Sentences with phrase «from olaparib»
The results are extremely encouraging, suggesting that men with prostate cancers that contain defective DNA repair genes may benefit from olaparib treatment.»
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«The results from this innovative clinical trial are very promising and highlight the potential for olaparib — and other PARP inhibitors — to treat a wide range of cancers.
Of the 16 patients with detectable DNA repair mutations, 14 responded to olaparib — accounting for the large majority of patients who benefited from the drug.
Hence, a total of 90 patients from nine centers were randomly assigned to one of two study arms for the phase II clinical trial: the first taking capsules of olaparib (400 mg twice daily) and the other taking a combination of the two drugs (200 mg olaparib in capsule - form twice daily and 30 mg tablets of cediranib once daily).
Men with prostate cancer benefit from treatment with the pioneering drug olaparib — the first cancer drug to target inherited mutations — according to the results of a major trial.
They are also looking for «biological signposts» to predict which cancers are most likely to respond to olaparib, which will help doctors identify men who are likely to benefit from the new treatment.
An international research team, led by University College London's Professor Jonathan Ledermann, carried out a trial to see whether olaparib could have a role to play in preventing ovarian cancer from coming back in this group of patients.
Olaparib was also detected in 27 of 28 tumour margin specimens from 10 patients (mean concentration 500nM).
Treating women with olaparib, a new type of experimental drug called a PARP inhibitor, after their initial cancer treatment, may help prevent their ovarian cancer from coming back, according to a phase - II clinical trial led by UK scientists.
Olaparib is a PARP inhibitor, which is already used to treat certain ovarian cancer patients and prevents damaged cancer cells from repairing themselves after chemotherapy or radiotherapy.
** Olaparib was detected in 73 of 74 tumour core specimens from 27 patients (mean concentration: 588nM).
B, CT scans from patient 2 pre-olaparib, on treatment, and after resistance show a liver metastasis at 17 mm on February 8, 2016, decreased to 6 mm on June 16, 2016, after olaparib treatment began, and at 18 mm on September 13, 2016, respectively.