiponectin deficiency and metabolic disorders like diabetes and obesity, researchers from the Albert Einstein College of Medicine in New York City injected adiponectin into wild - type mice, diabetic mice, and obese diabetic mice.

In one recent test, mice implanted with fecal microbes from thin humans stayed thin, while mice given bacteria from obese people gained weight.

Remarkably, the same healing effect was produced when B cells from older obese diabetic mice were applied to acute wounds in similarly aged, obese diabetic mice.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

Moreover, obese - phenotype mice were invaded by members of the Bacteroidales from the lean mice, but, happily, the lean animals resisted invasion by the obese microbiota.

«If human offspring from obese mothers have a similar risk for developing fibrosis as we see in mice, we may be able to predict who is going to develop more serious disease,» said Thompson.

The genetically obese and diabetic mice showed similar metabolic benefits from both WBV and exercising on the treadmill.

The study shows that a hormone acting on the placenta can protect the offspring of obese mice from being born overweight.

The researchers used electron microscopy and other imaging techniques to view thousands of cells from the liver tissue of lean and obese mice.

Based on the observation that obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.

MICROBE DIET Mice fed microbes from obese people tend to gain fat.

Gut bacteria from thin people can invade the intestines of mice carrying microbes from obese people.

To identify genes whose expression correlated with adiposity, we profiled gene expression in perigonadal adipose tissue from 24 mice in which adiposity varied due to sex, diet, and the obesity - related mutations agouti (Ay) and obese (Lepob).

Normally, germ - free mice exposed to a mouse with microbial - based obesity would themselves become obese, but we could design a microbial community taken from lean people that protected against this weight gain.

We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean mice and humans to over 50 % in extremely obese, leptin - deficient mice and nearly 40 % in obese humans.

Perigonadal adipose tissue was collected from obese B6.V Lepob / ob female mice and digested with a combination of collagenase I and collagenase II.

«We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage - mediated inflammation in obese mice,» said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine.

For example, we showed in collaborative work with Jeffrey I. Gordon's laboratory at Washington University in St. Louis last year that transferring the microbes from an obese person into mice raised in a bubble with no microbes of their own resulted in fatter mice.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

In fact, metabolic benefits were almost the same for genetically obese and diabetic mice from both WBV and those exercising on the treadmill.

Pini M, Rhodes DH, Castellanos KJ, Cabay RJ, Grady EF, Fantuzzi G. Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice.

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

In one study, researchers took microbiome samples from both lean and obese mice and placed them in the gut of neutral mice.

Aside from studies on obese mice, limited research has also shown reduced blood pressure, increased fat burning and increased fatty acid oxidation later in the fast, and increased metabolic rate due to the release of epinephrine and norepinephrine (again, later in the fasting period).

It was shown that the mice with the obese microbiome sample actually extracted MORE calories from the same exact food, gained more weight, and had increased insulin resistance.

In 1994, it was discovered that a protein hormone called leptin, which is released from fat cells and monitored by the brain, was deficient in a certain strain of genetically mutated obese mice.

Aids in weight loss Microbe - free mice injected with bacteria from obese people gained weight while mice injected with bacteria from thin people did not.

When bacteria from thin people was injected into the obese mice, they lost weight.

Researchers at Washu took identical twins where one was lean and other was obese, same genetic material transplanted the microbes into germ - free mice, and lo and behold, the mouse who received the microbes from the obese twin gained weight without any change in diet.

What's more exciting is mice studies show that transplanting bacteria from thin humans into obese mice causes the obese mice to lose weight.

In mice studies, mice that received bacteria from an obese person became obese.

To explore whether this was a cause of obesity or the effect of it, another research team gave mice the bacteria from sets of twins where one was obese and the other was lean.