Thus, such mutations might alter the protein
function on chromatin state regulation, sensitizing PTCL - NOS patients to HDAC inhibitors.
The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and
chromatin remodeling, and is focused
on elucidating the
function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.