Sentences with phrase «from targeted therapy»
This collaboration could help to devise tests to identify patients who will benefit from these targeted therapies.
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Triple - negative breast cancers do not benefit from the targeted therapies that have greatly improved the survival of patients with other subtypes of breast cancer.
Not exact matches
But for all of the attention paid to its cancer drug pipeline, Bristol just scored a breakthrough therapy designation from the Food and Drug Administration for a treatment that targets hepatitis C.
Groups is very simple: For $ 65 a week, it offers group therapy in areas plagued by opioid addiction — targeting towns with fewer than 10,000 residents and little access to recovery programs — so people at different stages of recovery can learn from one another.
«Data and insight that comes directly from patient records — real - world evidence — is transforming how pharmaceutical and life science companies develop more precise, targeted therapies,» said Cota CEO John Hervey in a statement.
The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.
That therapy for treating melanoma is already in the development pipeline, along with 906 other biologics targeting over 100 diseases from autoimmune disorders to viruses.
The primary aim is to investigate the use of targeted therapy using antibodies and antibody - conjugates and remove toxic chemotherapy and radiation from the treatment to maintain high cure rates and decrease late effects.
To achieve this goal, the cancer field is moving away from chemotherapy and towards a combination of immunotherapy and targeted therapy, an approach that is more potent and less toxic.
Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.
Prof. Severine Vermeire (KU Leuven / UZ Leuven): «In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota - based therapies, such as fecal microbiota transplantation or targeted pre - and probiotics.»
However, not everyone's melanoma will benefit equally from MAPK - targeted therapies, and initial benefits might wane over time as tumors develop resistance to treatment.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.
«Previous bacterial infection increases risk of newly - diagnosed Sjögren's syndrome: Identifying trigger will hopefully help future development of targeted therapy for patients suffering from this debilitating disease.»
«Enzyme keeps antibodies from targeting DNA, driving inflammation in lupus: Study may open door to future biologic therapies.»
«It has applications from understanding many growth regulatory pathways and for understanding critical processes that should lead to the identification of the targets needed for the development of new therapies.
The researchers believe there are other disease entities, aside from cancers, that may be significantly affected by targeted epigenetic therapies.
Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.
To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.
Dwarki and Jaime Escobedo improved the AAV's ability to insert genes into chromosomes by adding a gene promoter region from cytomegalovirus, known to be active in the target for their gene therapy, muscle cells.
According to the researchers these findings may suggest additional targets for medical therapy to minimize morbidity and mortality from this potentially devastating cancer.
«More evidence for impact of lung cancer targeted therapy from practice - changing trial.»
«Now that we've identified where the replication - competent virus is hiding, we can start work towards targeting these cells with new therapies aimed at fully eliminating HIV from the body,» Associate Professor Palmer concluded.
The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»
New research from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai identifies a protein that may be an unexplored target to develop new cancer therapies.
Dr. Jones obtained his Ph.D. in 2003 from the University of Birmingham Institute of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young, studying the use of gene therapy for targeting Epstein - Barr Virus (EBV) proteins with replication - competent adenoviruses to treat EBV - driven malignancies.
«Therapies that increase the brain's flexibility at switching from rest to goal - directed behaviors may be a good target, for instance.»
As part of a second trial, Swanton's lab will also study what happens to tumors under the selective pressure of various types of cancer therapies, from traditional chemotherapy to targeted drugs.
«This hampers integration of lipidomics into systems biology, and addressing it will improve our fundamental understanding of lipid biology, help identify new drug targets for therapy and discover lipid biomarkers from disease cohorts.»
Over the past two decades, the field has started to move from chemotherapy and radiation to targeted monoclonal antibodies and, now, to therapies that activate a patient's own immune system to fight cancer.
Results from 599 patients receiving combination targeted therapy of dabrafenib (BRAF inhibitor) and trametinib (MEK inhibitor) were:
This work allows us to hone in on those patients who don't do as well, and who would most benefit from more targeted therapies,» Dr. Radisky says.
Because RNA carries the genetic message from DNA to the cell's proteinmaking factories, or can directly perform acts such as gene regulation, it, too, is an appealing target for therapies.
Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.
The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.
Another reason to prioritize the systematic study of proteins in tumors — cancer proteomics — is that the vast majority of cancer therapies developed from genetic studies actually target proteins.
Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.
Their latest pledge came after Druker recently lobbied the couple for another $ 1 billion to take insights from Gleevec, as well as other so - called molecularly targeted therapies, and develop better early detection tools for tumors.
Research from Rutgers Cancer Institute of New Jersey examining gynecologic cancers that poorly respond to therapy shows genomic profiling can help identify alternate and targeted treatments.
Though smaller in number, some patients with advanced disease and carrying a BRCA mutation may benefit from the same targeted therapy being used today in the clinic to successfully treat some ovarian cancer patients.»
Such rapid and extensive degradation suggests that conjugates may be able to prevent or hinder cancer cells from developing resistance to targeted therapies, the researchers state.
The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»
The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study.
Using patient tissues obtained directly from operating rooms, the researchers found that the cells began to adapt to and resist therapies that target the growth pathway called mTOR in as little as 48 hours.
Takahashi predicts that in the future, selecting from different stem cell therapies will «depend on the target disease and the situation of the host.»
«Longer term, our hope is that we will be able to develop therapies that target this process, such as drugs that would be able to limit an infection and prevent it from spreading from the initial site of attack.
Dr George Vassiliou, joint project leader from the Sanger Institute and Consultant Haematologist at Cambridge University Hospitals NHS Trust, said: «This research has led to the identification of many potential gene targets for future AML therapy, which we are making available to other researchers to explore.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Other blood disorders that have shown significant benefit from targeted gene therapy in small trials include hemophilia (specifically, factor IX deficiency), severe beta - thalassemia (deficiency for the adult beta - globin gene) and leukemia, where the patient's immune cells were treated to enable them to recognize cancer cells and destroy them.
The authors noted: «From this perspective, by strengthening tumor - associated immune responses, targeting [regulatory T cell] autophagy could act in synergy with strategies that block autophagy in tumor cells for added benefits in cancer therapy.»