By enhancing
the function of a single protein, Howard Hughes Medical Institute researchers have produced a «marathon mouse» with altered muscle composition and enough physical endurance to run twice...
Not exact matches
In these and other inherited diseases, 10 to 15 percent
of the
single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle
of the gene — causing the machinery
of the cell to prematurely halt synthesis
of the
protein, which destroys its ability to
function.
Recent work also shows that some plants, such as the cabbage and mustard relative Arabidopsis, make
proteins that are involved in the development and
functioning of eyespots — the ultrabasic eyes found in some
single - celled organisms such as green algae.
With sharper tips and improved antenna
function, we also hope to obtain infrared spectra
of single proteins in the future.
As a postdoc in the lab
of Zefeng Wang, PhD, a member
of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for
proteins involved in alternative splicing — when a
single gene organizes its genetic code to create different
proteins with various
functions.
Through the combination
of linkage data and exome sequencing, they have identified a deletion or loss
of a
single base in the gene encoding STAG3, which results in a prematurely truncated
protein without
function.
Synonymous
single - nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the
function of the
protein in which they occur.
Christopher Jaroniec, professor
of chemistry and biochemistry at The Ohio State University, said that the findings highlight the fact that minor alterations in
single amino acids can cause profound differences in structure and
function among this family
of proteins.
January 7, 2016 Scientists find ancient mutation that contributed to the evolution
of multicellular animals A
single chance mutation about a billion years ago caused an ancient
protein to evolve a new
function essential for multicellularity in animals, according to new research co-led by a University
of Chicago scientist.
A persistent challenge in unraveling mechanisms that regulate memory
function is how to bridge the gap between inter-molecular dynamics
of single proteins, activity
of individual synapses and emerging properties
of neuronal circuits.
Consistent with this, WDR26 loss -
of -
function single - nucleotide mutations identified in these subjects lead to nonsense - mediated decay with subsequent reduction
of RNA expression and
protein levels.
Studies cover a breadth
of topics ranging from
single molecules (molecular motors, DNA -
protein interactions, membrane
proteins) to cellular
functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour
of cells in tissues and organisms (wound healing, morphogenesis).
Most mixed meals will keep your insulin levels high enough to stop
protein breakdown for 4 - 6 hours.9 A 45 - gram dose
of whey
protein will do the same for about two hours.10 Technically, a
single meal before your workout could ``...
function as both a pre - and an immediate post-exercise meal...,» writes Aragon and Schoenfeld.3
The undenatured whey
protein that proved useful for boosting glutathione and immune
function in mice was produced with a
single round
of «classical» pasteurization at 63 C for 30 minutes, which led to an even greater destruction
of serum albumin, resulting in a total loss
of 52 percent
of the whey's glutathione - boosting power.