Sentences with phrase «full measure of the risks»

I urge the DEC and the Governor to pause in their deliberations and take full measure of the risks versus the benefits of this «gold rush» industry and make the right decision for this state for generations to come.»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Historically - reliable valuation measures are remarkably useful in projecting long - term and full - cycle market outcomes, but the behavior of the market over shorter segments of the market cycle is driven by the psychological inclination of investors toward speculation or risk - aversion.

There is also evidence to suggest that parental over-reliance on restrictive measures such as filters can itself be problematic, both by limiting children's opportunities to develop a full range of digital skills, and by making it less likely they develop resilience in dealing with online risks.

As a perfectly absurd example of how doctors have been wrongly influenced by the drug companies... about 8 years ago, I was a perfectly healthy 28 year old, in great shape, exercising daily, eating a balanced healthy diet full of antioxidants and quality nutrition, no smoking, and with no real risk factors for heart disease, and just because my cholesterol level has been consistently measured over 200 for my entire life, my doctor recommended I consider using a cholesterol lowering statin drug.

The Australian Early Development Census measures children in their first full year of full - time school and rates them as developmentally «on track», «at risk» or «vulnerable».

It measures children in their first full year of full - time school and assesses whether they're developmentally «on track», «at risk» or «vulnerable».

The Historical Monthly columns also report a variety of monthly risk and return measures over the full study period.

Obama is a deliberate man; he will abandon his measured centrism to acknowledge the full extent of the climate emergency only when he believes that the conditions are right, and the risk worth taking.

The court also noted a special review of whether the pesticide presented an unacceptable environmental risk to amphibians was required by the precautionary principle, which holds that given threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost - effective measures to prevent adverse health impact or environmental degradation.

Furthermore, the owner proposed various changes that would significantly lower the security risk, but the board did not «give the appropriate weight» to these alternative measures; • The board's refusal to consent to the changes unless the owner hired a full - time security guard unfairly disregarded the interests of the unit owner under section 135 of the Act.

In its guidance paper, the DFS also directed cryptocurrency firms to adopt measures that include effective implementation of a written policy to identify and assess the full range of fraud - related risk areas, including market manipulation.

A covariate was included in the multivariate analyses if theoretical or empirical evidence supported its role as a risk factor for obesity, if it was a significant predictor of obesity in univariate regression models, or if including it in the full multivariate model led to a 5 % or greater change in the OR.48 Model 1 includes maternal IPV exposure, race / ethnicity (black, white, Hispanic, other / unknown), child sex (male, female), maternal age (20 - 25, 26 - 28, 29 - 33, 34 - 50 years), maternal education (less than high school, high school graduation, beyond high school), maternal nativity (US born, yes or no), child age in months, relationship with father (yes or no), maternal smoking during pregnancy (yes or no), maternal depression (as measured by a CIDI - SF cutoff score ≥ 0.5), maternal BMI (normal / underweight, overweight, obese), low birth weight (< 2500 g, ≥ 2500 g), whether the child takes a bottle to bed at age 3 years (yes or no), and average hours of child television viewing per day at age 3 years (< 2 h / d, ≥ 2 h / d).

Several longitudinal studies have indicated that returning to full - time work after a brief maternity leave was a risk factor that compromised maternal mental health (depression and anxiety), especially when shorter leaves coincided with maternal fatigue, poor general health, poor social support, marital concerns, and other risk factors.17, 18 When mothers in the Wisconsin Maternity Leave and Health Study were contacted one year after they had given birth, no significant differences were noted between home - makers, part - time, and full - time employed women in measures of mental health such as depression, anxiety and self - esteem.

In Switzerland, where we conducted the study, most fathers in middle to high socioeconomic status families work full time — or close to full time — whereas the mothers at 3 months postpartum are mostly still on maternity leave, which may explain why a father's depressive state is less closely related to family functioning than is that of the mother in the first months, especially in cases of a mild or moderate depressive state, as we were able to measure in the present low - risk sample.