The average progression - free survival — the time
from randomization to the first evidence of metastasis — was 40.5 months for participants receiving apalutamide, compared with 16.2 months for those taking a placebo.
Median follow - up time
from randomization for the entire patient population was 4.2 years, and findings reflect the 866 patients who reached two - year follow - up at the time of reporting in May 2016.
There were no differences between groups in the gestational age at randomization, time to uterine quiescence, time on study drug, length of hospitalization, days
from randomization to delivery, incidence of side effects, or admissions to the neonatal intensive care unit.
Not exact matches
The study used Mendelian
Randomization (MR) techniques to examine publicly available data
from genome - wide association studies.
Reporting for
randomization, for instance, tripled between 1992 and 2011,
from 14 % to 42 %; reporting for blinded assessment and conflicts of interest also rose sharply.
They offer many best practices lessons and how - to guides on a variety of topics,
from research design and
randomization, measurement and data collection, to working with data.
Nearly all of the patients resuscitated
from VF and admitted to the hospital received hospital cooling regardless of their
randomization.
With a median follow - up of 36.7 months, the researchers found no survival benefit of chemoradiotherapy compared with chemotherapy, with median overall survival
from the date of the first
randomization of 15.2 months and 16.5 months, respectively.
Primary outcome comparisons are presented as hazard ratios (HRs) and 95 % confidence intervals (CIs)
from Cox proportional hazards analyses, 17 stratified by clinical center, age, prior disease, and
randomization status in the low - fat diet trial.
The overall survival
from the point of
randomization was 13.9 months, compared with 11 months in the placebo group.
Recurrence - free survival
from the time of
randomization to the date of the first local or distant recurrence of melanoma or death due to any cause is the primary endpoint.
37/3: 00 Mendelian
randomization provides evidence for a causal effect of low vitamin D on multiple sclerosis risk: Results
from the Kaiser Permanente MS Research Program.
Design, setting, and participants: Mendelian
randomization analyses evaluating the association between CETP and HMGCR scores, changes in lipid and lipoprotein levels, and the risk of cardiovascular events involving 102837 participants
from 14 cohort or case - control studies conducted in North America or the United Kingdom between 1948 and 2012.
To look at the issue, Paul Elliott, FRCP, of Imperial College London, used a technique called Mendelian
randomization, which is based on the arbitrary assignment of genes
from parent to child — a bit like assigning someone either a placebo or a real drug.
Schools with first - year principals and those slated for closure in the spring of 2009 were excluded
from the sample prior to
randomization.
Randomization could easily produce two lotteried - in students who just happen to be quite different
from the 18 lotteried - out students.
For the
randomization, researchers in 2009 - 10 generated estimates of teachers» performance based on composite measures using data
from the surveys, prior test scores, and observation scores.
Roguelikes descend
from the 1980 game Rogue, particularly mirroring Rogue «s character - or sprite - based graphics, turn - based gameplay that gives the player the time to plan each move, permanent death and
randomization.
With multiple endings and an extensive
randomization system that will ensure that every playthrough will always be different
from the previous one, whether you as a player succeeded in escaping or not.
Screening / enrollment staff were masked to
randomization status and sequence and were different
from assessment staff.
Randomization group assignments were concealed
from the research assistants who performed the enrollment.
For
randomization sites for a dichotomous outcome and control - group prevalences ranging
from 0.2 to 0.8, we found greater than 90 % power to detect a treatment effect odds ratio (OR) of 1.5.
The evidence for VIG's effectiveness came (first)
from a series of small qualitative and quantitative studies of VIG without controls or
randomization.
Limitations include small sample size, retrospective recall may have been compromised, and unable to differentiate condition
from therapist effects, may not generalize to other racial / ethnic groups or to the broader population of depressed adolescents with comorbid conduct disorder and other psychiatric disorders, and
randomization process resulted in unequal gender representation in the two conditions.
Limitations include lack of
randomization of participants, lack of long - term follow - up and attrition of parents
from the posttest period.
The quality of each study was evaluated independently by MS and SJM according to the following eight validity criteria, which were adapted
from the Consolidated Standards of Reporting Trials (CONSORT) guidelines [14,15] and Delphi criteria list [16]:
randomization; allocation concealment; blinding of outcome assessments; comparability of groups at baseline; withdrawals; handling of dropouts in analyses; use of intention - to - treat analysis; and multiple follow - up assessments.
The research administrator then randomizes the family by adding the name to the
randomization list in the order the names arrive
from the interviewer.