Not exact matches
The study published in Cancer Cell shows that exosomes
from tumor cells of breast cancer (and other
tumor types such as
ovarian and endometrial) are different in size and composition than those of healthy cells.
P: We found discodermolide [a drug
from Discodermia, a sponge found in the Caribbean, the Bahamas, and the Gulf of Mexico], and it's gone through phase I clinical trials for treatment of solid
tumors such as
ovarian, pancreatic, breast, colon, or lung cancers.
New research
from George Vasmatzis, Ph.D., of the Department of Laboratory Medicine and Pathology at Mayo Clinic, finds liquid biopsies
from blood tests and DNA sequencing can detect a return of
ovarian cancer long before a
tumor reappears.
A section of a
tumor organoid grown
from cells derived
from a patient with high - grade serous
ovarian cancer (left) and a mini-
tumor treated with ReACp53, resulting in extensive cancer cell death.
In some cases such as
ovarian cancer, however, drug - free intervals are needed to allow patient recovery
from side effects, during which
tumors can sometimes begin to grow again or develop resistance to the drugs being used.
In their research, scientists at Rutgers created animal models that closely resemble the cancerous
tumors found in women with
ovarian cancer by injecting
tumor tissues obtained
from gynecological cancer patients treated at the Cancer Institute into laboratory mice.
The team collected
tumors from 68 women affected with
ovarian and uterine CSs to try to determine the molecular basis of the
tumor's aggressive behavior.
VIC - 008 is a fusion protein combining an immune - activating protein
from the tuberculosis bacteria with a small antibody fragment targeting mesothelin, a protein expressed in several types of
tumor — including mesothelioma, pancreatic and
ovarian cancer.
Notably, the researchers found that, using their methods, highly reactive TILs could be obtained
from some 90 % of the
ovarian cancer patients whose
tumor samples they examined.
[4] Sabbatini P, Tsuji T, Ferran L, Ritter E, Sedrak C, Tuballes K, Jungbluth AA, Ritter G, Aghajanian C, Bell - McGuinn K, Hensley ML, Konner J, Tew W, Spriggs DR, Hoffman EW, Venhaus R, Pan L, Salazar AM, Diefenbach CM, Old LJ, Gnjatic S. Phase I trial of overlapping long peptides
from a
tumor self - antigen and poly - ICLC shows rapid induction of integrated immune response in
ovarian cancer patients.
The earliest and one of the most striking came
from observations that the presence of infiltrating T cells (called «
tumor - infiltrating lymphocytes,» or TILs) in
ovarian tumors is positively and strongly associated with improved survival of patients with
ovarian cancer [1].
Their theory was first confirmed with
ovarian cancer cell lines and then the Peter / Lengyel team tested HGMA2 protein levels in
tumor samples
from 100 patients with
ovarian cancer.
Surveillance of the
tumor mutanome by T cells during progression
from primary to recurrent
ovarian cancer.
These interests grew
from studies of paraneoplastic neurologic disorders (PNDs), a group of diseases thought to arise when
tumors — typically breast,
ovarian, or lung cancers — start making proteins normally only made by the brain.
iPSC - NKs themselves have already shown efficacy in the battle against leukemia and HIV infection [4, 5] and so researchers
from the laboratory of Dan S. Kaufman (University of Minnesota, USA) aimed to assess their anti-tumorigenic capabilities against
ovarian tumors [6].
The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such
tumors as mesothelioma,
ovarian cancer and pancreatic cancer — to a protein
from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.
Given the well - established role of steroid hormones in breast cancer etiology for postmenopausal women, these findings may have important health implications»
Tumor growth
from these hormone imbalances is also evident «A dramatic increase in estrogen - dependent malignant diseases, such as
ovarian, corpus uteri, breast, testicular and prostate cancers has been recognized.
I recently had an emergency oophorectomy due to
ovarian torsion
from multiple cysts and a
tumor on my left ovary.