Sentences with word «frontotemporal»

Both teams found that mutations to the same gene can also cause a common type of dementia called frontotemporal dementia (FTD).

Beyond PSP, other brain diseases are also marked by abnormal tau clumps — among them a rare movement disorder called corticobasal degeneration, an inherited form of frontotemporal dementia with Parkinson's - like features, and Alzheimer's disease.

Brain - imaging studies have shown that most patients with frontotemporal dementia who develop skills have abnormally low blood flow or low metabolic activity in their left temporal lobe.

Research led by Florida Atlantic University, in collaboration with the Association for Frontotemporal Degeneration and Emory University, is the first to capture the economic burden of FTD in the United States and the results are staggering.

Funding sources include the Consortium for Frontotemporal Dementia Research, the ALS Association, the National Institute of Neurological Disorders and Stroke, the National Center for Research Resources and the National Institutes of Health.

These immature cells were impaired at turning into mature, specialized cells called cortical neurons — the most affected cell type in frontotemporal dementia.

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update.

The cause of degeneration was unknown, although one patient who had died with a brain autopsy showed a type of brain degeneration known as frontotemporal lobar degeneration, Dr. Josephs says.

«We knew that the lack of progranulin caused frontotemporal dementia, and that it affects Alzheimer's disease, but we didn't know how,» said Li.

Reappearance may be attributed to certain neurological conditions including dementia (especially in a rare set of diseases called frontotemporal degenerations), traumatic lesions, and strokes.

Apathy: a neurocircuitry model based on frontotemporal dementia Ducharme S, Price BH, Dickerson BC.

But the five volunteers who improved were those whose frontotemporal areas had been successfully targeted, according to separate neurological assessments.

«iPSC models can now be used to better understand dementia, and in particular frontotemporal dementia, and might lead to the development of drugs that can curtail or slow down the degeneration of cortical neurons,» Verfaillie says.

Frontotemporal disorders are the result of damage to neurons in parts of the brain called the frontal and temporal lobes, gradually leading to behavioral symptoms or language and emotional disorders.

«They really do lose the linguistic meaning of things,» says Miller, who believes Snyder's ideas about latent abilities complement his own observations about frontotemporal dementia.

In 2015, Rothstein's team found out how a mutation in a gene — implicated in 40 percent of inherited ALS cases and 25 percent of inherited frontotemporal dementia cases — gums up transport in and out of the nucleus in neurons, ultimately shutting the cell down and leading to its death.

Patients can have a clinical presentation that is predominantly motor (ALS), predominantly frontotemporal (FTD), or a mixture of both (ALS - FTD).

Scientists from the Gladstone Institutes will team up with other national experts to better understand frontotemporal dementia.

Based on postmortem histopathology, a wide range of different non-AD conditions was identified, including frontotemporal dementia, hippocampal sclerosis, and dementia with Lewy bodies.

«This work could lead to major progress in our fight against frontotemporal dementia and other diseases involving tau that affect millions of people across the globe.»

58/4: 15 Neuronal aneuploidy and associated apoptosis in familial and sporadic frontotemporal lobar degeneration indicate that FTLD, like Alzheimer's disease and Niemann - Pick C1, is a cell cycle disorder.

Amyotroph Lateral Scler Frontotemporal Degener 2015 Jul 15:1 — 11

Thanks to an $ 11 million grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), Gan will lead a collaboration among national scientists to study how the protein tau affects neurons in the brain and how it causes disease, particularly frontotemporal dementia.

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, which leads to progressive muscle weakness and ultimately to lethal paralysis, while frontotemporal dementia (FTD), the second most common form of dementia (after Alzheimer's) in those under 65.

Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel - based morphometry study

Abstract: While behavioral symptoms are both early and prevalent features of behavioral variant frontotemporal dementia (bvFTD), they can be present in other types of dementia as well, including Alzheimer's disease (AD) and even mild cognitive impairment (MCI).

Mutations in a gene called progranulin (GRN) are commonly associated with frontotemporal dementia, but GRN mutations in mice do not mimic all the features of the human disorder, which has limited progress in the development of effective treatments.

The family of former Hudson Valley Congressman Maurice Hinchey announced today that the Democrat, 78, is suffering from a rare, terminal disorder known as Frontotemporal Degeneration.

ChengZhong Wang, PhD, Johanna Knoferle, MD, David Walker, Maureen Balestra, Leslie Tong, Laura Leung, PhD, Karen Ring, PhD, and Mihir Kshirsagar also participated in this research at Gladstone, which received support from the Tau Consortium, the California Institute for Regenerative Medicine, the National Institutes of Health, the Consortium for Frontotemporal Dementia Research, the S.D. Bechtel, Jr..

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.

Haploinsufficiency of progranulin causes frontotemporal dementia, and strategies to increase progranulin expression from the intact allele could have a therapeutic benefit.

For example, TDP - 43 toxicity has also been observed in frontotemporal dementia (FTD), a form of early - onset dementia that causes progressive memory loss.

«Staggering economic burden of dementia in younger people, study reveals: First - of - its - kind study on frontotemporal degeneration.»

Research published July 27 suggested that transcranial magnetic stimulation could prove useful in distinguishing Alzheimer's disease from frontotemporal dementia.

These symptoms arise because the mice contain a tau mutation that normally causes a related degenerative disease called frontotemporal dementia, which affects cognition and behavior.

«We hope that our study will provide a better understanding of the substantial socioeconomic burden of frontotemporal degeneration and deliver the needed evidence to help inform health care policy, drive research agendas, and enhance targeted allocation of resources that will lead to timely and accurate diagnosis as well as effective treatments where none exist today,» said Galvin.

The disorder is Frontotemporal Degeneration and the diagnosis came after Hinchey's successful battle with colon cancer in 2011.

KINGSTON, N.Y. >> Maurice Hinchey, who served the Mid-Hudson Valley for 38 years as a state assemblyman and congressman, has frontotemporal degeneration, a rare and terminal neurological disorder, his family announced Tuesday.

Strategies that boost the cell's quality control programs, rather than disarm specific pathologic proteins, have looked promising in lab animals that serve as models for human neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

Last month researchers led by Thomas Kukar, a professor at Emory University, published a paper showing that trehalose can reverse lysosomal deficiencies in mouse models of frontotemporal dementia.

You may not have heard of it, but frontotemporal degeneration (FTD) accounts for 20 to 50 percent of dementia cases in people under the age of 65.

«Frontotemporal degeneration is associated with substantial direct and indirect costs, diminished quality of life, and increased caregiver burden,» said James E. Galvin, M.D., M.P.H., lead author, associate dean for clinical research in FAU's Charles E. Schmidt College of Medicine, and a leading international expert on AD, Lewy Body Dementia (LBD), and FTD.

Miller has also seen physiological similarities in the brains of autistic savants and patients with frontotemporal dementia.