Sentences with phrase «function of their activation»

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

Not exact matches

Prior to the development of a fully functioning nervous system, and the activation of said system, a human embryo is «alive» in the same sense a tumor is «alive»: the individual cells that make it up are alive, but there is no higher - level functionality.

The woman orgasm has a positive impact on the baby, because of the activation of the placenta function and the secretion of the hormone of happiness, endorphin, which also makes the baby feel happy.

In addition, because it tests for verbal memory, the SAC can not identify athletes who may suffer measurable impairment of neurocognitive function (primarily visual working memory) on neurocognitive tests, as well as altered activation in neurophysiologic function on sophisticated brain imaging tests (fMRI), resulting from repeated sub-concussive blows to the head.

Although scientists have long suspected that RHI caused brain damage, especially in boxers, a 2010 study of high school football players by researchers at Purdue University [1,13] was the first to identify a completely unexpected and previously unknown category of players who, though they displayed no clinically - observable signs of concussion, were found to have measurable impairment of neurocognitive function (primarily visual working memory) on computerized neurocognitive tests, as well as altered activation in neurophysiologic function on sophisticated brain imaging tests (fMRI).

If, because of extended separation, these hormones are not soothed by contact with the mother, the baby can go into psychological shock, which, according to author Joseph Chilton Pearce, will prevent the activation of specific brain functions that is nature's blueprint for this time.

Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release.

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

Óscar Llorca and his team have used this technique to learn about the structure and functioning of a complex system called R2TP, which is involved in various key processes for cell survival such as the activation of the kinases mTOR, ATR and ATM, proteins that are the target of various cancer drugs currently being developed.

CED - 4 translocation induced by the cell - death activator EGL - 1 was blocked by a gain - of - function mutation in ced - 9 but was not dependent onced - 3 function, suggesting that CED - 4 translocation precedes caspase activation and the execution phase of programmed cell death.

Since a primary function of the dendritic cells is to present an antigen to T - cells, to activate the T - cells and begin the immune response, the researchers suspected that T - cell activation in the heart tissue, and perhaps heart - tissue injury caused by T - cells, might be central to the pathological heart enlargement that is called remodeling.

The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that encodes tyrosine aminotransferase (TAT).

• Given the fact that normal cells possess wild - type p53 function, FL118 - induced p53 activation might explain the favorable toxicology profile of FL118: highly toxic to cancer cells but not so in healthy animal cells, and these different consequences might be mediated through p53 activation.

«The current study was designed to determine the effect of inhibition of platelet activation and function by aspirin therapy on colon and pancreatic cancer cell proliferation,» the researchers wrote.

Too much activation of p38 MAPK in glial cells impairs their supportive function and can result in the release of neurotoxic molecules further harming the synapse.

Over activation of p38 MAPK damages the synapses and alters the normal functioning of neurons, impairing communication.

Kim Cecil, a chemist and professor of radiology at Cincinnati Children's Hospital Medical Center and an expert on the impact of lead on the brain, has found that whereas the language - function region of the brain's left hemisphere is perturbed by chronic lead exposure, corresponding regions in its right hemisphere show increased activation in the presence of blood lead levels above current levels of concern.

«In previous research, we showed that patients with Parkinson's disease use cognitive function, which is reflected in activation of the pre-frontal cortex of the brain, to compensate for impaired motor function,» Prof. Hausdorff says.

«We have found that 10 % of colon and stomach tumors present the loss of a molecule called TP53TG1, whose function in healthy cells is to prevent activation of YBX1 protein.

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

The researchers also screened out participants with concussions, which can disrupt patterns of brain activation and function, Scherf added.

In cancer, PAT function has been related to the amino acid - sensing engine that drives activation of the mammalian target of rapamycin complex 1 (mTORC1), which is an important target for existing and new anti-cancer drugs.»

The paper «Non-canonical function of SAC proteins after APC activation reduces aneuploidy in mouse oocytes» is published in the journal Nature Communications and was funded by the Australian Research Council.

«We can clearly demonstrate that the activation of the secretion system is the main function of the protein EIIAGlc, while the many other described metabolic functions play a minor role in the occurrence of illness,» says Bumann bringing his findings to the point.

Genetic analysis also revealed significant increase in activity in two genes that may be involved in mitochondria function, suggesting that osteoclast activation might be linked to the reaction of mitochondria to microgravity.

When the research team used pharmaceuticals to inhibit one function of the endoplasmic reticulum (the building of so - called lipoprotein particles that will export fats out of the cell), the gene activation process was inhibited for many key genes and nuclear ruffling was also altered.

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

Transforming growth factor β / Smad3 signaling regulates IRF - 7 function and transcriptional activation of the β interferon promoter.

He uses the paradigm of nuclear hormone receptor activation / signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells, such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems.

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

For my masters project I studied the relationship between sociality and fitness in the rhesus macaque through non-invasive markers of immune activation and HPA axis function.

Tatsiana Audzevich (Jessberger, TUD)-- «The function of SWP - 70 in CD40 / IL -4 induced beta cell activation and immunoglobulin E class switch recombination» (2009)

Additionally the functional effects of DBS will be explored in several ways 1) we will look at changes in brain activation patterns in response to specific tasks by means of functional MRI 2) we will look at the striatal D2 binding using [123I] IBZM SPECT 3) we will look at neuropsychological functioning using cognitive tasks.

This involves a feedback loop where BZR1 directly represses certain boundary identity genes (e.g., CUC and LOF) and others (e.g., LOB) function to keep BR from accumulating in the boundaries through direct activation of BAS1 (Neff et al., 1999; Bell et al., 2012).

The impact of Ex Vivo clinical grade activation protocols on human T - cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy.

9:40 Rolf K. Berge, Section of Medical Biochemistry, Department of Internal Medicine, Haukeland University Hospital: «Metabolic syndrome in relation to mitochondrial function and PPAR activation»

Location and function of STIM1 in the activation of Ca2 + entry signals.

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2 - mediated Rac activation and actin polymerization.

Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.

In human cells, mebendazole suppressed the formation of the primary cilium, a microtubule - based organelle that functions as a signaling hub for Hh pathway activation.

Lipid rafts regulate lipopolysaccharide - induced activation of Cdc42 and inflammatory functions of the human neutrophil.

Physiological levels of interleukin - 18 stimulate multiple neutrophil functions through p38 MAP kinase activation.

Rituximab is thought to function through activation of natural killer cells, resulting in cellular cytotoxicity.

Activation of integrin function by nanopatterned adhesive interfaces.

Moreover, DDX3 is identified as a subunit of mammalian Mediator complex (9) and has a transcriptional activation function (1).

Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.

Activation of the UPR induces the production of a family of basic leucine zipper - containing transcription factors that activate transcription of genes encoding functions to reduce the protein - folding load and increase the protein folding capacity of the ER.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

(6) However, it would be useful to see a more thorough analysis of the effect of ablating p16Ink4a - expressing senescent cells, and whether there may instead be evidence of a short - term rejuvenation of tissue function that is slowly lost over time to rising levels of other kinds of aging damage that INK - ATTAC activation does not address.

The adenosine A ₂ ₐ receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells and binding of adenosine to the A ₂ ₐ receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.