Sentences with phrase «functional genome analysis»

The 2006 Nobel Prize in Physiology or Medicine recognized the discovery RNA interference (RNAi), a basic mechanism of gene regulation that also provides an important new tool for functional genome analysis.

elegans system as the vehicle to deliver functional genome analysis into high school and college classes.

Not exact matches

Among other initiatives, his group contributes to ENCODE (Encyclopedia of DNA Elements), supported by NIH to define functional genomic elements; the DOE Systems Biology Knowledgebase (KBase) for data sharing and analysis; and the internationally funded 1000 Genomes Project on human genetic variation.

New DNA - based LASSO molecule probe can bind target genome regions for functional cloning and analysis.

«Some analyses of the ENCODE data alone have argued that upwards of 80 % of the genome is functional, but our evolutionary analysis suggests that isn't the case.»

This HDG genome represented the most complete de novo genome assembly to date, and with other omics data resources available from this individual, the work can be used as a benchmark for developing new sequencing and assembly techniques, and for functional studies involving RNA or protein analysis.

His development of a method for stable transformation of land plant chloroplast genomes, once thought to be impossible, established the field of chloroplast genome engineering in higher plants and has led to an explosion of research concerning the chloroplast genome's role in photosynthesis, functional analysis of plastid genes by reverse genetics, and mechanisms of plastid gene regulation.

The Cancer, Ageing and Somatic Mutation Programme encompasses three Projects that respectively cover the genomics of human cancers; functional analysis of the cancer genome using a range of in vitro and in vivo model systems; and the characterisation of somatic mutations in development and adult homeostasis in health and disease.

We expanded on our genome sequencing efforts to include efforts in whole genome gene expression analysis and functional analysis of genome variation.

We're looking for a postdoc to work on computational analysis of disease - associated and other functional variation in human genomes!

This indicates that a comprehensive and experimentally supported annotation effort of the human genome simultaneously highlights regions with striking differences in gene organization to other species and may indicate evolutionary events specific to the human lineage demanding further functional analyses.

In both cases, a combination of population genomics, genome mapping, and functional analyses identified recurrent and idiosyncratic genetic changes underlying the evolution of convergent phenotypes.

This work presents a genomic analysis of the UM270 gene functions as compared to other available pseudomonad genomes, highlighting the genetic and functional differences between each strain of this group of fluorescent and plant growth - promoting bacteria.

An extensive analysis of the whole - genome, including annotation of predicted genes and assignment of functional categories, analysis of chromosomal architecture and the distribution of transposable elements, and comparisons with other genomes, is presented with the publication of the sequences of chromosomes 1, 3, and 5.

Sur I, Tuupanen S, Whitington T, Aaltonen LA, Taipale J. Lessons from Functional Analysis of Genome - Wide Association Studies.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaAnalysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaanalysis of sequence variation.

He led the analysis group for the ENCODE project, which is defining functional elements in the human genome.

220/2: 30 PolyTest: A novel method for joint analysis of genome - wide association studies and functional annotations.

Already, comparative genomic analysis of six species of yeast has prompted scientists to significantly revise their initial catalog of yeast genes and to predict a new set of functional elements thought to play a role in regulating genome activity.

The Department of Microbiology of the Yonsei University College of Medicine, is investigating on identification and functional study of virulence determinants in Mycobacterium tuberculosis by comparative genome - based analysis.

Here we describe genome - engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regularly interspaced short palindromic repeats (CRISPR)- Cas9 platform for in situ high - content functional analysis of RREs.

Stanford University About Blog The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae along with search and analysis tools to explore these data, enabling the discovery of functional relationships between sequence and gene products in fungi and higher organisms.