The prognostic role of a gene signature
from tumorigenic breast - cancer cells.
Not exact matches
In a collaborative study, researchers
from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and
tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.
We also found that cells derived
from this novel subpopulation form colonies readily, are highly
tumorigenic in immune - deficient mice, and exhibit both stem - like and EMT phenotypes.
Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this
tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate
from the epithelium and activate a JNK - dependent transcriptional response.
In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent
tumorigenic clones with constitutive STAT5 activation.14 This model was developed
from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).
Cancer stem cells (CSCs) known as
tumorigenic cells are biologically distinct
from diverse subpopulations.