Sentences with word «fumigatus»

The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.

Because they and others had previously identified a particular sugar in the cell wall of A. fumigatus called GAG, short for «galactosaminogalactan», as critical to the fungus» ability to outwit the host immune system, the researchers started by testing whether differences in GAG production contribute to differences in the virulence (i.e. the ability to cause disease) observed among Aspergillus species.

Comparing A. fumigatus with the less pathogenic species A. nidulans, they found that the amount of cell wall - associated GAG correlated with the reported virulence of these species.

The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with...

Further experiments suggested that the production of high levels of cell wall - associated GAG makes A. fumigatus more resistant than A. nidulans to neutrophil killing by neutrophil extracellular traps, or NETs (NETs are are networks of extracellular fibers, composed of DNA and proteins secreted by immune cells called neutrophils, that bind and trap various pathogens).

In the new paper, the researchers map out how an enzyme in a common mold species called Aspergillus fumigatus adds a pair of oxygen atoms to a toxin the mold produces.

The fungus Aspergillus fumigatus produces a group of previously unknown natural products.

Someday, a version of S12 that's modified to work in humans might be able to boost these patients» defenses against A. fumigatus infections, Hohl suggests.

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence.

The pH - responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

Large - scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA.

Donald Sheppard, from the Research Institute of the McGill University Health Centre in Montreal, Canada, and colleagues set out to explore features that could facilitate infection by A. fumigatus as compared with less pathogenic Aspergillus species.

A previously unknown group of compounds produced by the fungus Aspergillus fumigatus can block an enzyme implicated in the build - up of cholesterol in arteries.

Although more than 250 different Aspergillus species are found in nature, and most contribute spores to the air we breathe, over 80 % of human disease is caused by one particular culprit called Aspergillus fumigatus.

The most worrisome and abundant organism Woodcock found in pillows was Aspergillus fumigatus, an asthma - aggravating bacterium that can prove deadly to people with depressed immune systems, such as leukemia and transplant patients.

As their results highlight the importance of GAG as a key virulence factor of A. fumigatus, they suggest that targeting GAG may be an effective antifungal approach in some human patients.

Increasing cell wall - associated GAG in A. nidulans enhanced resistance to NETs and increased the virulence of this species to the same level as A. fumigatus in immune - compromised mice with intact NET formation.

Scanning electron microscopy illustrates the difference in the abundance of cell wall - associated galactosaminogalactan (arrows) between the opportunistic fungal pathogen Aspergillus fumigatus and the minimally pathogenic species Aspergillus nidulans.

Their study, the researchers say «establishes a role for cell wall - associated GAG in mediating resistance to killing of Aspergillus by NETs and provides the first example of a virulence factor of A. fumigatus that is able to mediate enhanced virulence when expressed in a less pathogenic Aspergillus species».

Collectively, these data suggest that A. nidulans is more sensitive than A. fumigatus to NETs due to lower overall levels of cell wall - associated GAG.

Found naturally in soil and decaying organic matter, the fungus, Aspergillus fumigatus, releases airborne spores that are found in small doses in the air people breathe every day.

FUNGUS AMONG US Aspergillus fumigatus (shown) is a common fungus found in soil.

Hohl did this research with a special variety of A. fumigatus that changes color when its suicide instructions kick in.

Hohl and colleagues identified a gene in A. fumigatus that puts the brakes on programmed cell death.

This work led to Inz - 5, which exhibited dramatically improved potency and selectivity for fungal cytochrome B. Although cytochrome B is highly conserved across humans and many pathogenic fungi, including Cryptococcus neoformans, Aspergillus fumigatus, and Rhizopus oryzae, Inz - 5 exploits important differences in the amino acid sequence of the protein that enable selectivity for fungi.

They have been working to combat biofilms for several years, focusing on two of the most common organisms responsible for lung infections: a bacterium called Pseudomonas aeruginosa and a fungus called Aspergillus fumigatus.

They found a promising lead in a soil sample from the Shinjuku area of Tokyo which contained a particular strain of A. fumigatus.

A. fumigatus is harmless to healthy people, but for those whose immune systems are impaired by AIDS or immunosuppressive drugs, it can set up an infection in the lungs which is usually fatal.

The fungus Aspergillus fumigatus (in red) produces a sticky sugar molecule (in green) to make a biofilm that is important for its virulence.

In particular, we focus on the common mold Aspergillus fumigatus, which causes pneumonia in patients who have received chemotherapy, organ transplantation, bone marrow transplantation or high dose cortisone therapy.

Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen.

He directed the international project that determined the first genome sequence of Aspergillus fumigatus, the fungal pathogen that causes the frequently lethal infection, invasive aspergillosis.

Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus.

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.

(NewsUSA)- Up to half of all cystic fibrosis patients have fungal infections in their lungs caused by a spore - forming mold named Aspergillus fumigatus.

«There is an emerging body of literature showing a terrific phenotypic variation in A. fumigatus.»

«For people wanting to draft policy, either sampling or cleaning regimes aboard these space vessels, the study shows that if a fungus is identified as A. fumigatus, any and all isolates represent potential pathogens and should be treated as such,» said Mr. Knox.

Since A. fumigatus is the most significant airborne opportunistic mold pathogen of humans, it is likely to be an issue on space vessels.

In the new study, led by Benjamin Knox, a microbiology graduate student at University of Wisconsin - Madison, scientists compared two isolates of A. fumigatus that were isolated from the International Space Station to reference isolates from earth.

Together with his group he has identified general immune evasion strategies which are shared by pathogenic microbes, including the human pathogenic yeast Candida albicans and Aspergillus fumigatus, as well as other pathogens, such as Gram negative and Gram positive bacteria.

Human pathogenic fungi like Candida albicans and Aspergillus fumigatus can exist in healthy individuals as benign components of the mucosal flora, however these fungi can also display pathogenic features and then cause mucosal diseases, up to life - threatening bloodstream infections, sepsis and invasive pulmonary aspergillosis which cause substantial morbidity.

Moreover, it also destroys other pathogens such as, Aspergillus fumigatus and Aspergillus niger.

Aspergillus fumigatus is classed as an opportunistic pathogen because it will only infect an individual whose immune system does not work properly.