Results of an initial study of tumors
from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.
In a test designed to show how the tool would be used in actual practice, Dr. Wang retrospectively tested iCAGES using detailed sequencing data
from a patient with lung cancer.
Not exact matches
Led by associate professor of pathology and Yale
Cancer Center member Don Nguyen, PhD, the researchers analyzed RNA
from patients with disease that was limited to the
lungs as well as
cancers that had spread.
The researchers combined data
from lung cancer patients in The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD)
with claims data
from the Centers for Medicare & Medicaid Services (CMS).
Researchers only discovered this process in the late 1990s, but they've already begun dozens of clinical trials to gauge whether infusing
patients with these small RNAs works against a range of diseases,
from lung infections to liver
cancer to age - related macular degeneration, a sight - stealing condition that mainly affects people over the age of 50.
A drug approved by the Food and Drug Administration (FDA) for melanoma in combination
with a common cholesterol - lowering drug may show promise in controlling
cancer growth in
patients with non-small cell
lung cancer (NSCLC), according to new research
from the Icahn School of Medicine at Mount Sinai.
«FDG PET shows tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived
from FDG PET could improve treatment selection for
patients with advanced non-small cell
lung cancer.»
Nana - Sinkam and his colleagues examined
lung - tumor samples
from 81
patients with stage - 1 nonsmall - cell
lung cancer and tumor - cell lines.
Patients with epidermal growth factor receptor (EGFR) expressing advanced squamous non-small-cell
lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerl
lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switze
cancer benefit most
from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis
from the SQUIRE trial presented today at the European
Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerl
Lung Cancer Conference (ELCC) 2016 in Geneva, Switze
Cancer Conference (ELCC) 2016 in Geneva, Switzerland.
Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA)
from the plasma of advanced non-small cell
lung cancer (NSCLC)
patients correlates well
with the EGFR mutations
from patient - matched tumor tissue DNA.
Research
from McMaster University has identified new regulators of brain metastases in
patients with lung cancer.
The study used samples
from lung cancer patients with brain metastases.
The researchers found there was a decline in the relative proportion of
patients with lung cancer meeting the USPSTF criteria overall,
from 57 percent in 1984 - 1990 to 43 percent in 2005 - 2011.
The authors found that most
lung cancer patients (regardless of stage) want physical activity advice directly
from a physician at a
cancer center before
cancer treatment and exercise guidance may increase compliance
with a dedicated program.
In a letter published in the
cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected
lung cancer patient with the
cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away
from attack by anti-retroviral therapy.
Perera began working
with Weinstein on a small study comparing two groups of hospital
patients: One group was suffering
from lung cancer; the other was a group of orthopedic
patients as a control sample.
The researchers prospectively collected blood and tissue samples
from 161
patients with metastatic breast
cancer, non-small-cell
lung cancer (NSCLC), or castration - resistant prostate
cancer.
An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement
with results
from a phase I trial showing that, among 236
patients with various types of
cancer, the treatment shrank tumors in 28 percent of melanoma
patients, 30 percent of
patients with kidney
cancer, and 18 percent of
patients with advanced non-small cell
lung cancer.
In the new study published in JAMA Oncology on June 4, Saad Khan,
from the University of Texas Southwestern Medical Center, and colleagues said that a chunk of
lung cancer patients with autoimmune disease are not eligible to receive the latest immunotherapy treatments.
Researchers have found that treating
patients who have early stage non-small cell
lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated
with a small but increased risk of death
from causes other than
cancer.
In this study, the new computer program and two other methods (called Random Forest and Support Vector Machine) were tested
with blood samples
from 29 liver
cancer patients, 12
lung cancer patients and 5 breast
cancer patients.
Of the
patients undergoing SABR, 419 (58.7 %) died during follow - up,
with 119 (16.7 %) dying
from lung cancer; and 680 (30.1 %)
patients undergoing video assisted thoracoscopic resection died during follow - up,
with 198 (8.8 %) dying
from lung cancer.
DNA Detectives Find Genetic Markers for
Lung Cancers Most Likely to Recur Researchers at the Johns Hopkins Kimmel Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early - stage lung cancers that look like good predictors of which of these cancers are more likely to re
Lung Cancers Most Likely to Recur Researchers at the Johns Hopkins Kimmel Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed from patients with early - stage lung cancers that look like good predictors of which of these cancers are more likely to
Cancers Most Likely to Recur Researchers at the Johns Hopkins Kimmel
Cancer Center uncovered clearly recognizable genetic alterations in tumors and tissue removed
from patients with early - stage
lung cancers that look like good predictors of which of these cancers are more likely to re
lung cancers that look like good predictors of which of these cancers are more likely to
cancers that look like good predictors of which of these
cancers are more likely to
cancers are more likely to recur.
Researchers tested the effects of CBD, THC, and an endocannabinoid analogue called methanandamide on two
lung cancer cell lines, A549 and H460, along
with cells
from a
lung cancer patient.