The six previously known fly rhodopsins account for the full
function of photoreceptor cells in the fly's eyes, so although the fruit fly genome contained the sequence of a seventh rhodopsin, the role of Rh7 was unclear.
Not exact matches
He suspects that transplanted
cells are actually restoring the
function of «dormant»
photoreceptors.
The retinal pigment epithelium (RPE) is a single layer
of cells that accomplishes multiple
functions, such as providing survival molecules that prevent
photoreceptors from dying.
The RPE is a single layer
of cells lining the back
of the retina that is vital to the
functioning of the retinal
photoreceptor cells, and thus vision itself.
With age, our eyes accumulate waste in retinal pigment epithelium (RPE), which supports the life and
function of photoreceptors (light sensitive
cells in the eye); in advanced stages, RPE and
photoreceptors die.
One can imagine that loss
of function of any
of the gene products along this complex pathway could lead to severe consequences for the survival
of the
photoreceptor (PR)
cells in the eye.
Of note, while vision rescue requires preservation of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61
Of note, while vision rescue requires preservation
of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61
of some functional
photoreceptors, the mere presence
of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61
of photoreceptor cells in the ONL
of transplanted RCS rats does not assure function [61
of transplanted RCS rats does not assure
function [61].
It is likely that those
cells would then support the
function of the very important
photoreceptor cells in the retina.
The retinal pigment epithelium (RPE) is a monolayer
of cells, residing at the back
of the eye between Bruch's membrane and the retina, which is essential for
photoreceptor function and survival.
As a monolayer
of cells critical to
photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.
The gene product's precise role is not currently understood but it is thought to anchor regulatory complexes at the
photoreceptor connecting cilium, which acts as a bridge between the inner and outer segments
of photoreceptor cells [43] as well as having
functions in disk morphogenesis [42] and in the structure
of the ciliary axoneme [44].
ERG abnormalities are evident by 5 — 6 weeks
of age and
cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain
of function that severely compromises the early stage
of development
of the
photoreceptors.
Whereas the genes implicated in early - onset diseases are those necessary for the correct development
of photoreceptors the genes associated with later - onset forms
of disease are those necessary for the long - term maintenance and
function of these
cells.