Sentences with phrase «from tumor suppression»

Title: Two sides of the Myc - induced DNA damage response: from tumor suppression to tumor maintenance Authors: Campaner S and Amati B Date: 2012 Publication Details: Cell Division 2012; 7 (1): 6

Not exact matches

In recent years, therapeutics aiming to restore the tumor suppression function of the immune system have shown impressive clinical results, but not all cancer patients benefit from these.

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

This suggests that treatment with IL - 15 can successfully relieve tumor - resident killer T cells from functional suppression and reactivate them to kill pancreatic cancer cells.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).