Sentences with phrase «function in cancer cells»

«Studying gene function in cancer cells is now a lot more straightforward and will continue to get easier as even newer technologies are developed,» says Waldman.

Not exact matches

It also boosts the body's immune response against infections and cancer cells and plays an important role in thyroid function and fertility.

Curcumin in turmeric has the ability to modulate genetic activity and expression — both by destroying cancer cells and by promoting healthy cell function.

With microRNA - 210 in check, cells regain their normal function and cancer can not grow.

Changes in the normal function of Ras proteins — mutations which are responsible for 30 percent of all cancers — can power cancer cells to grow and spread.

Lewis is now skimming through these genes to check their function; of those he's looked at so far, several are involved in growth and development, cell differentiation, cell death, and protecting against cancer.

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

In the early 1990s, in vitro tests on cancer cells by Lane and his colleagues hinted that some compounds could restore mutant p53's normal functioIn the early 1990s, in vitro tests on cancer cells by Lane and his colleagues hinted that some compounds could restore mutant p53's normal functioin vitro tests on cancer cells by Lane and his colleagues hinted that some compounds could restore mutant p53's normal function.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

However, when these cells choose the wrong function this can result in severe inflammation leading to conditions such as inflammatory bowel diseases and even cancer.

Óscar Llorca and his team have used this technique to learn about the structure and functioning of a complex system called R2TP, which is involved in various key processes for cell survival such as the activation of the kinases mTOR, ATR and ATM, proteins that are the target of various cancer drugs currently being developed.

How microRNAs might intercept immune cells in cancer is unknown and we were able to provide insight into a critical means by which cancer cells exploit miR - 183 to dampen immune cell function.»

«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

«It is currently impractical to directly restore Apc function in patients with colorectal cancer, and past evidence suggests that completely blocking Wnt signaling would likely be severely toxic to normal intestinal cells,» Lowe says.

Keep in mind that the vast majority of mutating agents provoke cells to stop functioning or to die, meaning there is no chance for those mutations to cause cancer.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

As cell phones and smart phones take over more communication, information and entertainment functions, concerns about their possible role in causing brain cancer are buzzing on the airwaves.

In the April 25 issue of Cancer Cell, a research team, led by Xin Lu, PhD, Ludwig director and member at the University of Oxford and a team of scientists from both institutions, describes how p53 is silenced in advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cellIn the April 25 issue of Cancer Cell, a research team, led by Xin Lu, PhD, Ludwig director and member at the University of Oxford and a team of scientists from both institutions, describes how p53 is silenced in advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cellin advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cellin such cells.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

Resar says the team plans to continue investigating the function of HMGA1 and SOX9 in intestinal and other cancers as well as their role in stem cells.

In summary, less Cdh1 prevents the normal function of APC / C, which eventually inhibits the degradation of PAX3, potentially leading to unregulated cell proliferation and cancer (melanoma in skin cell modelsIn summary, less Cdh1 prevents the normal function of APC / C, which eventually inhibits the degradation of PAX3, potentially leading to unregulated cell proliferation and cancer (melanoma in skin cell modelsin skin cell models).

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

A given gene may perform a different function in breast cancer cells than in healthy cells due to changes in networks of interacting proteins, according to a new study published in PLOS Computational Biology.

The molecule CD103 is key to the long - term residence of T cells in the skin and to their anti-tumor function, report a team of researchers at the Medical University of South Carolina (MUSC) and the Dartmouth - Hitchcock Norris Cotton Cancer Center In the April 14, 2017 Science Immunologin the skin and to their anti-tumor function, report a team of researchers at the Medical University of South Carolina (MUSC) and the Dartmouth - Hitchcock Norris Cotton Cancer Center In the April 14, 2017 Science ImmunologIn the April 14, 2017 Science Immunology.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

He is researching the functions and properties of human sulfotransferase (EST) enzymes in human breast cancer cell lines.

But in malignant cancer, normally healthy cell functions often lunge into destructive overdrive.

In fact, in these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugIn fact, in these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugin these studies, the drug functioned better in upsetting these cancer cells» activities than many FDA - approved cancer drugin upsetting these cancer cells» activities than many FDA - approved cancer drugs.

• Given the fact that normal cells possess wild - type p53 function, FL118 - induced p53 activation might explain the favorable toxicology profile of FL118: highly toxic to cancer cells but not so in healthy animal cells, and these different consequences might be mediated through p53 activation.

Stress can cause changes in the function of the immune system, including reducing the number of natural killer cells that are known to battle cancer.

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

Researchers at the Institute for Basic Science (IBS) in South Korea have succeeded in developing the world's first technology to control specific protein functions in living cells by using lights, which may be useful in future cancer cell research.

«I wouldn't be surprised, and this is a bit of speculation, if GATA - 3 may have a function in promoting certain breast cancer and T - cell leukemia through promoting the MYC pathway.»

The protein GATA - 3 plays an important role in mammalian immune response, but its overall function in cell development and cancer formation is not well understood.

«We want to know what the basic function of GATA - 3 in regulating cell biology is, although it has been shown that GATA - 3 is important for the function of CD4 + T cell type to clear extracellular parasites,» said Yisong Wan, PhD, assistant professor of microbiology and immunology at the UNC School of Medicine and member of UNC Lineberger Comprehensive Cancer Center.

Two men with prostate cancer, cells in a petri dish, a loss of function that may or may not translate into pathogenicity: This does not merit my mental energy.

«This information yields new insights into how sperm stem cells function and develop under normal circumstances,» says the study's lead author Bradley Cairns, PhD, senior director of basic science at HCI and professor and chair of oncological sciences at the U of U. «We have built a very important framework we can now use to help us understand what happens when things go wrong, resulting in issues like infertility and cancer in men.»

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

For hormone - receptor positive cancer cells, hormone - receptor therapy can be used to interrupt the role of hormones in the cells» growth and overall function.

In a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changeIn a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changein T cell exhaustion to some of these epigenetic changes.

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail - safe mechanism that may protect us from cancer.

The Hedgehog signalling pathway is a good target for cancer researchers because it mainly switches back on in cancer cells and so blocking its function does not overly affect signalling in healthy cells.

Using genetic techniques, the Imperial team knocked out the Hhat function in pancreatic cancer cells and, as they hoped, the cancer cells showed substantially reduced growth and ability to spread in a test - tube assay.

With molecular biologist Gregory Hannon of Cold Spring Harbor Laboratory in New York state, Elledge developed genetic tools that examine how genes function in human cancer cells.

«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»