Sentences with phrase «functional gene annotation»

In light of this, homology - based methods of functional gene annotation will be suitable for only a subset of the genome.

Functional gene annotation was performed using dammit, Gene Ontology (GO), KOG (WebMGA) and KEGG pathway analyses (Kaas).

Not exact matches

We tested the top ten percent of the genes expressed in each stage of lactation for significant enrichment of functional annotations.

The RNA - guided endonuclease Cas9 is a versatile genome - editing tool with a broad range of applications from therapeutics to functional annotation of genes.

In terms of functional groups rather than individual genes, of the 51.4 % Bt genes with COG annotations, those related to carbohydrate transport and metabolism comprised 10 % of the input library.

When they compared the results to the Mouse Genomic Informatics Knockout database they found 123 genes that corresponded with functional annotation of abnormal extraembryonic tissue morphology, 121 associated with embryonic lethality, and 14 with abnormal embryo implantation.

Phenotype data from 449 mutant alleles were acquired, representing 320 unique genes, of which half had no previous functional annotation and data from over 27,000 mice were captured, finding that 83 % of the mutant lines are phenodeviant, with 65 % demonstrating pleiotropy.

Appendix 1 shows the identities, functional annotations, and relative expression ratios of these genes.

I prioritised variants and genes using case - control comparisons and functional annotations such as types of mutation, evolutionary conservation status and regulatory marks.

Functional annotations from Ensembl BioMart, TAIR10, Phytozome, and MaizeGDB were based on homologs determined through Ensembl Compara gene trees (gramene.org).

Differentially expressed genes in bsl1 - 1 mutant inflorescences and functional annotations.

This indicates that a comprehensive and experimentally supported annotation effort of the human genome simultaneously highlights regions with striking differences in gene organization to other species and may indicate evolutionary events specific to the human lineage demanding further functional analyses.

In the absence of functional annotation, genes encoding immune system proteins can thus be difficult to identify, as homology - based approaches generally can not detect lineage - specific genes.

Establish collaborative «networks» with specialist phenotyping consortia or laboratories, providing standardized secondary phenotyping that enriches the primary dataset, and end - user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

«Researchers at the Novartis Institute for Functional Genomics have launched Biology Gene Portal Services, or BioGPS, a gene portal designed to display gene - centric annotation that can be customized for individual users...&raGene Portal Services, or BioGPS, a gene portal designed to display gene - centric annotation that can be customized for individual users...&ragene portal designed to display gene - centric annotation that can be customized for individual users...&ragene - centric annotation that can be customized for individual users...»

An extensive analysis of the whole - genome, including annotation of predicted genes and assignment of functional categories, analysis of chromosomal architecture and the distribution of transposable elements, and comparisons with other genomes, is presented with the publication of the sequences of chromosomes 1, 3, and 5.

We find evidence of expression for all VR, and almost all OR genes that are annotated as functional in the reference genome, and use the data to generate over 1100 new, multi-exonic, significantly extended receptor gene annotations.

Functional annotation was done by comparing the reads against the Clusters of Orthologous Genes (COGs)[45] and TIGRFAMS [46] databases using RPSBLAST [47](E-value cut - off of 10 - 5).

We integrate functional genomic datasets with up - to - date gene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematGene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematode.

This makes them ideal to predict gene function, by transferring known functional annotations from orthologs in model organisms.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

The functional annotations of all the clusters with ≥ 10 transcripts, which were obtained using the on GO classification categories of the g: Profiler tool for all the genes in each cluster, are shown in Table 2 (for downregulated genes during ES cell differentiation) and Table 3 (for upregulated genes).

There was no significant enrichment of genes in any functional category; however, GO annotations revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of cell differentiation,» «Wnt receptor signaling pathway,» and «gland development.»