Sentences with phrase «function by mitochondria»

If replicated, the tantalizing finding could fit with an emerging theory that subpar function by mitochondria, the organelles that provide energy for cells, drives the disease.

Not exact matches

The affected mitochondria could no longer provide the synapses with enough energy, which ultimately prevented the synapses from functioning — providing the first direct link between cellular injury caused by amyloid protein and the characteristic breakdown of neuronal communication that occurs in Alzheimer's patients.

But the big question remaining is whether the child's health will be affected by the traces of the mother's mitochondrial DNA that he carries, which could prompt some of his mitochondria to function improperly.

The additional energy stabilizes cell function and prevents premature cell death often caused by defects in mitochondria.

The loss of beta cell function may be driven by a defect in Clec16a, a gene responsible for getting rid of old mitochondria, the powerhouses of cells, and making room for fresh ones.

They found that by attaching to a mitochondrial protein called TOM20, alpha - synuclein prevented the mitochondria from functioning optimally, which resulted in the production of less energy and more damaging cellular waste.

Second, by disturbing the function of the mitochondria, the cells» power stations, the drugs caused HIV - infected cells to self - destruct while sparing healthy cells.

The scientists showed that NR and NAD + prevent hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in the function of mitochondria, the powerhouses of the cell.

We have begun to investigate the properties of mitochondria in ME / CFS further by examining how well they function in white blood cells, relative to healthy individuals.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

L - carnitine functions as a carrier molecule that transports activated long - chain fatty acids from the cytosol to mitochondria where ATP is produced by metabolizing fatty acids.

This store of phosphocreatine is also replenished by the mitochondria following muscle contraction and a measure of mitochondrial efficiency is the time taken for replenishing these stores: better mitochondrial function is linked to shorter times of phosphocreatine recovery.

Aside from producing heat, far infrared may also increase mitochondria function by structuring the water molecules that surround the mitochondria.

Mice given astaxanthin were found to have accelerated body fat reduction (i.e., «fat burning») when combined with exercise, as compared to exercise alone in a 2007 study by Aoi et al. 9 Aoi reports the carotenoid seems to exert this effect by protecting the function of a lipid transport enzyme on the membrane of mitochondria that «fuels» energy production.

Optimizing mitochondrial function can be done by ensuring that the body gets the right nutrients and precursors necessary for mitochondria function.

Researchers think that CoQ10 supplementation may help cells function more normally and divide more normally by restoring energy to the mitochondria in each cell.