Sentences with phrase «from small molecule drugs»

Alternatively, once the down stream targets of Rett's silencing effect have been determined, phamra companies have several tools in their arsenal to treat the disease, from small molecule drugs to RNAi.

Not exact matches

The pH during one of the reactions was a bit too low, causing the drug to extrude a single small molecule of propionic acid, which transformed it from a powerful narcotic into a poison that laid waste to the brain's dopamine receptors.

Unpublished results from the researchers hint that significantly fewer anomalies are seen in iPS cells created via virus - free reprogramming strategies, such as ones that use proteins or small - molecule drugs.

However, this security system is so effective at protecting the brain that it prevents many life - saving drugs — all but some small molecules — from being able to treat cancer and other diseases of the brain.

The researchers behind the new study, from Winston - Salem State University in the US and Universiti Malaysia Sarawak in Malaysia, have found that adding similar, but smaller polycationic molecules onto a new kind of material called carbon nanodots makes them even better at killing drug - resistant bacteria.

Scientists already have a drug that can curb Brd4's actions — a small molecule called JQ1 that prevents Brd4 from binding to chromatin.

The new drug, a small molecule called anle138b, blocks these pores from moving ions in and out of nerve cells.

In the early 2000s, Danishefsky — who is best known for synthesizing Taxol (paclitaxel), a small - molecule cancer drug derived from the Pacific yew tree — set his sights on synthesizing EPO that would be identical to that in the body.

A typical small - molecule drug derives its activity from such functional groups, which are bound to a relatively simple backbone structure consisting chiefly of carbon atoms.

One effective approach is to deliver drugs made from small molecules of ribonucleic acid, or RNA, which are used to inhibit gene expression.

They collected gene expression data from six genetically diverse breast cancer cell lines, which were each exposed to 109 small - molecule drugs at multiple dosages and time points.

The consolidation of these efforts in an independent initiative will allow faculty from the CMI to lead a focused investigation in small molecule drug discovery for multiple therapeutic applications.

(That's different from manufacturing a small - molecule generic, which will have the exact chemical structure of the brand - name drug.)

Lipitor and Plavix are small - molecule drugs, a class of treatment that includes everything from aspirin to many of today's most sophisticated drugs.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

«We have provided evidence, in collaboration with Erich Wanker from Berlin, that such activation can be achieved, in principle, with an experimental small molecule drug [called] geldanamycin.

Scientists can screen collections of small organic molecules — the type of molecules needed for pill - based drugs — to find any that compete with the peptides by binding tightly to Gα proteins and preventing them from transmitting signals.

Figure 2: Comparing the patent landscapes for induced pluripotent stem cell (top) and a small - molecule drug candidate (MK - 1775, bottom) highlights need for intellectual property consideration in cell therapy DST — search and analysis conducted in Thomson Innovation and Thomson Data Analyzer (TDA) software from Thomson Reuters; themescape maps produced using TDA.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

The targets can vary from things that are very small, like a drug molecule to something much larger, like bacteria or viruses.

Its pharmaceutical products include chemically - synthesized drugs or small molecules and an increasing portion of products produced from biological processes called biologics.

These large molecule drugs differ from traditional pharmaceuticals in that they are usually injected, while small molecule pharmaceuticals are taken in tablet form.