Sentences with phrase «from tumor sites»

The chip would allow the filtering of cancer cells from a blood sample, which would be an easier way to harvest cancer cells, rather than the current method of taking them from tumor sites in the body.

The team of medical and engineering researchers at The Ohio State University previously determined that modifying a single gene to reduce this protein's level in breast cancer cells lowered the cells» ability to migrate away from the tumor site.

When the protein is present, these cells that start out round and stuck together in a pattern resembling cobblestones become irregularly shaped and tend to detach from the tumor site in an uncoordinated way — hallmarks of metastasis.

Each tumor site was represented by four cores from different areas of the specimen; two cores from each tumor site were included in each of two TMA blocks (8 cores of each patient in total).

Not exact matches

Since the neurosurgeon said the brain tumor is not currently life threatening, I am not having surgery to remove it this year, but the back and forth and all the doctor's visits and catching up with work has kept me from having the time to do much on this site.

«Gradual release of immunotherapy at site of tumor surgery prevents tumors from returning.»

The bone fragment, which comes from the famous archaeological cave site of Krapina, contains by far the earliest bone tumor ever identified in the archaeological record.

Research from past studies found that most tumor cells remain in the primary breast site, but a subset of cells leaves the breast and enters the bloodstream.

With a grant from the Morris Animal Foundation, Antczak, his collaborators Samantha Brooks and Ann Staiger from the University of Florida, and the rest of the team applied a genomewide association study to compare the genetic makeup of horses with and without sarcoid tumors at more than 50,000 sites in the equine genome.

Comparing the metastasized tumors with the original breast tumors, the researchers were surprised to learn that multiple, slightly genetically different cells from the original site had broken away together and established the new tumors.

Biopsied tumor tissue from all 60 new patients was fixed in formalin and embedded in paraffin so that TMEM sites in the tissue could be counted.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

Bone metastases happen when cancer cells travel from the primary tumor site to the bone, establishing a new cancer location.

Anti-inflammatory cancer therapy instead would prevent premalignant cells from turning fully cancerous or would impede an existing tumor from spreading to distant sites in the body.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

Understanding how cancer cells are able to metastasize — migrate from the primary tumor to distant sites in the body — and developing therapies to inhibit this process are the focus of many laboratories around the country.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

Importantly, it's secretion from normal cells can be induced by activating p53 so that Par - 4 enters circulation, thereby potentially targeting tumor cells at distant sites.

The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast cancer patients — including both primary tumors that had not spread from the breast to other body sites, and highly aggressive, metastatic tumors.

Metastasis (the spread of cancer from its primary site to other places in the body) to the ovaries can result in Krukenberg tumors.

This allows cancer cells to break off from tumors, spread throughout the body (in blood or other fluid) and form new tumors at distant sites — a process called metastasis.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

It is not easy to determine whether metastasis began early or late in the development of the primary tumor or whether individual metastatic sites were seeded directly from the original tumor or from an intermediate site.

Even a syringe of one's own stem cells taken from one part of the body and squirted into another «may multiply, form tumors, or may leave the site you put them in and migrate somewhere else» the fda warns on its Web site.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

These results, published in Nature Communications, have the potential to improve current cancer immunotherapy strategies, especially in relation to the prevention of metastasis (dissemination of the tumor to organs distant from the site of origin).

The Ludwig Center at the University of Chicago --- under the direction of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair of the Department of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute at the University of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary tumor to multiple distant sites.

Furthermore, the genetic and expression profiles of malignant cells vary within individual tumors, between tumors at different sites within the same patient, and among tumors from different patients.

CXCR4 is a receptor that cancer cells use like antennae to feel their way from their parent tumor to distinct sites in the body where they will establish a new tumor.

One limitation of our study is the use of metastatic samples from various organ sites, potentially influencing expression via differences from the organ - specific tumor microenvironment.

While metastatic sites may have originated from the primary tumor, several studies have demonstrated a different immunohistochemical or mutation profile compared to the primary.

However, access to tumor from distant disease sites may be feasible, raising the question of which tissue to study, the primary which is resected or the distant sites which will need the benefit of systemic therapy.

Age, tumor size, tumor site, LNM, VI and HER2 / neu immunopositive stain as well as the immunostaining of ER and PR for the malignant group were obtained from the Pathology Department, MRI.

We're home to the University of Chicago Ludwig Center for Metastasis Research, a multidisciplinary center dedicated to the research and treatment of metastasis — the process by which cancer cells spread from a primary tumor to one or more distant sites.

Intensive local therapy was followed by up to a year of less intense systemic treatment with cis - retinoic acid (a derivative of vitamin A) and interferon in an effort to control any microscopic tumors that had spread to distant sites from the initial cancer.

Metastatic disease refers to cancer that has spread through the blood or lymph system to form new tumors in other parts of the body distinct from the original site.

Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.

We identified 134 mouse susceptibility genes from 129 common insertion sites within 34 mammary tumors.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

Identify an alternate paradigm of tumor progression whereby metastases arise from cells that disseminate from the primary site at any stage of primary tumor progression and evolve independent from the primary tumor (i.e., parallel progression models).

Tumor growth in different glands is usually multifocal, (meaning the tumors develop in many sites), rather than from spread or seeding of tumor cells from a single initial Tumor growth in different glands is usually multifocal, (meaning the tumors develop in many sites), rather than from spread or seeding of tumor cells from a single initial tumor cells from a single initial site.

We believe that disrupting this niche will delay or prevent metastatic spread, and more importantly, protect tumor sites from hemorrhage, which is the most common lethal event in this disease.

Other symptoms to look out for are clear, milky or bloody secretions coming from the nipples; open sores that don't heal; ulcerated or necrotic (dead) tissue at the site of the tumor; and weight loss for no reason.

The liver is one of the main sites in which metastases from tumors of other parts of the body grow.

Tuohy knew from experience that dogs with osteosarcoma often die even after the tumor is removed, as the cancer spreads to distant sites.

She had very little medical care during that time and so arrived in rescue with horrible dental problems, an infected former surgical site and several mammary tumors, not to mention the psychological problems from years of living in a wire cage.

In autograft the tumor site is removed from the leg and then treated with a high dose of radiation to «kill» the tumor.

A potential serious complication from vaccination is the development of an injection site sarcoma, a malignant tumor that can arise at any subcutaneous (under the skin) injection site.

Hematogenous metastatic brain tumors commonly originate from extracranial sites.

The lungs are also one of the main sites in which metastases from tumors of other parts of the body grow.