Not exact matches
Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune
function in patients, particularly those undergoing immunosuppression
after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.
Transplant recipients with low urinary CXCL9 protein six months
after transplantation were unlikely to experience rejection or loss of kidney
function over the next 18 months.
This follows experiments with mice in which genetically modified liver cells survived and continued to
function for more than a year
after being
transplanted.
But now, scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF), have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully
functioning liver cells that flourish on their own, even
after being
transplanted into laboratory animals modified to mimic liver failure.
After the artificial node had filled with antigen - specific T and B cells, Watanabe
transplanted it into a mouse with no
functioning immune system.
Between 2004 and 2014, 477 patients treated with BMT at City of Hope underwent standardized neuropsychological testing before their
transplant, and at the six - month and one -, two - and three - year marks
after transplant; testing was conducted on eight cognitive domains, including executive
function, verbal fluency and speed, processing speed, working memory, visual and auditory memory, and fine motor dexterity.
After seeing significantly improved long - term survival and integration of the
transplanted cells, the next step was to see if the cells actually
functioned.