Sentences with phrase «function of the gene»

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

Furthermore, despite the claim that evolution has no application, phylogenetic comparisons of humans and other organisms allows us to identify the precise location and putative function of genes responsible for developmental disorders.

In other words, they now have total control over that genome and can examine the function of every gene, seeing if each part of the genome serves a biological function or is redundant.

Genetic modification is a useful tool to help us understand the function of genes.

Published in GigaScience, the open source Galaxy workflow allows researchers to make easier work of finding gene families; an important tool when it comes to analysing the evolution, structure and function of genes across species.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

The answers could help open many doors in medicine and greatly expand our understanding of the functions of genes.

The function of the EST — or at least the function of the genes from which they are derived — is therefore known.

Although the function of the gene isn't fully established, it is thought to add sugars to proteins, which could alter the speed or specificity of their usual function.

With rapid advances over the past 10 years in technologies for discovering and analyzing the functions of genes, researchers are now increasingly able to get at the biological roots of complex disorders such as substance abuse and addiction.

Understanding the function of this gene — described this month in journal Molecular Psychiatry — could lead to more effective treatments for schizophrenia.

Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the specific function of those genes and gene networks.

All this enabled them to systematically whittle away genes that either had nonessential functions or duplicated the function of another gene.

However, resistance to therapy might go beyond cancer mutations that usually alter the function of genes.

These adducts may also change the functions of genes that promote or suppress disease, although exactly how they might lead to developmental decrements in fetuses exposed to them is unclear.

Researchers at the ARC Centre of Excellence in Plant Energy Biology at the University of Adelaide's Waite campus then investigated the function of this gene.

In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).

IMPC builds on the groundwork and achievements of EUMODIC in establishing the procedures and processes to identify and catalogue the function of genes.

In the next phase of the study, we will examine and categorize the functions of the genes that we identified — not only in model organisms, but also in agriculturally and economically important crops such as corn.»

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

«Certainly, a lot of details are still unclear especially with regard to the function of genes.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

Although the functions of these genes match well with the environment in which woolly mammoths were known to live, Lynch warns that it is not direct proof of their effects in live mammoths.

«If you line up these [variants] and determine the likely function of the genes, do they tell the same story?»

The difficulties are well illustrated by last month's rejection of a patent application in the US, by the Institutes of Health, for DNA sequences without knowledge of the function of the gene.

Researchers checked the genomes of 150 patients with schizophrenia and those of 268 healthy people, looking for large duplications and deletions of genetic material that disrupted the function of a gene.

The function of this gene is well established: metabolism of lipids, including blood lipids (e.g., cholesterol and triglyceride) and omega3 / 6 polyunsaturated fatty acids (PUFA).

The scientists then explored the function of this gene through experiments in mice.

«These findings help us to understand where in the body the function of this gene is vital and how the loss of the gene in certain tissues can give rise to Menke's disease,» said Petris, who is a researcher in the Bond Life Sciences Center and holds an appointment in the Department of Nutrition and Exercise Physiology.

The variant has been found in two men with prostate cancer, and in vitro analysis suggests it causes a partial loss of function of the gene.

«What we are trying to do is identify the function of genes and how they affect the way the individuals process information and the structure of the brain.

«There's never been a really good way of looking at the function of all genes in any apicomplexan parasite,» says Whitehead Fellow Sebastian Lourido.

On 18 March, the EC announced the creation of three pan-European projects, including the twin study, a new project to identify the function of genes in mutant mice, and an effort to determine the structures of disease - related proteins.

With additional information on the functions of these genes, «one could predict a risk of relapse metastasis disease showing up years later and the site at which it would come back,» says Massagué.

Researchers have developed a set of genetic switches that can be built into engineered organisms, to control the function of genes they need to survive.

Their findings shed new light on the animal's complex biology, including insight into the function of genes linked to immunity and meat quality.

Chemical compounds that affect the functioning of genes can bind to our genetic material, turning certain genes on or off.

«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.

This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease.

If the function of these genes can eventually be worked out, treatments might be found to improve the mental capacity of patients carrying damaged copies.

Brunner, who is based in the Department of Forest Resources and Environmental Conservation and is affiliated with the Fralin Life Science Institute, contributed her knowledge of genetic mechanisms, development processes, and function of genes to the study.

Researchers plan to test the function of these genes in future space station experiments.

«We have deposited all the data and the toolkit in a public platform, which will help researchers identify and validate the functions of their genes of interest,» says Auwerx, placing the project within the context of EPFL's ongoing efforts to advance open science.

Work ranges from analysis of the functions of genes identified to cause eye diseases when mutated, to the direct effects of UV - light and other agents associated with the development of eye disease on mitochondrial and other cell functions.

Just like we test hypotheses about the functions of genes in genetic networks by knocking them out and replacing them, we need methods to selectively remove or inhibit specific microbes or metabolisms in microbial networks to determine their roles,» Brodie added.

His efforts are directed toward understanding the nature and function of genes that control these processes and how disturbances in gene networks may lead to cancer.

SNPs, pronounced «snips», are common and most don't change the function of the gene.

There was zero discussion of the known functions of these genes in this paper, so it's difficult to say.

«We want to characterize each line of mice broadly with no assumptions about what the gene is or is not doing,» said IMPC Executive Director Mark Moore, Ph.D. «If you think of the function of a gene as a needle in a haystack, we're removing the haystack so you can see what the needle does.»

The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.