Compared to the frontal FC measure,
the frontal EEG activity measure had less statistical power in predicting children's behaviors at 24 months of age in our study.
Moreover, children of postnatally depressed mothers showed lower left
frontal EEG activity at age of 1 - to 3 - months [21], through to 6 [22] and 13 - to -15 months [19].
This study employed a large longitudinal normative Asian sample and investigated how pre - and early post-natal maternal depression as well as the change between them impacted infant
frontal EEG function at 6 and 18 months of age and behaviors at 24 months of age.
In this study, we first examined whether pre - and early post-natal maternal depressive symptoms independently associate with infants»
frontal EEG activity at 6 and 18 months of age, and internalizing and externalizing behaviors at 24 months of age using a large longitudinal normative Asian sample.
These studies have suggested that infants born to prenatally depressed mothers had greater right
frontal EEG asymmetry than those born to non-depressed mothers [10, 12].
When including prenatally and postnatally depressed mothers with middle and upper SES, Lusby et al. (2014) found no association between postnatal depressive symptoms and
the frontal EEG asymmetry at 3 - and 6 - month infants after adjusting for prenatal maternal depression [12].
Furthermore, a few longitudinal studies have examined the postnatal maternal depression trajectory in relation to children's
frontal EEG asymmetry and behaviors from 14 months to 6.5 years [20] and to children's social skill from 1 to 36 months [23].
First, we examined the relationships of plausible covariates, including gender, birth - weight, post-conceptual age on the visit day (gestational age + days of life since birth to the visit day), ethnicity, prenatal smoking exposure, and child sleep condition at the time of EEG recording with outcome measures (
frontal EEG power, functional connectivity at 6 and 18 months of age, or behavioral scores at 24 months of age).
However, our study did not reveal any significant associations of
the frontal EEG activity with internalizing and externalizing behaviors.
Although relative right
frontal EEG asymmetry was widely reported to reflect a vulnerability to maternal depression [3], our study found that neither pre - nor early post-natal maternal depressive symptoms independently contributed to the prediction of the right frontal activity, FC, nor their asymmetry in 6 - and 18 - month infants.
Beyond
frontal EEG activity, we examined the influence of prenatal and postnatal depression upon frontal functional connectivity (FC).
Neither prenatal nor postnatal maternal depressive symptoms independently predicted neither
the frontal EEG activity nor functional connectivity in 6 - and 18 - month infants.
Infant
frontal EEG asymmetry in relation with postnatal maternal depression and parenting behavior.
To examine our second aim, regression analyses were conducted to examine the associations of the fluctuation of maternal depression (postnatal — prenatal) with
frontal EEG at 6 and 18 months of age and children's internalizing and externalizing behaviors at 24 months of age.
Although pre and post-natal maternal depressive symptoms did not independently predict infant frontal function, our study demonstrated a prominent association of the change of maternal depressive symptoms from the prenatal to postnatal period with right
frontal EEG activity and relative right
frontal EEG asymmetry in 6 - month infants, that is, increasing maternal depressive symptoms from the prenatal to postnatal period predicted greater right frontal activity and relative right frontal asymmetry amongst 6 - month infants.
Behavioral activation sensitivity and resting
frontal eeg asymmetry: Covariation of putative indicators related to risk for mood disorders
Our study did not reveal any relationships between prenatal (or postnatal) maternal depression with
frontal EEG activity nor frontal connectivity of infants at 6 months and 18 months of age.
However, limited research has examined the effects of congruence and incongruence between prenatal and postnatal maternal depressive symptoms on
frontal EEG function and behaviors of children in the first 2 years of life.
Second, we examined whether the congruence or incongruence of maternal depressive symptoms between pregnancy and early postnatal period, represented by the change of levels of maternal depressive symptoms between pregnancy and postnatal period, influences
frontal EEG activity and functional connectivity, as well as internalizing and externalizing behaviors at 24 months of age.
In line with previous research on the disadvantage of the incongruence of prenatal and postnatal environments on early child development [25], we hypothesized that children whose mothers had elevated postnatal maternal depressive symptoms when compared to that during pregnancy may show greater atypical
frontal EEG activity and frontal functional connectivity and greater internalizing and externalizing behavioral problems.
To examine our first aim, separate regression models were used to evaluate
each frontal EEG measure (dependent variable; frontal EEG power: FL, FR, and FA; functional connectivity: FL, FR, and FA), and each behavioral score (dependent variable; internalizing and externalizing score) in relation with pre - or post-natal maternal EPDS score (independent variable).
Although many studies have examined the relationship between maternal depressive symptoms and
frontal EEG activity, less research has examined how the fluctuation of maternal depressive symptoms between pre - and early post-natal period is related to
frontal EEG activity.
For the third aim, regression analyses were conducted to examine the associations of
frontal EEG at 6 and 18 months of age (independent variable) with externalizing and internalizing behavioral scores at 24 months of age (dependent variable).
Positive affect is associated with greater degrees of left compared with right superior
frontal EEG activity at rest (18).
ADHD Symptoms in Post-Institutionalized Children Are Partially Mediated by Altered
Frontal EEG Asymmetry.
Not exact matches
The onset of meditation in the monks coincided with an increase in high - frequency
EEG electrical activity in the so - called gamma band (spanning 25 to 42 oscillations a second), which was synchronized across the
frontal and parietal cortices.
Those who woke during REM sleep and successfully recalled their dreams were more likely to demonstrate a pattern of
EEG oscillations called theta waves in
frontal and prefrontal cortex areas — the parts of the brain where our most advanced thinking occurs.
For example, certain biological events during early development, such as excessive androgen production, exposure to synthetic androgens, thyroid dysfunction, Cushing's disease, and congenital adrenal hyperplasia, can combine with environmental influences to predispose women to antisocial behavior.69 Additionally,
EEG research has uncovered asymmetries in the
frontal activation of antisocial females» brains.70 Normative males and females tend to exhibit asymmetric
frontal brain activation, with boys having greater right
frontal activation and girls having greater left
frontal activation.
Moreover, greater - postnatal - than - prenatal maternal depressive symptoms were associated with lower right
frontal FC in 18 month olds (β = -0.382, p = 0.002, df = 58), after adjusting for post-conceptual age on the
EEG visit day.
However, increasing maternal depressive symptoms from the prenatal to postnatal period predicted greater right
frontal activity and relative right
frontal asymmetry amongst 6 - month infants but these finding were not observed amongst 18 - month infants after adjusted for post-conceptual age on the
EEG visit day.
Subsequently increasing maternal depressive symptoms from the prenatal to postnatal period predicted lower right
frontal connectivity within 18 - month infants but not among 6 - month infants after controlling for post-conceptual age on the
EEG visit day.
In conclusion, our study utilized a large longitudinal Asian sample and provided the first evidence on progressive influences of the fluctuation of maternal depressive symptoms from pregnancy to early postnatal period, first on the
EEG activity of the
frontal region and then on its functional integration across the brain in the later stage.
This study investigated the relationships between pre - and early post-natal maternal depression and their changes with
frontal electroencephalogram (
EEG) activity and functional connectivity in 6 - and 18 - month olds, as well as externalizing and internalizing behaviors in 24 - month olds (n = 258).
After adjusting for post-conceptual age on the
EEG visit day and birth weight, neither the 6 - month
frontal activity nor
frontal FC predicted CBCL externalizing and internalizing scores of infants at 24 months of age (Table 3).
Although most of studies focused on either prenatal or postnatal maternal depression, they have reached a consensus, that is, that greater relative right
frontal electroencephalogram (
EEG) asymmetry has been suggested to be a neural basis reflecting a vulnerability of offspring to maternal depression [3, 7, 8].
After adjusting for post-conceptual age on the
EEG visit day, greater - postnatal - than - prenatal maternal depressive symptoms were significantly associated with greater right
frontal activity (Table 2, Fig 2b) and greater relative right
frontal asymmetry in infants at 6 months of age (Table 2, Fig 2c).
Briefly, in the female sample, greater - postnatal - than - prenatal maternal depressive symptoms were significantly associated with greater right
frontal activity (β = -0.262, p = 0.020, df = 72) and greater relative right
frontal asymmetry in infants at 6 months of age (β = -0.426, p < 0.001, df = 72) after adjusting for post-conceptual age on the
EEG visit day.
Adjusted for post-conceptual age on the
EEG visit day, regression analysis did not reveal an association of prenatal or postnatal EPDS with the bilateral
frontal activity and its asymmetry in 6 - month and 18 - month - old infants (Table 2).