Now, early results
from sequencing projects of the enterohemorrhagic Escherichia coli (EHEC) strain appear to confirm that a never - before - seen hybrid, combining the worst of several bacterial strains, is causing the havoc.
Not exact matches
The 3,000 Rice Genomes
Project (3K RGP) is a collaborative, international research program that has
sequenced 3,024 rice varieties
from 89 countries.
So even though some of the leaders of the 2014 avian tree effort launched B10K, a
project aiming to eventually
sequence the whole genomes of all 10,560 bird species and
from there build «the grand tree,» some bird researchers decided not to wait.
Faircloth hopes his team will not use any of the samples used in the B10K
project, as having DNA
sequence from multiple individuals of the same species can be useful.
When the team looked for it in data
from the Human Microbiome
Project, a large - scale project to sequence the DNA of all the microbes that live in and on our bodies, they found that it was present in 73 per cent of all 466 faecal s
Project, a large - scale
project to sequence the DNA of all the microbes that live in and on our bodies, they found that it was present in 73 per cent of all 466 faecal s
project to
sequence the DNA of all the microbes that live in and on our bodies, they found that it was present in 73 per cent of all 466 faecal samples.
Project members also catalogued
sequences that mark areas where DNA unwinds
from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.
The human (and all the other) genome
projects were predicated on the reasonable assumption that spelling out the full
sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm
from fly, mouse, chimp and human.
Along the way, the hope is that the
project will transform the technology of neuroscience — in the same way that the Human Genome Project (HGP) helped take genome - sequencing from pipe dream to everyday reality — and ultimately revolutionise our understanding of brain fu
project will transform the technology of neuroscience — in the same way that the Human Genome
Project (HGP) helped take genome - sequencing from pipe dream to everyday reality — and ultimately revolutionise our understanding of brain fu
Project (HGP) helped take genome -
sequencing from pipe dream to everyday reality — and ultimately revolutionise our understanding of brain function.
Wellcome Trust managers and
sequencing researchers
from the Sanger Centre endorsed the publicly funded genome
project's approach at a meeting this week.
Project leader Dr Richard Buggs
from QMUL's School of Biological and Chemical Sciences said: «This ash tree genome
sequence lays the foundations for accelerated breeding of ash trees with resistance to ash dieback.
When the researchers expanded their search to include all the data
from the Human Microbiome
Project, a large - scale project to sequence the DNA of all the microbes that live in and on our bodies, they found that the same virus was present in 73 per cent of all 466 human faecal s
Project, a large - scale
project to sequence the DNA of all the microbes that live in and on our bodies, they found that the same virus was present in 73 per cent of all 466 human faecal s
project to
sequence the DNA of all the microbes that live in and on our bodies, they found that the same virus was present in 73 per cent of all 466 human faecal samples.
Results
from the
Sequencing the Legends
project are still being processed but indicate that the Bos taurus genes lurking in the Brahman genome may have been selected for important production traits associated with fertility, growth and temperament.
For one such
project, the team developed a new software tool called GppFst that allows researchers to differentiate genetic drift — a neutral process whereby genes and gene
sequences naturally change due to random mating within a population —
from genetic variations that are indicative of evolutionary changes caused by natural selection.
Darwin's declared strategy was to capture the
sequence information streaming
from the genome
project and apply it to the development of new drugs.
The goals of these hard - core
sequencing projects range
from studying climate change, to classifying — or even resurrecting — extinct species, to improving cancer diagnosis.
So, there is now over 800 flu
sequences that have emerged
from that
project in just the last year and I expect that number to more than double in the next year.
Bioinformatics tries to solve biological problems by using computers to make sense of the large amounts of data that arise
from sequencing and other large - scale
projects.
In addition to taking on the T. rex
project, Asara also succeeded in wresting 76 collagen
sequences from a slightly younger find — mastodon bone fragments with soft tissue estimated to be 160,000 to 600,000 years old.
Proposals for the
project have come
from John Sulston, who heads a prestigious Anglo - American
project to
sequence the genome of the nematode Caenorhabditis elegans at the MRC's Laboratory of Molecular Biology in Cambridge.
But researchers report today that they've figured out how to predict the structures of hundreds of unmapped proteins by gleaning insights
from one of the strangest of places: «metagenomics»
projects that
sequence DNA
from broad swaths of microbes in the soils and seas.
Soon, the mouse — which
from a genetic point of view is nearly human — will join this ship: its genome is sought in another race between the publicly funded mouse genome
sequencing project and Celera.
Yet, «these studies using HeLa cells had to rely on information
from the «reference»
sequence produced by the Human Genome
Project, even though there was evidence that the genomes of HeLa cell lines were probably quite different,» said Lars Steinmetz, Ph.D., who led the G3 study.
The study, led by Dr Chris Tyler - Smith of the Wellcome Trust Sanger Institute, analysed
sequence differences between the Y chromosomes of more than 1200 men
from 26 populations around the world using data generated by the 1000 Genomes
Project.
«Tim and I were able to work very closely in all the steps of the
project from the experimental design in the wet lab to the final analysis of the results; the major challenge was how to handle the very large number of barley samples and for this we designed a novel approach to
sequencing that exploited deep results in combinatorics,» Lonardi said.
As a step toward boosting rice production to meet a
projected 25 % increase in demand by 2030, researchers
from three Asian institutions today announced the release of the genetic
sequences of 3000 rice lines.
«As that genome
sequence was
from a female, the findings of the bovine Y chromosome study is a significant contribution to the completion of the bovine — male and female — genome
project.»
The Human Microbiome
Project, funded by the US National Institutes of Health, has now used next - generation DNA
sequencing technology to study these microbes straight
from the source.
Xuanmin Guang,
project manager
from BGI, said, «Minke whale is the first marine mammal that has been
sequenced with such high - depth genome coverage.
That money, most of it
from federal grants through the Human Genome
Project, has paid for the first rough guides to the 3 billion nucleotides in human DNA: maps studded with thousands of landmarks called «
sequence tagged sites» (Science, 25 October 1996, p. 540).
Alexis Borisy, CEO of Foundation Medicine, a cancer diagnostics company in Cambridge, Massachusetts, that studies how genetics can be translated into therapies, says that the study is «an excellent example of a coming wave of information
from cancer genomes» that he expects to be
sequenced in the future through the Cancer Genome Atlas and other
projects.
Related Sites Science article on the discovery of the Mimivirus Science article on the Mimivirus
sequence Science news article on the evolutionary origins of the nucleus Primer on Genome
Sequencing from the Human Genome
Project
The newest study
from the Autism Speaks MSSNG
project — the world's largest autism genome
sequencing program — identified an additional 18 gene variations that appear to increase the risk of autism.
Then they checked blood samples against half a million known variations in DNA
sequences, or single - nucleotide polymorphisms, which recently were identified by the International HapMap
Project that looked for differences in the genomes of people
from many populations.
His team is now trying to get some idea by collecting information and different strains via existing global and European Union research
projects that compile genetic
sequences from pathogens.
With crowdfunded
projects such as American Gut, which already has thousands of participants who have had their microbiomes
sequenced, and studies of people whose lives are very different
from modern Western civilization, such as the Hadza of Tanzania, Yanomami of Venezuela and Matsés of Peru, we may be able to replenish our ancestral microbes and discover new ones that help to maintain health for individuals or entire populations.
Other medical
sequencing projects will use DNA
sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases;
sequence all of the genes on the X chromosome
from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.
For instance, the Human Microbiome
Project (HMP)(Turnbaugh et al, 2007; Peterson et al, 2009; Huttenhower et al, 2012) and MetaHIT (Qin et al, 2010) have generated maps of bacterial species abundances throughout the human body, reference genomes, and catalogs of more than 100 million microbial genes assembled
from shotgun
sequencing of in vivo communities.
Holly Tabor et al analyzed de-identified exome data
from 6,517 individuals obtained
from NHLBI's Exome
Sequencing Project (ESP).
The large volume of
sequence data
from novel organisms generated by metagenomic
projects has triggered the development of specialized databases and tools focused on particular groups of organisms or data types.
The goals of the
project are as follows: (1) to shotgun
sequence the C. murisgenome to 8X coverage; (2) to
sequence 20,000 clones
from a C. muris cDNA library to provide gene prediction training and verification data; and (3) to manually annotate the C. muris genome
sequence in comparison with the genome
sequence data for C. parvum and C. hominis.
My first post in 2015 was uncannily prescient: it reviewed a study that uncover rare variants associated with myocardial infarction using exome data
from NHLBI's Exome
Sequencing Project (ESP).
A research
project launched today will blend the muscle of a huge Chinese genome
sequencing center with the funding prowess and ambition of a high - profile American advocacy group, to create the world's largest library of
sequenced genomes
from people with autism.
The scientists used data
from the UK10K
Project — a massive, whole ‐ genome
sequence ‐ based resource of the general European population; the NIH - funded 1000 Genomes
Project, one of the world's earliest efforts to
sequence the genomes of a large number of people; and data
from several other studies.
By conducting an RNA -
sequencing experiment of 103 matched tumour and normal colon mucosa samples
from Danish CRC patients, 90 of which were germline - genotyped, researchers
from the collaborative European
project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).
Here, we describe the results obtained
from our current long read
sequencing project of 100 Icelanders with Oxford Nanopore technology.
This science
project was adapted from the East Bay Biotechnology Education Program's High School Chloroplast Sequencing Project: Panico, E., Rosenbaum, S., and Shellem, B.
project was adapted
from the East Bay Biotechnology Education Program's High School Chloroplast
Sequencing Project: Panico, E., Rosenbaum, S., and Shellem, B.
Project: Panico, E., Rosenbaum, S., and Shellem, B. (n.d.).
In the first phase of the
project, SIGMA scientists
sequenced and characterized more than 10,000 tissue samples
from Mexican and Mexican Americans.
If you use
sequence data
from any of the other Pseudomonas genome
sequences, please acknowledge the appropriate genome
project and genome
sequence publication
«These
projects span an impressive spectrum of novel technologies -
from sequencing by synthesis to nanopore technology.
NIH - NIAID has funded this genome
project to
sequence nine phenotypically characterized strains of B. pseudomallei, as well as 25 B. pseudomalleibacteriophage genomes isolated
from 48 different B. pseudomallei strains
from various geographic and clinical sources.