When an opioid binds to a receptor in the peripheral nervous system, the nerve cells outside the brain, the receptor changes shape and sets in motion a cellular game of telephone that stops pain
messages from reaching the brain.
Scientists at the US Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR) recently developed a vaccine that blocks the opioids in
heroin from reaching the brain in mice and rats, offering a potential breakthrough in treating opioid addiction.
This type of inflammation causes a condition known as «leaky brain» which occurs when there is damage to the blood - brain barrier (the filter that prevents toxic
substances from reaching the brain).
When he hit his head on the ice, the sudden movement of his brain inside his skull could have crushed or even cut them against the bone, preventing signals from his
nose from reaching his brain.
The capsaicin works to relieve pain by reducing the amount of the pain - triggering chemical called substance
P. from reaching the brain.
Folate intake is also associated with a decreased risk of depression and other mood disorders by inhibiting an overload of homocysteine in the body, which can hinder essential
nutrients from reaching the brain.
Their findings, published in Neurosurgery, lend hope to patients around the world with neurological conditions that are difficult to treat due to a barrier mechanism that prevents approximately 98 percent of
drugs from reaching the brain and central nervous system.
Their study, published in the Journal of Medicinal Chemistry, found that this new vaccine was not only effective in preventing
heroin from reaching the brain but worked with other commonly abused opioids as well, including hydrocodone, oxycodone, hydromorphone, oxymorphone, and codeine.
«If they could figure out a way to streamline, it would be a lot better,» said Kim Janda, a professor of chemistry at the Scripps Research Institute in La Jolla, California, who leads a team of researchers developing a vaccine that would prevent fentanyl overdoses by keeping the drug
from reaching the brain.
Used medicinally, these toxins block pain signals
from reaching the brain, yielding pain relievers more powerful than morphine.
Grasshopper mice have a mutation in protein Nav1.8 that prevents this signal
from reaching the brain.
11 A lean, muscular person will be less affected by drink than someone with more body fat: Water - rich muscle tissues absorb alcohol effectively, preventing
it from reaching the brain.
These include patches, gum and other nicotine - releasing products designed to replace cigarettes, as well as drugs that sequester nicotine in the body to prevent
it from reaching the brain, where its addictiveness takes hold.
Hitting opioid receptors in the peripheral nervous system keeps pain messages
from reaching the brain.
The vaccine, administered by way of a carrier protein, trains the body to produce antibodies that intersect and neutralize heroin, preventing
it from reaching the brain and having an effect.
Alcohol is a depressant, so it slows the function of the central nervous system actually blocking a number of the messages
from reaching the brain.
Does malabsorption of the small intestine prohibit vital substances (like serotonin...)
from reaching the brain?