Sentences with phrase «functional gene in the mouse»

The challenge then is to replace the intact, functional gene in the mouse chromosome with the modified version created in the test tube.

Not exact matches

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

To infer the functional effects of these differences, they ran multiple computational analyses, including comparisons to massive databases of known gene functions and of mice in which genes are artificially deactivated.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in micIn the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in micin breast cancer - derived cell lines and in human breast cancers replicated in micin human breast cancers replicated in micin mice.

Finally, the functional inactivation of our target gene by one identified pharmaceutical agent will be tested in DM1 mouse model in order to monitor its ability to impact in vivo on DM1 molecular and physiological features.

Early gene therapy confers structural and functional rescue to cones in two models of RPE65 deficiency: rd12 and Rpe65 - / - Rho - / - mice.

Functional KL2 genes were delivered to the mice using lentiviral vectors, based on a crippled version of HIV that was first developed by Verma and Salk Institute colleagues in 1996.

Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot - Marie - Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia.

Largaespada's laboratory is working to exploit insertional mutagenesis for cancer gene discovery and functional genomics in the mouse.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic mapIn 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic mapin model organisms with the phenotypic annotations on the human and mouse genetic maps.

CELPHEDIA with the partners of PHENOMIN (ICS, TAAM, CIPHE), the National Infrastructure for Mouse Phenogenomics, is committed in international consortia, such as IMPC «International Mouse Phenotyping Consortium» whose goal is to create the functional encyclopedia of the mouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functMouse Phenogenomics, is committed in international consortia, such as IMPC «International Mouse Phenotyping Consortium» whose goal is to create the functional encyclopedia of the mouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functMouse Phenotyping Consortium» whose goal is to create the functional encyclopedia of the mouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functmouse genome by achieving inactivation mutants of every mouse gene and by performing their exhaustive phenotyping for all major physiological functmouse gene and by performing their exhaustive phenotyping for all major physiological functions.

Aβ - 42 was detected in the spinal fluid and hippocampus of mice that lacked NEU1, but not in mice with a functional NEU1 gene.

Thus, we turned to the laboratory animal model, the mouse, for an in - depth gene expression and functional analysis.

To investigate gene networks operating in pluripotent ES cells and their derivatives, the «Functional Genomics in Embryonic Stem Cells» consortium (FunGenES) has analyzed the transcriptome of mouse ES cells in eleven diverse settings representing sixty - seven experimental conditions.

Our approaches include gene discovery, mapping of signaling networks in cell culture models and in vivo functional analyses done through gene knock - out and knock - in techniques in mice.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice