Sentences with phrase «from preclinical»

There is now ample evidence from the preclinical and clinical fields that early life trauma has both dramatic and long - lasting effects on neurobiological systems and functions that are involved in different forms of psychopathology as well as on health in general.

Until then, we can only continue to extrapolate from preclinical data, and bring up many of the issues discussed above.

In his role as IDRI's Chief Medical Officer, Corey is developing and leading all clinical trial programs for IDRI from preclinical to Phase III, including oversight and management of data functions.

SMA researchers then presented results from preclinical models that suggest SMA is a whole - body disease.

The meeting focused on evidence from preclinical models and patients that indicate SMN has a role outside of the CNS and the implications of these data for systemic treatment of SMA.

«So far, there has been a poor track record of moving things from preclinical discoveries into successful clinical trials,» says senior author Steve Finkbeiner, MD, PhD, a senior investigator at the Gladstone Institute of Neurological Disease and a professor of neurology and physiology at UCSF.

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson.

Cell therapy has been studied for multiple degenerative disorders and promising results from preclinical studies and clinical trials have been described for some.

Scientists and vaccine developers involved in EVI projects presented project progress and research findings, highlighting one of the most important areas of EVI's activities; translation of research on diseases of poverty vaccines, focusing on early stages from preclinical to clinical development through harmonisation.

Published new efficacy and safety data from preclinical studies of AST - OPC1 in the peer - reviewed journal «Stem Cells Translational Medicine.»

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

The meeting focused on evidence from preclinical models and patients that indicate SMN has a role outside of the CNS -LSB-...]

Since eye and vision research can be conducted noninvasively, advancement of trials from the preclinical to the clinical phase could be relatively fast.

«Evidence from preclinical research had previously indicated a relationship between solid tumors, immune response, and the microbiome.

Together, these findings indicate that microglia - mediated brain inflammation may demarcate the transition from preclinical Alzheimer's disease to full dementia.

In his current role, he combines population research and functional genomics strategies to inform drug development from preclinical through phase 3 trials.

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson, Professor at the Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

Not exact matches

«[A.I.] can help analyze large data sets from sources such as clinical trials, health records, genetic profiles, and preclinical studies; within this data, it can recognize patterns and trends and develop hypotheses at a much faster rate than researchers alone,» says Deloitte.

In those areas that we have mapped, it typically takes us a few hours to go from a mechanism - inspired idea for treating a disease to knowing the companies that might have relevant clinical and preclinical assets to license, the companies from whom a candidate could be commissioned, trial designs and endpoints, competing and complementary agents, current and future standard of care, market size, comparable pricing, financing strategy, and potential acquirers, all meant to enable a thoughtful first - pass assessment of whether an idea could be worth a much deeper assessment.

Through a rigorous pharmaceutical approach, Gnosis carries out a seamless flow of operations, from product concept to research and development, preclinical and clinical studies, regulatory filing and Intellectual properties, manufacturing and distribution standing alongside customers.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Preclinical findings revealed that Myb gives immune cells called regulatory T (Treg) cells the «authority» to control the strength of the immune response depending on the level of «threat», from minor infections to aggressive diseases.

For example, Matt Krause, director of human resources at CV Therapeutics, says, «Our research programs include multiple, cutting - edge cardiovascular product candidates in various stages of clinical trials and preclinical programs, all of which rely heavily on the contributions from our many B.S. - and M.S. - level scientists.»

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

«She had worked at Immunex's law department, was one of the co-discoverers of Enbrel and was listed on multiple original Immunex patents, and had been involved in preclinical work on compound discovery,» says Ruth Kunath, who managed Vulcan's biotech portfolio from 1992 to 2003 and hired Beckmann.

Now, a new preclinical study from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never - before - seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib.

Jones has recruited scientists from many different backgrounds, including chemical development, clinical R&D, preclinical / toxicology, and information management.

Study leader Robert Darnell, a Howard Hughes Medical Institute (HHMI) investigator at the Rockefeller University, calls the findings «an exciting step toward a different kind of treatment approach,» but cautions that the results, from studies of mice, are preclinical.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

Their findings confirm preclinical evidence that the agent, which is derived from salmonella flagellin, is worthy of further investigation as treatment for some of the most common and most resilient solid - tumor cancers.

The research into quantum dots containing single magnetic ions was funded with grants from the Polish National Science Centre and the Polish National Centre for Research and Development, as well as project funds from the Centre for Preclinical Research and Technology.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Formerly a research leader at CHOP, High pursued groundbreaking preclinical investigations in hemophilia B gene therapy and provided scientific expertise to previous gene therapy trials in hemophilia and other genetic disorders at CHOP before moving to Spark Therapeutics, which was spun off from CHOP in 2013.

Study results showed that in preclinical models tumor - to - background ratios obtained from 11C - sarcosine PET were significantly elevated compared to 11C - choline.

An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1.

Preclinical studies have shown TDI - 132 can decrease the number of immune cells, keeping cells in lymph nodes from entering general circulation.

The collaborators identified 50 high - impact preclinical cancer papers published from 2010 to 2012, began writing protocols to replicate key experiments, and published the plans in eLife.

A Houston Methodist team led by Mauro Ferrari, PhD and Jenny Chang, MD has received funding from the U.S. Department of Defense to complete preclinical efficacy studies and a future clinical trial testing a breast cancer precision drug.

Because of a lack of standardised and harmonised preclinical studies, there is limited information we can so far obtain from literature on the relative predictive value of different animal models and alternative methods for vaccine evaluation.

And there are a lot of treatments, or let's say potential treatments, that are working wonderfully in preclinical models that are ready to make the leap to human testing, and some of these have begun to make that transition to bridge from the laboratory to human - patient testing.

These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.

Nanotheraputics for Antibiotic Resistent Emerging Bacterial pathogens (NAREB) European Research Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.

To obtain an integrated measure of long - term, preclinical 25 - hydroxyvitamin D level for each individual, we calculated the average of these adjusted 25 - hydroxyvitamin D levels from all the available samples, except for those collected after the onset of MS among cases.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

She graduated from Trinity with honors in chemistry and participated in a summer internship in Pharmacology and Preclinical Development at Tularik Inc. (currently Amgen) in South San Francisco.

Over the course of its development, PNP has secured grants from the National Institutes of Health of approximately $ 10 million to support preclinical research at Southern Research Institute and UAB.