Sentences with phrase «from preclinical studies»

Cell therapy has been studied for multiple degenerative disorders and promising results from preclinical studies and clinical trials have been described for some.

Published new efficacy and safety data from preclinical studies of AST - OPC1 in the peer - reviewed journal «Stem Cells Translational Medicine.»

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

Not exact matches

«[A.I.] can help analyze large data sets from sources such as clinical trials, health records, genetic profiles, and preclinical studies; within this data, it can recognize patterns and trends and develop hypotheses at a much faster rate than researchers alone,» says Deloitte.

Through a rigorous pharmaceutical approach, Gnosis carries out a seamless flow of operations, from product concept to research and development, preclinical and clinical studies, regulatory filing and Intellectual properties, manufacturing and distribution standing alongside customers.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Now, a new preclinical study from Penn Medicine researchers found that in many cases the root of the resistance may lie in a never - before - seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib.

Study leader Robert Darnell, a Howard Hughes Medical Institute (HHMI) investigator at the Rockefeller University, calls the findings «an exciting step toward a different kind of treatment approach,» but cautions that the results, from studies of mice, are preclinical.

Now, a preclinical study, from the lab of Olivier Berton, PhD, an assistant professor in the department of Psychiatry, in collaboration with Sheryl Beck, PhD, a professor in the department of Anesthesiology at Children's Hospital of Philadelphia, found that bullying and other social stresses triggered symptoms of depression in mice by activating GABA neurons, in a never - before - seen direct relationship between social stimuli and this neural circuitry.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Study results showed that in preclinical models tumor - to - background ratios obtained from 11C - sarcosine PET were significantly elevated compared to 11C - choline.

An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1.

Preclinical studies have shown TDI - 132 can decrease the number of immune cells, keeping cells in lymph nodes from entering general circulation.

A Houston Methodist team led by Mauro Ferrari, PhD and Jenny Chang, MD has received funding from the U.S. Department of Defense to complete preclinical efficacy studies and a future clinical trial testing a breast cancer precision drug.

Because of a lack of standardised and harmonised preclinical studies, there is limited information we can so far obtain from literature on the relative predictive value of different animal models and alternative methods for vaccine evaluation.

The Wake Forest Institute of Regenerative Medicine (WFIRM) has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclinical findings all the way through Phase 2 clinical trials.

Together with the research and clinical resources of the nation's leading cancer hospital, we have the ability to take a program from a research hypothesis all the way to a clinical candidate supported by robust preclinical data, and into early phase clinical studies in well - defined patient populations.

Recent approval from the U.S. Food and Drug Administration to begin clinical studies was based on compelling activity upon IACS - 10759 treatment in multiple preclinical models of AML.

This study is a beautiful example of multidisciplinary team science at partnering academic institutions advancing a life - saving therapeutic from the laboratory, to preclinical studies, deftly though complex regulatory pathway, to the clinic and — with final FDA approval — hopefully into the marketplace.

Previous studies from the laboratory of Daniel B. F. Saris (University Medical Center Utrecht, The Netherlands) reported that a novel stem cell combination represented a safe and efficient means to repair cartilage in preclinical [1] and early clinical studies [2].

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

Ward et al. highlight results from molecular and preclinical studies, discuss clinical trial results to date, describe ongoing investigations, and assess novel approaches for the enhancement of MSC based cardiac regeneration, such as genetic modification.

In this study, we clinically tested a therapeutic platform that we have previously described in preclinical studies [12] in which B cells from NHL dogs are expanded in vitro using CD40L transfected K562 cells (KtCD40L) and then loaded with autologous tumor RNA to generate a cell - based vaccine.