Not exact matches
Lederman, who says he's «obsessed» with Jenner and has been working on a biography of the scientist for 20 years, is convinced that Jenner's original vaccine, now named
vaccinia, was derived
from a virus circulating in horses, not cows, as folklore has it.
He wonders whether it's not
vaccinia, the virus used to induce smallpox resistance, but some other component of the vaccine that's prompting inflammation, perhaps bovine cells
from the manufacturing process.
When the team tried to clone the heavy chain - only antibodies
from three llamas, they could not get a set that would bind well to the several biothreats they desired to test — among them ricin, cholera toxin and
vaccinia (a surrogate of smallpox virus).
That's what the
vaccinia virus seems to be saying after it invades a cell and prevents its companions
from following suit.
The proteins work together to form a complex on the cell's surface that prevents other
vaccinia virus particles
from entering (a process called superinfection).
When other
vaccinia viruses come knocking, long projections of another protein, actin, shoot out
from the cell membrane, causing the virus to bounce off.
They have taken extensive precautions to prevent the spread of
vaccinia to health care workers and other patients
from the moment he arrived.
On March 3, 2007, a two - year - old boy suffering
from severe eczema and an unusual, widespread rash was transferred
from St. Catherine's Hospital, in East Chicago, IN, to the University of Chicago's Comer Children's Hospital where he was diagnosed with eczema vaccinatum — a rare, severe, adverse reaction to the
vaccinia virus.
Raised in mice primed with a SIVmac251 gp160
vaccinia recombinant (vAbT253), and boosted with glutaraldehyde - fixed SIVmac11 / 88
from C8166 cells.